spocd1 human tagged open reading frame (OriGene)
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OriGene
spocd1 human tagged open reading frame
Spocd1 Human Tagged Open Reading Frame, supplied by OriGene, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/origin+reference+frame+function/pmc11880929-64-34-48?v=OriGene
Average 93 stars, based on 2 article reviews
Spocd1 Human Tagged Open Reading Frame, supplied by OriGene, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/origin+reference+frame+function/pmc11880929-64-34-48?v=OriGene
Average 93 stars, based on 2 article reviews
spocd1 human tagged open reading frame - by Bioz Stars,
2026-08
93/100 stars
Images
1) Product Images from "SPOCD1 Enhances Cancer Cell Activities and Serves as a Prognosticator in Esophageal Squamous Cell Carcinoma"
Article Title: SPOCD1 Enhances Cancer Cell Activities and Serves as a Prognosticator in Esophageal Squamous Cell Carcinoma
Journal: Cancer Genomics & Proteomics
doi: 10.21873/cgp.20503
Figure Legend Snippet: SPOCD1 mRNA expression and the effects of siRNA-mediated SPOCD1 knockdown in ESCC cells. (A) SPOCD1 mRNA levels in 20 ESCC cell lines. (B) Heatmap from CCLE data illustrating expression of genes highly correlated with SPOCD1 and their related pathways in 25 ESCC lines (C) siRNA-mediated knockdown effect of SPOCD1 in KYSE590 and KYSE70 cells on SPOCD1 expression. (D) Simple Western images illustrating detection of SPOCD1 and siRNA-mediated knockdown efficiency of SPOCD1 in KYSE590 and KYSE70 cells. Error bars indicate the standard deviation. *p<0.05, **p<0.01, ***p<0.001.
Techniques Used: Expressing, Knockdown, Simple Western, Standard Deviation
Figure Legend Snippet: Effects of siRNA-mediated SPOCD1 knockdown on ESCC cell function in vitro. (A) Proliferation of KYSE590 and KYSE70 cells in which SPOCD1 expression was inhibited using an SPOCD1-specific siRNA. (B) Migration wound healing assay in which SPOCD1 expression was inhibited in KYSE590 cells treated with an SPOCD1-specific siRNA. The left panel shows representative images of invasion, and the right panel shows the mean length of migration. (C) Cell invasion assay of KYSE70 cells in which SPOCD1 expression was inhibited by an SPOCD-siRNA. The left panels show representative images of stained invading KYSE70 cells (×200 magnification). The right graph shows the mean numbers of invaded cells in eight randomly selected fields. (D) Efficiency of enforced expression of SPOCD1 in KYSE1440 compared with that in cells transduced with the control vector. (E) Analysis of cell proliferation in KYSE1440 cells transduced with a control vector and si-SPOCD1. Error bars indicate the standard deviation. *p<0.05, **p<0.01, ***p<0.001. Asterisk refers to the comparison of si-SPOCD1 group to both untransfected and si-control groups in plots A and B.
Techniques Used: Knockdown, Cell Function Assay, In Vitro, Expressing, Migration, Wound Healing Assay, Invasion Assay, Staining, Transduction, Control, Plasmid Preparation, Standard Deviation, Comparison
Figure Legend Snippet: Effect of SPOCD1 knockdown on subcutaneous tumor formation in mouse xenograft models of KYSE70 cells. (A) Estimated sizes (mm) of tumors among untransfected, si-Control, and si-SPOCD1 groups (B). Images of all tumor nodules collected from the mice. (C) Average tumor weight comparison among groups. Error bars indicate the standard deviation. *p<0.05, **p<0.01, ***p<0.001. Asterisk refers to the comparison of si-SPOCD1 group to both untransfected and si-control groups in plots A.
Techniques Used: Knockdown, Control, Comparison, Standard Deviation
Figure Legend Snippet: Expression of SPOCD1 mRNA in ESCC tissue and its prognostic value. (A) qRT-PCR analysis of SPOCD1 mRNA expression in ESCC tissues and paired normal esophageal mucosa tissues from 164 patients. (B) Kaplan–Meyer analysis of disease-specific survival of 164 patients who underwent radical resection for ESCC. (C) External validation of overall survival data from TGCA. (D) Kaplan–Meyer analysis of disease-specific survival of 164 patients who underwent radical resection for ESCC. (E) Frequencies of the sites of initial recurrence after radical esophagectomy. Error bars indicate standard deviation. *p<0.05, **p<0.01, ***p<0.001, ns: Not significant.
Techniques Used: Expressing, Quantitative RT-PCR, Biomarker Discovery, Standard Deviation
Figure Legend Snippet: Association between expression level of SPOCD1 mRNA and clinicopathological parameters in 164 patients with esophageal squamous cell carcinoma.
Techniques Used: Expressing
Figure Legend Snippet: Analysis of SPOCD1 expression in ESCC tissues and its prognostic value. (A) Representative images of immunohistochemical detection in a TMA. Examples of negative (0) and positive (1+, 2+, and 3+) expression levels are shown (200× and 1,000× magnification). (B) Kaplan–Meyer analysis of disease-specific and disease-free survival of 177 patients stages I-III ESCC who underwent radical resection of the esophagus.
Techniques Used: Expressing, Immunohistochemical staining