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arm targeting cancer biomarker her2  (Rockland Immunochemicals)


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    Structured Review

    Rockland Immunochemicals arm targeting cancer biomarker her2
    NCI SBIR–Funded TRT Contracts for 2015
    Arm Targeting Cancer Biomarker Her2, supplied by Rockland Immunochemicals, used in various techniques. Bioz Stars score: 90/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/node/Recombinant+Anti-HER2+Fab+antibody/pmc06910624-10-31-2
    Average 90 stars, based on 3 article reviews
    arm targeting cancer biomarker her2 - by Bioz Stars, 2026-11
    90/100 stars

    Images

    1) Product Images from "Advancing Targeted Radionuclide Therapy Through the National Cancer Institute’s Small Business Innovation Research Pathway"

    Article Title: Advancing Targeted Radionuclide Therapy Through the National Cancer Institute’s Small Business Innovation Research Pathway

    Journal: Journal of Nuclear Medicine

    doi: 10.2967/jnumed.118.214684

    NCI SBIR–Funded TRT Contracts for 2015
    Figure Legend Snippet: NCI SBIR–Funded TRT Contracts for 2015

    Techniques Used: In Vitro, In Vivo, Marker, Fluorescence, Drug discovery, Imaging

    NCI SBIR–Funded TRT Contracts from 2016 to 2017
    Figure Legend Snippet: NCI SBIR–Funded TRT Contracts from 2016 to 2017

    Techniques Used: Radioactivity, Drug discovery, Recombinant, Biomarker Discovery, In Vivo, Fluorescence, Binding Assay, Labeling, In Vitro, Produced, Software

    Related Articles

    Incubation:

    Article Title: Methods and compositions using peptides and proteins with C-terminal elements
    Article Snippet: .. For the standard curve, microtiter wells coated with 5 μg/ml rabbit anti-human IgG (SouthernBiotech) were incubated with a mixture of various concentrations of Herceptin (ranging from 0.01 to 10 μg/ml) and 1 μg/ml at final concentration of biotinylated human IgG (Rockland Immunochemicals, Gilbertsville, Pa.). ..

    Article Title: Methods and compositions using peptides and proteins with c-terminal elements
    Article Snippet: .. For the standard curve, microtiter wells coated with 5 μg/ml rabbit anti-human IgG (SouthernBiotech) were incubated with a mixture of various concentrations of Herceptin (ranging from 0.01 to 10 μg/ml) and 1 μg/ml at final concentration of biotinylated human IgG (Rockland Immunochemicals, Gilbertsville, PA). ..

    Article Title: Methods and compositions using peptides and proteins with C-terminal elements
    Article Snippet: .. For the standard curve, microtiter wells coated with 5 μg/ml rabbit anti-human IgG (SouthernBiotech) were incubated with a mixture of various concentrations of Herceptin (ranging from 0.01 to 10 μg/ml) and 1 μg/ml at final concentration of biotinylated human IgG (Rockland Immunochemicals, Gilbertsville, Pa.). ..

    Concentration Assay:

    Article Title: Methods and compositions using peptides and proteins with C-terminal elements
    Article Snippet: .. For the standard curve, microtiter wells coated with 5 μg/ml rabbit anti-human IgG (SouthernBiotech) were incubated with a mixture of various concentrations of Herceptin (ranging from 0.01 to 10 μg/ml) and 1 μg/ml at final concentration of biotinylated human IgG (Rockland Immunochemicals, Gilbertsville, Pa.). ..

    Article Title: Methods and compositions using peptides and proteins with c-terminal elements
    Article Snippet: .. For the standard curve, microtiter wells coated with 5 μg/ml rabbit anti-human IgG (SouthernBiotech) were incubated with a mixture of various concentrations of Herceptin (ranging from 0.01 to 10 μg/ml) and 1 μg/ml at final concentration of biotinylated human IgG (Rockland Immunochemicals, Gilbertsville, PA). ..

