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dataset data type who grade ii who grade iii who grade iv cgga rna seq 291 334 388 rembrandt microarray  (Proteintech)


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    Proteintech dataset data type who grade ii who grade iii who grade iv cgga rna seq 291 334 388 rembrandt microarray
    FIGURE 3 Upregulation of IL4I1 infers an unfavorable prognosis for glioma. (A) Representative images (left) and quantification (right) showing IL4I1 staining of normal brain tissues (n = 16) and glioma tissues (n = 37) with the anti-IL4I1 antibody, with scale bars 100 µm (up) and 20 µm (down). (B–D) Kaplan– Meier analysis for OS based on three glioma datasets <t>(CGGA,</t> Rembrandt, and GSE16011). (E–G) ROC curves of OS in CGGA, Rembrandt, and GSE16011 datasets. (H, I) Univariate and multivariate analyses of OS based on CGGA-glioma datasets. ****p < 0.0001.
    Dataset Data Type Who Grade Ii Who Grade Iii Who Grade Iv Cgga Rna Seq 291 334 388 Rembrandt Microarray, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 398 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rna+microarray+data/SGCG+Antibody/pm38250074-89-0-30
    Average 96 stars, based on 398 article reviews
    dataset data type who grade ii who grade iii who grade iv cgga rna seq 291 334 388 rembrandt microarray - by Bioz Stars, 2026-09
    96/100 stars

    Images

    1) Product Images from "IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy."

    Article Title: IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.

    Journal: Frontiers in immunology

    doi: 10.3389/fimmu.2023.1338244

    FIGURE 3 Upregulation of IL4I1 infers an unfavorable prognosis for glioma. (A) Representative images (left) and quantification (right) showing IL4I1 staining of normal brain tissues (n = 16) and glioma tissues (n = 37) with the anti-IL4I1 antibody, with scale bars 100 µm (up) and 20 µm (down). (B–D) Kaplan– Meier analysis for OS based on three glioma datasets (CGGA, Rembrandt, and GSE16011). (E–G) ROC curves of OS in CGGA, Rembrandt, and GSE16011 datasets. (H, I) Univariate and multivariate analyses of OS based on CGGA-glioma datasets. ****p < 0.0001.
    Figure Legend Snippet: FIGURE 3 Upregulation of IL4I1 infers an unfavorable prognosis for glioma. (A) Representative images (left) and quantification (right) showing IL4I1 staining of normal brain tissues (n = 16) and glioma tissues (n = 37) with the anti-IL4I1 antibody, with scale bars 100 µm (up) and 20 µm (down). (B–D) Kaplan– Meier analysis for OS based on three glioma datasets (CGGA, Rembrandt, and GSE16011). (E–G) ROC curves of OS in CGGA, Rembrandt, and GSE16011 datasets. (H, I) Univariate and multivariate analyses of OS based on CGGA-glioma datasets. ****p < 0.0001.

    Techniques Used: Staining

    FIGURE 4 Heightened IL4I1 expression is correlated with the malignant phenotype of gliomas. (A–D) IL4I1 shows a significant increase in GBM (WHO IV) in TCGA, Rembrandt, GSE16011, and CGGA datasets. Additionally, box plots visualizing the associations between IL4I1 and various clinical characteristics based on the CGGA dataset. Specifically: (E) Age. (F) Status. (G) Histology. (H, I) High expression of IL4I1 in IDH wild-type and 1p/19q non-codel gliomas.
    Figure Legend Snippet: FIGURE 4 Heightened IL4I1 expression is correlated with the malignant phenotype of gliomas. (A–D) IL4I1 shows a significant increase in GBM (WHO IV) in TCGA, Rembrandt, GSE16011, and CGGA datasets. Additionally, box plots visualizing the associations between IL4I1 and various clinical characteristics based on the CGGA dataset. Specifically: (E) Age. (F) Status. (G) Histology. (H, I) High expression of IL4I1 in IDH wild-type and 1p/19q non-codel gliomas.

