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Novus Biologicals tissue microarrays

Expression of SORT1 in ovarian healthy and tumoral tissues. Immunohistochemical staining of SORT1 in tissue <t>microarrays</t> (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in ovarian tumors. With the immunohistochemical (IHC) scoring system used, the level of expressed SORT1 ranged from 0 to a maximum of 12. ( A ) Representative SORT1 staining by IHC in ovarian healthy, primary and metastases biopsies. Nuclei are stained blue with hematoxylin. Arrows point to ovarian healthy epithelia. Black bars represent 50 µm. ( B ) IHC scores from healthy tissues ( n = 20), benign tumors ( n = 18), malignant tumors ( n = 45) and metastases ( n = 10). ( C ) RT-qPCR was used to quantify the transcript levels of SORT1 in healthy and cancerous ovarian tissues. The SORT1 transcript levels in tumor samples were segregated according to tumor grade and then compared to the values from healthy ovarian tissues. n = 8 for healthy and for Grade I tumor samples, n = 9 for Grade II, n = 17 for Grade III and n = 7 for Grade IV tumor samples. ( D ) The mean IHC scores for SORT1 is shown for healthy ovarian tissue ( n = 20), benign tumors ( n = 18), LGSC ( n = 21), HGSC ( n = 6), CCC ( n = 5), MC ( n = 3), EC ( n = 13), TCC ( n = 5) and GC and NE ( n = 20). All scatter plots include lines showing the means ± SEM, and where each point represents an individual tissue sample.

Tissue Microarrays, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 93/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/normal+human+tissue+microarray/pmc09031804-76-1-19?v=Novus+Biologicals
Average 93 stars, based on 4 article reviews

tissue microarrays - by Bioz Stars, 2026-08

93/100 stars

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1) Product Images from "The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers"

Article Title: The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers

Journal: Cancers

doi: 10.3390/cancers14081877

Expression of SORT1 in ovarian healthy and tumoral tissues. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in ovarian tumors. With the immunohistochemical (IHC) scoring system used, the level of expressed SORT1 ranged from 0 to a maximum of 12. ( A ) Representative SORT1 staining by IHC in ovarian healthy, primary and metastases biopsies. Nuclei are stained blue with hematoxylin. Arrows point to ovarian healthy epithelia. Black bars represent 50 µm. ( B ) IHC scores from healthy tissues ( n = 20), benign tumors ( n = 18), malignant tumors ( n = 45) and metastases ( n = 10). ( C ) RT-qPCR was used to quantify the transcript levels of SORT1 in healthy and cancerous ovarian tissues. The SORT1 transcript levels in tumor samples were segregated according to tumor grade and then compared to the values from healthy ovarian tissues. n = 8 for healthy and for Grade I tumor samples, n = 9 for Grade II, n = 17 for Grade III and n = 7 for Grade IV tumor samples. ( D ) The mean IHC scores for SORT1 is shown for healthy ovarian tissue ( n = 20), benign tumors ( n = 18), LGSC ( n = 21), HGSC ( n = 6), CCC ( n = 5), MC ( n = 3), EC ( n = 13), TCC ( n = 5) and GC and NE ( n = 20). All scatter plots include lines showing the means ± SEM, and where each point represents an individual tissue sample.

Figure Legend Snippet: Expression of SORT1 in ovarian healthy and tumoral tissues. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in ovarian tumors. With the immunohistochemical (IHC) scoring system used, the level of expressed SORT1 ranged from 0 to a maximum of 12. ( A ) Representative SORT1 staining by IHC in ovarian healthy, primary and metastases biopsies. Nuclei are stained blue with hematoxylin. Arrows point to ovarian healthy epithelia. Black bars represent 50 µm. ( B ) IHC scores from healthy tissues ( n = 20), benign tumors ( n = 18), malignant tumors ( n = 45) and metastases ( n = 10). ( C ) RT-qPCR was used to quantify the transcript levels of SORT1 in healthy and cancerous ovarian tissues. The SORT1 transcript levels in tumor samples were segregated according to tumor grade and then compared to the values from healthy ovarian tissues. n = 8 for healthy and for Grade I tumor samples, n = 9 for Grade II, n = 17 for Grade III and n = 7 for Grade IV tumor samples. ( D ) The mean IHC scores for SORT1 is shown for healthy ovarian tissue ( n = 20), benign tumors ( n = 18), LGSC ( n = 21), HGSC ( n = 6), CCC ( n = 5), MC ( n = 3), EC ( n = 13), TCC ( n = 5) and GC and NE ( n = 20). All scatter plots include lines showing the means ± SEM, and where each point represents an individual tissue sample.

Techniques Used: Expressing, Immunohistochemical staining, Staining, Quantitative RT-PCR

Expression of SORT1 in endometrial healthy tissues and endometrial tumor biopsies. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in endometrial tumors. ( A ) Representative SORT1 staining by IHC in endometrial healthy tissue and endometrial tumor biopsies. Nuclei are stained blue with hematoxylin. Black bars represent 50 µm. ( B ) SORT1 IHC scores between healthy endometrial tissues ( n = 2) and endometrial cancerous tissues ( n = 12). Scatter plot include lines showing the means ± SEM, and where each point represents an individual tissue sample.

Figure Legend Snippet: Expression of SORT1 in endometrial healthy tissues and endometrial tumor biopsies. Immunohistochemical staining of SORT1 in tissue microarrays (TMAs) was used to measure the level of SORT1 expression in healthy tissues and in endometrial tumors. ( A ) Representative SORT1 staining by IHC in endometrial healthy tissue and endometrial tumor biopsies. Nuclei are stained blue with hematoxylin. Black bars represent 50 µm. ( B ) SORT1 IHC scores between healthy endometrial tissues ( n = 2) and endometrial cancerous tissues ( n = 12). Scatter plot include lines showing the means ± SEM, and where each point represents an individual tissue sample.

Techniques Used: Expressing, Immunohistochemical staining, Staining

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tissue microarrays (Novus Biologicals)

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1) Product Images from "The Peptide-Drug Conjugate TH1902: A New Sortilin Receptor-Mediated Cancer Therapeutic against Ovarian and Endometrial Cancers"

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