    Article Title: Methods and compositions using peptides and proteins with C-terminal elements
    Article Snippet: .. For the standard curve, microtiter wells coated with 5 μg/ml rabbit anti-human IgG (SouthernBiotech) were incubated with a mixture of various concentrations of Herceptin (ranging from 0.01 to 10 μg/ml) and 1 μg/ml at final concentration of biotinylated human IgG (Rockland Immunochemicals, Gilbertsville, Pa.). ..

    Recombinant:

    Article Title: Advancing Targeted Radionuclide Therapy Through the National Cancer Institute’s Small Business Innovation Research Pathway
    Article Snippet: 2016 , RadImmune, Inc. , Phase I , Metastatic melanoma , , Melanin , Conjugate 8C3 IgG with chelating agents to enable radiolabeling with α- and β-emitting therapeutic radionuclides; assess pharmacokinetics/pharmacodynamics and radiation dosimetry of radiolabeled 8C3 in murine and human melanoma models; perform proof-of-concept radioimmunotherapy experiments to assess efficacy and short-term toxicity. .. 2016 , Rockland Immunochemicals, Inc. , Phase I , HER2-positive cancers , 68 Ga and 177 Lu , HER2 and digoxigenin , Phase I: Develop bispecific recombinant single-domain antibodies with one arm targeting cancer biomarker HER2 and another arm against digoxigenin; investigate in vivo clearance, tumor accumulation, stability, and ability to capture digoxigenylated fluorescence dyes and radionuclides. .. 2016 , Houston Pharmaceuticals, Inc. , Phase I , Pancreatic cancer , , IL-13RA2 receptor , Develop radiolabeled ligand that selectively binds IL-13RA2 receptor; determine its stability and binding characteristics; determine pharmacokinetics and biodistribution of radioligand in clinically relevant model of PDAC.

    Biomarker Discovery:

    Article Title: Advancing Targeted Radionuclide Therapy Through the National Cancer Institute’s Small Business Innovation Research Pathway
    Article Snippet: 2016 , RadImmune, Inc. , Phase I , Metastatic melanoma , , Melanin , Conjugate 8C3 IgG with chelating agents to enable radiolabeling with α- and β-emitting therapeutic radionuclides; assess pharmacokinetics/pharmacodynamics and radiation dosimetry of radiolabeled 8C3 in murine and human melanoma models; perform proof-of-concept radioimmunotherapy experiments to assess efficacy and short-term toxicity. .. 2016 , Rockland Immunochemicals, Inc. , Phase I , HER2-positive cancers , 68 Ga and 177 Lu , HER2 and digoxigenin , Phase I: Develop bispecific recombinant single-domain antibodies with one arm targeting cancer biomarker HER2 and another arm against digoxigenin; investigate in vivo clearance, tumor accumulation, stability, and ability to capture digoxigenylated fluorescence dyes and radionuclides. .. 2016 , Houston Pharmaceuticals, Inc. , Phase I , Pancreatic cancer , , IL-13RA2 receptor , Develop radiolabeled ligand that selectively binds IL-13RA2 receptor; determine its stability and binding characteristics; determine pharmacokinetics and biodistribution of radioligand in clinically relevant model of PDAC.

    In Vivo:

    Article Title: Advancing Targeted Radionuclide Therapy Through the National Cancer Institute’s Small Business Innovation Research Pathway
    Article Snippet: 2016 , RadImmune, Inc. , Phase I , Metastatic melanoma , , Melanin , Conjugate 8C3 IgG with chelating agents to enable radiolabeling with α- and β-emitting therapeutic radionuclides; assess pharmacokinetics/pharmacodynamics and radiation dosimetry of radiolabeled 8C3 in murine and human melanoma models; perform proof-of-concept radioimmunotherapy experiments to assess efficacy and short-term toxicity. .. 2016 , Rockland Immunochemicals, Inc. , Phase I , HER2-positive cancers , 68 Ga and 177 Lu , HER2 and digoxigenin , Phase I: Develop bispecific recombinant single-domain antibodies with one arm targeting cancer biomarker HER2 and another arm against digoxigenin; investigate in vivo clearance, tumor accumulation, stability, and ability to capture digoxigenylated fluorescence dyes and radionuclides. .. 2016 , Houston Pharmaceuticals, Inc. , Phase I , Pancreatic cancer , , IL-13RA2 receptor , Develop radiolabeled ligand that selectively binds IL-13RA2 receptor; determine its stability and binding characteristics; determine pharmacokinetics and biodistribution of radioligand in clinically relevant model of PDAC.