    Techniques Used: Expressing

    FIGURE 6 IL4I1 is expressed in M2-like macrophages in glioma. (A) Summary of IL4I1 expression in 12 distinct single-cell datasets from glioma patients. (B) Association between IL4I1 and macrophages on XCELL, TIMER, and EPIC algorithms. (C) Association between IL4I1 expression and markers of M1 and M2 macrophages in CGGA and TCGA databases. Color depth and digital scale represent the strength of association. (D) Representative colocalization images from IF staining between IL4I1 and CD206 in clinical glioma specimens. DAPI (blue), IL4I1 (red) and CD206 (green). Scale bar: 20 mm. (E) Measurement of protein and mRNA expression levels for markers (CD11B, CD204, CD86, CD206, and CD163) of THP-1, M0, M1, and M2 macrophages using WB and RT-qPCR. (F) Assessment of IL4I1 expression in various macrophage subtypes (M0, M1, and M2) and glioma cells (U87, LN229, and U251). (G) Representative IF pictures of the difference of IL4I1 among M0, M1, and M2 macrophages, U87, and LN229 cells with DAPI (blue) and IL4I1 (red). *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.
    Figure Legend Snippet: FIGURE 6 IL4I1 is expressed in M2-like macrophages in glioma. (A) Summary of IL4I1 expression in 12 distinct single-cell datasets from glioma patients. (B) Association between IL4I1 and macrophages on XCELL, TIMER, and EPIC algorithms. (C) Association between IL4I1 expression and markers of M1 and M2 macrophages in CGGA and TCGA databases. Color depth and digital scale represent the strength of association. (D) Representative colocalization images from IF staining between IL4I1 and CD206 in clinical glioma specimens. DAPI (blue), IL4I1 (red) and CD206 (green). Scale bar: 20 mm. (E) Measurement of protein and mRNA expression levels for markers (CD11B, CD204, CD86, CD206, and CD163) of THP-1, M0, M1, and M2 macrophages using WB and RT-qPCR. (F) Assessment of IL4I1 expression in various macrophage subtypes (M0, M1, and M2) and glioma cells (U87, LN229, and U251). (G) Representative IF pictures of the difference of IL4I1 among M0, M1, and M2 macrophages, U87, and LN229 cells with DAPI (blue) and IL4I1 (red). *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.

    Techniques Used: Expressing, Staining, Quantitative RT-PCR

    Related Articles

    Control:

    Article Title: Fibroblast-derived POSTN promotes colorectal cancer progression under high-fat diet by reprogramming fatty acid metabolism in tumor cell.
    Article Snippet: .. Use SREBP1 (1:1000 dilution, 290 AF6283, Affinity), CPT1A (1:1000 dilution, AF6558, Beyotime), ERK 291 (1:1000 dilution, GB11560, Servicebio), p-ERK (1:1000 dilution, 292 GB11004, Servicebio), AKT (1: 2000 dilution, AF1777, Beyotime) and 293 p-AKT (1:2000 dilution, AF1546, Beyotime), α-SMA (1:1000 dilution, 294 AF1032, Affinity), Collagen type I (1:2000 dilution, 14695-AP, 295 Proteintech), POSTN (1:10000 dilution,66491-1296 Ig,Proteintech),STAT3 (1:1000 dilution, 60199-1-Ig, Proteintech), p297 STAT3 (Ser727) (1:5000 dilution, 60479-1-Ig, Proteintech). β-actin 298 (1:2000 dilution, ZB15001-HRP-100, Servicebio) antibody was used 299 as control. .. Then, the PVDF membrane was incubated with the HRP300 conjugated secondary antibody (1:5000 dilution, BL003A/ BL001A, 301 Biosharp) for 1 hour, and the Western blot was developed using an 302 enhanced chemiluminescence kit.

