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Biosym Technologies discover simulation software package
Discover Simulation Software Package, supplied by Biosym Technologies, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/software%2C+algorithm+neuron+simulation+environment/discover+software/pmc02373952-276-6-11
Average 90 stars, based on 1 article reviews
discover simulation software package - by Bioz Stars, 2026-10
90/100 stars

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Article Title: Initiation of Spectrin Dimerization Involves Complementary Electrostatic Interactions between Paired Triple-helical Bundles
Article Snippet: The Da14 model was then refined by constrained energy minimization with Discover® software (Biosym Technologies) using the all-atom constant valence force field.

Article Title: Structural characteristics of bullfrog (Rana catesbeiana) transthyretin and its cDNA--comparison of its pattern of expression during metamorphosis with that of lipocalin.
Article Snippet: Transthyretin, an extracellular thyroid-hormone-binding protein (THBP) in higher vertebrates, is synthesized and secreted by the choroid plexus of all classes of vertebrates, except fish and amphibians, and synthesized in the liver of endothermic animals.. Here, we report the nucleotide sequence of the cDNA for a THBP found in plasma of bullfrog (Rana catesbeiana) tadpoles before the climax of metamorphosis.. The amino acid sequence clearly shows this protein to be an amphibian transthyretin.

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Article Title: Stabilization of hen egg white lysozyme by a cavity-filling mutation
Article Snippet: CM-toyopearl 650M, a cation-exchange resin for the purification of secreted hen lysozymes, was obtained from Tosoh. .. Energy minimizations were performed using the Discover simulation software package from Biosym Technologies. ..

Article Title: Unimolecular micelles: Synthesis and characterization of amphiphilic polymer systems
Article Snippet: Unimolecular micelles were successfully synthesized from mucic acid, fatty acids, and poly(ethylene glycols) to create biocompatible polymers.. These polymers consist of a core-shell structure that resembles conventional micellar structures but with significant thermodynamic stability in aqueous media.. The core of the polymers provide a hydrophobic environment for drug encapsulation via hydrophobic interactions, whereas the shell provides excellent water solubility.

Article Title: Bijvoet in solution reveals unexpected stereoselectivity in a Michael addition.
Article Snippet: Although the determination of the relative configuration of stereocenters was first established by Fischer in 1891 through organic synthesis, the question of absolute configuration was not solved until the work of Bijvoet et al. in 1951 with anomalous X-ray diffraction.. For the majority of compounds that can neither be crystallized nor easily be converted into crystallizable derivatives, organic synthesis is still required to establish their stereochemistry.. Over the past two decades, the situation has been improved with the development of chiroptical techniques, such as optical rotation dispersion (ORD) and vibrational circular dichroism (VCD), that allow the configuration of all stereogenic elements to be determined in solution.

Article Title: Identification of the Binding Site for a Novel Class of CCR2b Chemokine Receptor Antagonists
Article Snippet: .. The final structure was minimized with a limited cycle using the Discover software (Biosym) and CVFF force field. ..

Article Title: Stabilization of hen egg white lysozyme by a cavity-filling mutation
Article Snippet: CM-toyopearl 650M, a cation-exchange resin for the purification of secreted hen lysozymes, was obtained from Tosoh. .. Energy minimization Energy minimizations were performed using the Discover simulation software package from Biosym Technologies. ..



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Neuromatic Devices software, algorithm neuron simulation environment
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