    Stability:

    Article Title: Advancing Targeted Radionuclide Therapy Through the National Cancer Institute’s Small Business Innovation Research Pathway
    Article Snippet: 2016 , RadImmune, Inc. , Phase I , Metastatic melanoma , , Melanin , Conjugate 8C3 IgG with chelating agents to enable radiolabeling with α- and β-emitting therapeutic radionuclides; assess pharmacokinetics/pharmacodynamics and radiation dosimetry of radiolabeled 8C3 in murine and human melanoma models; perform proof-of-concept radioimmunotherapy experiments to assess efficacy and short-term toxicity. .. 2016 , Rockland Immunochemicals, Inc. , Phase I , HER2-positive cancers , 68 Ga and 177 Lu , HER2 and digoxigenin , Phase I: Develop bispecific recombinant single-domain antibodies with one arm targeting cancer biomarker HER2 and another arm against digoxigenin; investigate in vivo clearance, tumor accumulation, stability, and ability to capture digoxigenylated fluorescence dyes and radionuclides. .. 2016 , Houston Pharmaceuticals, Inc. , Phase I , Pancreatic cancer , , IL-13RA2 receptor , Develop radiolabeled ligand that selectively binds IL-13RA2 receptor; determine its stability and binding characteristics; determine pharmacokinetics and biodistribution of radioligand in clinically relevant model of PDAC.

    Fluorescence:

    Article Title: Advancing Targeted Radionuclide Therapy Through the National Cancer Institute’s Small Business Innovation Research Pathway
    Article Snippet: 2016 , RadImmune, Inc. , Phase I , Metastatic melanoma , , Melanin , Conjugate 8C3 IgG with chelating agents to enable radiolabeling with α- and β-emitting therapeutic radionuclides; assess pharmacokinetics/pharmacodynamics and radiation dosimetry of radiolabeled 8C3 in murine and human melanoma models; perform proof-of-concept radioimmunotherapy experiments to assess efficacy and short-term toxicity. .. 2016 , Rockland Immunochemicals, Inc. , Phase I , HER2-positive cancers , 68 Ga and 177 Lu , HER2 and digoxigenin , Phase I: Develop bispecific recombinant single-domain antibodies with one arm targeting cancer biomarker HER2 and another arm against digoxigenin; investigate in vivo clearance, tumor accumulation, stability, and ability to capture digoxigenylated fluorescence dyes and radionuclides. .. 2016 , Houston Pharmaceuticals, Inc. , Phase I , Pancreatic cancer , , IL-13RA2 receptor , Develop radiolabeled ligand that selectively binds IL-13RA2 receptor; determine its stability and binding characteristics; determine pharmacokinetics and biodistribution of radioligand in clinically relevant model of PDAC.

    Affinity Purification:

    Article Title: Label free gravimetric detection of epidermal growth factor receptor by antibody immobilization on quartz crystal microbalance
    Article Snippet: An efficient and simple method for the detection of epidermal growth factor receptor (EGFR) using anti-EGFR immobilized quartz crystal microbalance (QCM) was developed.. The immobilization of antiEGFR on the gold surface of QCM electrode was constructed by a self-assembled monolayer (SAM) of thiosalicylic acid followed by the activation of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS).. In order to assess the sensitivity of QCM, two analytical procedures namely, dip-and-dry and flow cell methods were investigated.



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