    Incubation:

    Article Title: Establishment of a three-dimensional in vitro peri-implant bone-mucosa composite model
    Article Snippet: After rinsing, the samples were blocked with 2% bovine serum albumin (BSA, A9418, Sigma-Aldrich) in PBS for 30 min at 37 °C to prevent nonspecific binding. .. Scaffolds were further incubated with the Collagen Type I Polyclonal primary antibody (Col-I, 1:2000, 14695-1-AP, Proteintech) for 2 h at 37 °C or overnight at 4 °C. .. After washing four times with PBS, the samples were incubated for 1 h at room temperature or 30 min at 37 °C with the secondary antibody conjugated to DyLight ® 488 (Goat Anti-Rabbit IgG H&L, 1:200, ab96883, Abcam).

    Article Title: Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats
    Article Snippet: .. Primary antibodies against inducible nitric oxide synthase (iNOS; Affinity, USA; 1:2000), cyclooxygenase-2 (COX2; Huabio, China; 1:2000), type II collagen (Collagen II; Affinity, USA; 1:2000), aggrecan (Abclonal, USA; 1:1000), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5; Affinity, USA; 1:2000), matrix metalloproteinase 13 (MMP-13; Proteintech, USA; 1:1000), p16 (Abclonal, USA; 1:1000), p21 (Proteintech, USA; 1:2000), and p53 (Immunoway, USA; 1:2000) were incubated with the membrane overnight at 4 °C. .. After removing the primary antibody on ice, the membrane was washed three times with Tris-buffered saline containing Tween 20 (TBST) and then incubated with a horseradish peroxidase (HRP)-conjugated secondary antibody (Abclonal, USA) for 1 h at room temperature.

    Article Title: Establishment of a three-dimensional in vitro peri-implant bone-mucosa composite model.
    Article Snippet: After rinsing, the samples were blocked with 2% bovine serum albumin (BSA, A9418, Sigma-Aldrich) in PBS for 30 min at 37 °C to prevent nonspecific binding. .. Scaffolds were further incubated with the Collagen Type I Polyclonal primary antibody (Col-I, 1:2000, 14695-1-AP, Proteintech) for 2 h at 37 °C or overnight at 4 °C. .. After washing four times with PBS, the samples were incubated for 1 h at room temperature or 30 min at 37 °C with the secondary antibody conjugated to DyLight® 488 (Goat Anti-Rabbit IgG H&L, 1:200, ab96883, Abcam).

    Membrane:

    Article Title: Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats
    Article Snippet: .. Primary antibodies against inducible nitric oxide synthase (iNOS; Affinity, USA; 1:2000), cyclooxygenase-2 (COX2; Huabio, China; 1:2000), type II collagen (Collagen II; Affinity, USA; 1:2000), aggrecan (Abclonal, USA; 1:1000), a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5; Affinity, USA; 1:2000), matrix metalloproteinase 13 (MMP-13; Proteintech, USA; 1:1000), p16 (Abclonal, USA; 1:1000), p21 (Proteintech, USA; 1:2000), and p53 (Immunoway, USA; 1:2000) were incubated with the membrane overnight at 4 °C. .. After removing the primary antibody on ice, the membrane was washed three times with Tris-buffered saline containing Tween 20 (TBST) and then incubated with a horseradish peroxidase (HRP)-conjugated secondary antibody (Abclonal, USA) for 1 h at room temperature.

    Concentration Assay:

    Article Title: AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.
    Article Snippet: .. Antigen Immunogen description Source, host species, RRID Concentration DsRed DsRed-Express, a variant of Discosoma sp. red fluorescent protein Clontech, rabbit polyclonal Cat# 632496 Lot# 2103116 RRID: AB_10013483 1:2000 Forkhead box protein 2 (FoxP2) Recombinant human FoxP2 isoform 1 Ala640-Glu715 R&D Systems, sheep polyclonal Cat# AF5647 Lot# CCUB0221031 RRID: AB_2107133 1:3000 GFP Full-length green fluorescent protein from the jellyfish Aequorea victoria Invitrogen, chicken polyclonal, Cat# A10262 Lot# 2941309 RRID: AB_2534023 1:3000 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) Fusion protein Ag5146 (amino acids 1–405 encoded by human HSD11B2; GenBank BC036780) Protein Tech, rabbit polyclonal, Cat# 14192-1-AP Lot# 00087229 RRID: AB_2119643 1:2000 Lmx1b Full-length LIM homeobox transcription factor 1 beta protein from mouse C. Birchmeier, Max Delbruck Center for Molecular Medicine, Berlin; guinea pig polyclonal RRID: AB_2314752 1:8000 Tyrosine hydroxylase (TH) Native tyrosine hydroxylase from rat pheochromocytoma in sheep host Millipore, sheep polyclonal Cat# AB_1542 Lot# 4048632 RRID: AB_90755 1:2000 Tyrosine hydroxylase (TH) Tyrosine hydroxylase purified from PC12 cells Millipore, mouse polyclonal Cat# MAB_318 Lot# 3925547 RRID: AB_2201528 1:10,000 10969861, 2026, 1, D ow nloaded from https://onlinelibrary.w iley.com /doi/10.1002/cne.70125 by IN A SP - N E PA L , W iley O nline L ibrary on [02/01/2026]. .. See the T erm s and C onditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C transcardially with phosphate-buffered saline (PBS), followed by 10% formalin-PBS (SF100-20, Fischer Scientific).

    Variant Assay:

    Article Title: AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.
    Article Snippet: .. Antigen Immunogen description Source, host species, RRID Concentration DsRed DsRed-Express, a variant of Discosoma sp. red fluorescent protein Clontech, rabbit polyclonal Cat# 632496 Lot# 2103116 RRID: AB_10013483 1:2000 Forkhead box protein 2 (FoxP2) Recombinant human FoxP2 isoform 1 Ala640-Glu715 R&D Systems, sheep polyclonal Cat# AF5647 Lot# CCUB0221031 RRID: AB_2107133 1:3000 GFP Full-length green fluorescent protein from the jellyfish Aequorea victoria Invitrogen, chicken polyclonal, Cat# A10262 Lot# 2941309 RRID: AB_2534023 1:3000 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) Fusion protein Ag5146 (amino acids 1–405 encoded by human HSD11B2; GenBank BC036780) Protein Tech, rabbit polyclonal, Cat# 14192-1-AP Lot# 00087229 RRID: AB_2119643 1:2000 Lmx1b Full-length LIM homeobox transcription factor 1 beta protein from mouse C. Birchmeier, Max Delbruck Center for Molecular Medicine, Berlin; guinea pig polyclonal RRID: AB_2314752 1:8000 Tyrosine hydroxylase (TH) Native tyrosine hydroxylase from rat pheochromocytoma in sheep host Millipore, sheep polyclonal Cat# AB_1542 Lot# 4048632 RRID: AB_90755 1:2000 Tyrosine hydroxylase (TH) Tyrosine hydroxylase purified from PC12 cells Millipore, mouse polyclonal Cat# MAB_318 Lot# 3925547 RRID: AB_2201528 1:10,000 10969861, 2026, 1, D ow nloaded from https://onlinelibrary.w iley.com /doi/10.1002/cne.70125 by IN A SP - N E PA L , W iley O nline L ibrary on [02/01/2026]. .. See the T erm s and C onditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C transcardially with phosphate-buffered saline (PBS), followed by 10% formalin-PBS (SF100-20, Fischer Scientific).

    Recombinant:

    Article Title: AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.
    Article Snippet: .. Antigen Immunogen description Source, host species, RRID Concentration DsRed DsRed-Express, a variant of Discosoma sp. red fluorescent protein Clontech, rabbit polyclonal Cat# 632496 Lot# 2103116 RRID: AB_10013483 1:2000 Forkhead box protein 2 (FoxP2) Recombinant human FoxP2 isoform 1 Ala640-Glu715 R&D Systems, sheep polyclonal Cat# AF5647 Lot# CCUB0221031 RRID: AB_2107133 1:3000 GFP Full-length green fluorescent protein from the jellyfish Aequorea victoria Invitrogen, chicken polyclonal, Cat# A10262 Lot# 2941309 RRID: AB_2534023 1:3000 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) Fusion protein Ag5146 (amino acids 1–405 encoded by human HSD11B2; GenBank BC036780) Protein Tech, rabbit polyclonal, Cat# 14192-1-AP Lot# 00087229 RRID: AB_2119643 1:2000 Lmx1b Full-length LIM homeobox transcription factor 1 beta protein from mouse C. Birchmeier, Max Delbruck Center for Molecular Medicine, Berlin; guinea pig polyclonal RRID: AB_2314752 1:8000 Tyrosine hydroxylase (TH) Native tyrosine hydroxylase from rat pheochromocytoma in sheep host Millipore, sheep polyclonal Cat# AB_1542 Lot# 4048632 RRID: AB_90755 1:2000 Tyrosine hydroxylase (TH) Tyrosine hydroxylase purified from PC12 cells Millipore, mouse polyclonal Cat# MAB_318 Lot# 3925547 RRID: AB_2201528 1:10,000 10969861, 2026, 1, D ow nloaded from https://onlinelibrary.w iley.com /doi/10.1002/cne.70125 by IN A SP - N E PA L , W iley O nline L ibrary on [02/01/2026]. .. See the T erm s and C onditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C transcardially with phosphate-buffered saline (PBS), followed by 10% formalin-PBS (SF100-20, Fischer Scientific).

    Purification:

    Article Title: AAV-PHP.eB Peripheral Delivery and Central Expression in Cre Mice.
    Article Snippet: .. Antigen Immunogen description Source, host species, RRID Concentration DsRed DsRed-Express, a variant of Discosoma sp. red fluorescent protein Clontech, rabbit polyclonal Cat# 632496 Lot# 2103116 RRID: AB_10013483 1:2000 Forkhead box protein 2 (FoxP2) Recombinant human FoxP2 isoform 1 Ala640-Glu715 R&D Systems, sheep polyclonal Cat# AF5647 Lot# CCUB0221031 RRID: AB_2107133 1:3000 GFP Full-length green fluorescent protein from the jellyfish Aequorea victoria Invitrogen, chicken polyclonal, Cat# A10262 Lot# 2941309 RRID: AB_2534023 1:3000 11-beta-hydroxysteroid dehydrogenase type 2 (HSD2) Fusion protein Ag5146 (amino acids 1–405 encoded by human HSD11B2; GenBank BC036780) Protein Tech, rabbit polyclonal, Cat# 14192-1-AP Lot# 00087229 RRID: AB_2119643 1:2000 Lmx1b Full-length LIM homeobox transcription factor 1 beta protein from mouse C. Birchmeier, Max Delbruck Center for Molecular Medicine, Berlin; guinea pig polyclonal RRID: AB_2314752 1:8000 Tyrosine hydroxylase (TH) Native tyrosine hydroxylase from rat pheochromocytoma in sheep host Millipore, sheep polyclonal Cat# AB_1542 Lot# 4048632 RRID: AB_90755 1:2000 Tyrosine hydroxylase (TH) Tyrosine hydroxylase purified from PC12 cells Millipore, mouse polyclonal Cat# MAB_318 Lot# 3925547 RRID: AB_2201528 1:10,000 10969861, 2026, 1, D ow nloaded from https://onlinelibrary.w iley.com /doi/10.1002/cne.70125 by IN A SP - N E PA L , W iley O nline L ibrary on [02/01/2026]. .. See the T erm s and C onditions (https://onlinelibrary.w iley.com /term s-and-conditions) on W iley O nline L ibrary for rules of use; O A articles are governed by the applicable C reative C transcardially with phosphate-buffered saline (PBS), followed by 10% formalin-PBS (SF100-20, Fischer Scientific).



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    FIGURE 3 Upregulation of IL4I1 infers an unfavorable prognosis for glioma. (A) Representative images (left) and quantification (right) showing IL4I1 staining of normal brain tissues (n = 16) and glioma tissues (n = 37) with the anti-IL4I1 antibody, with scale bars 100 µm (up) and 20 µm (down). (B–D) Kaplan– Meier analysis for OS based on three glioma datasets <t>(CGGA,</t> Rembrandt, and GSE16011). (E–G) ROC curves of OS in CGGA, Rembrandt, and GSE16011 datasets. (H, I) Univariate and multivariate analyses of OS based on CGGA-glioma datasets. ****p < 0.0001.
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    Image Search Results


    Protein candidates proposed as potential prognostic markers for high and low risk of tumour recurrence in CRC-II patients.

    Journal: BJC Reports

    Article Title: Protein prognostic biomarkers in stage II colorectal cancer: implications for post-operative management

    doi: 10.1038/s44276-024-00043-z

    Figure Lengend Snippet: Protein candidates proposed as potential prognostic markers for high and low risk of tumour recurrence in CRC-II patients.

    Article Snippet: Candidate selection can be made via informatics approaches [ , ], DNA/RNA microarray data analyses [ ], protein involvement in key biochemical processes [ ], being differentially expressed through mass spectrometry (MS) analysis [ ], Olink proteomics assays [ ] or SomaLogic assays [ ] or as a diagnostic or prognostic marker for other tumour types [ ].

    Techniques: Biomarker Discovery, Expressing, Marker, Reverse Transcription Polymerase Chain Reaction, Microarray, Over Expression

    FIGURE 3 Upregulation of IL4I1 infers an unfavorable prognosis for glioma. (A) Representative images (left) and quantification (right) showing IL4I1 staining of normal brain tissues (n = 16) and glioma tissues (n = 37) with the anti-IL4I1 antibody, with scale bars 100 µm (up) and 20 µm (down). (B–D) Kaplan– Meier analysis for OS based on three glioma datasets (CGGA, Rembrandt, and GSE16011). (E–G) ROC curves of OS in CGGA, Rembrandt, and GSE16011 datasets. (H, I) Univariate and multivariate analyses of OS based on CGGA-glioma datasets. ****p < 0.0001.

    Journal: Frontiers in immunology

    Article Title: IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.

    doi: 10.3389/fimmu.2023.1338244

    Figure Lengend Snippet: FIGURE 3 Upregulation of IL4I1 infers an unfavorable prognosis for glioma. (A) Representative images (left) and quantification (right) showing IL4I1 staining of normal brain tissues (n = 16) and glioma tissues (n = 37) with the anti-IL4I1 antibody, with scale bars 100 µm (up) and 20 µm (down). (B–D) Kaplan– Meier analysis for OS based on three glioma datasets (CGGA, Rembrandt, and GSE16011). (E–G) ROC curves of OS in CGGA, Rembrandt, and GSE16011 datasets. (H, I) Univariate and multivariate analyses of OS based on CGGA-glioma datasets. ****p < 0.0001.

    Article Snippet: Dataset Data type WHO grade II WHO grade III WHO grade IV CGGA RNA-seq 291 334 388 Rembrandt Microarray 98 85 130 GSE16011 Microarray 24 85 159 frontiersin.org (1:2000, 60143-1-Ig, Proteintech), CD163 (1:1,000, ab182422, Abcam), CD86 (1:1,000, ab239075, Abcam), and beta-tubulin (1:2000, DF7967, Affinity) overnight.

    Techniques: Staining

    FIGURE 4 Heightened IL4I1 expression is correlated with the malignant phenotype of gliomas. (A–D) IL4I1 shows a significant increase in GBM (WHO IV) in TCGA, Rembrandt, GSE16011, and CGGA datasets. Additionally, box plots visualizing the associations between IL4I1 and various clinical characteristics based on the CGGA dataset. Specifically: (E) Age. (F) Status. (G) Histology. (H, I) High expression of IL4I1 in IDH wild-type and 1p/19q non-codel gliomas.

    Journal: Frontiers in immunology

    Article Title: IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.

    doi: 10.3389/fimmu.2023.1338244

    Figure Lengend Snippet: FIGURE 4 Heightened IL4I1 expression is correlated with the malignant phenotype of gliomas. (A–D) IL4I1 shows a significant increase in GBM (WHO IV) in TCGA, Rembrandt, GSE16011, and CGGA datasets. Additionally, box plots visualizing the associations between IL4I1 and various clinical characteristics based on the CGGA dataset. Specifically: (E) Age. (F) Status. (G) Histology. (H, I) High expression of IL4I1 in IDH wild-type and 1p/19q non-codel gliomas.

    Article Snippet: Dataset Data type WHO grade II WHO grade III WHO grade IV CGGA RNA-seq 291 334 388 Rembrandt Microarray 98 85 130 GSE16011 Microarray 24 85 159 frontiersin.org (1:2000, 60143-1-Ig, Proteintech), CD163 (1:1,000, ab182422, Abcam), CD86 (1:1,000, ab239075, Abcam), and beta-tubulin (1:2000, DF7967, Affinity) overnight.

    Techniques: Expressing

    FIGURE 6 IL4I1 is expressed in M2-like macrophages in glioma. (A) Summary of IL4I1 expression in 12 distinct single-cell datasets from glioma patients. (B) Association between IL4I1 and macrophages on XCELL, TIMER, and EPIC algorithms. (C) Association between IL4I1 expression and markers of M1 and M2 macrophages in CGGA and TCGA databases. Color depth and digital scale represent the strength of association. (D) Representative colocalization images from IF staining between IL4I1 and CD206 in clinical glioma specimens. DAPI (blue), IL4I1 (red) and CD206 (green). Scale bar: 20 mm. (E) Measurement of protein and mRNA expression levels for markers (CD11B, CD204, CD86, CD206, and CD163) of THP-1, M0, M1, and M2 macrophages using WB and RT-qPCR. (F) Assessment of IL4I1 expression in various macrophage subtypes (M0, M1, and M2) and glioma cells (U87, LN229, and U251). (G) Representative IF pictures of the difference of IL4I1 among M0, M1, and M2 macrophages, U87, and LN229 cells with DAPI (blue) and IL4I1 (red). *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.

    Journal: Frontiers in immunology

    Article Title: IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy.

    doi: 10.3389/fimmu.2023.1338244

    Figure Lengend Snippet: FIGURE 6 IL4I1 is expressed in M2-like macrophages in glioma. (A) Summary of IL4I1 expression in 12 distinct single-cell datasets from glioma patients. (B) Association between IL4I1 and macrophages on XCELL, TIMER, and EPIC algorithms. (C) Association between IL4I1 expression and markers of M1 and M2 macrophages in CGGA and TCGA databases. Color depth and digital scale represent the strength of association. (D) Representative colocalization images from IF staining between IL4I1 and CD206 in clinical glioma specimens. DAPI (blue), IL4I1 (red) and CD206 (green). Scale bar: 20 mm. (E) Measurement of protein and mRNA expression levels for markers (CD11B, CD204, CD86, CD206, and CD163) of THP-1, M0, M1, and M2 macrophages using WB and RT-qPCR. (F) Assessment of IL4I1 expression in various macrophage subtypes (M0, M1, and M2) and glioma cells (U87, LN229, and U251). (G) Representative IF pictures of the difference of IL4I1 among M0, M1, and M2 macrophages, U87, and LN229 cells with DAPI (blue) and IL4I1 (red). *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.

    Article Snippet: Dataset Data type WHO grade II WHO grade III WHO grade IV CGGA RNA-seq 291 334 388 Rembrandt Microarray 98 85 130 GSE16011 Microarray 24 85 159 frontiersin.org (1:2000, 60143-1-Ig, Proteintech), CD163 (1:1,000, ab182422, Abcam), CD86 (1:1,000, ab239075, Abcam), and beta-tubulin (1:2000, DF7967, Affinity) overnight.

    Techniques: Expressing, Staining, Quantitative RT-PCR