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Novus Biologicals human tissue microarray
Human Tissue Microarray, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 90/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/nbp2-42042/Human+Normal+Tissue+MicroArray+(Normal)/pm12871983-52-10-14
Average 90 stars, based on 5 article reviews

human tissue microarray - by Bioz Stars, 2026-10

90/100 stars

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Microarray:

Article Title: Characterization of matriptase expression in normal human tissues.
Article Snippet: Tissue Specimens Normal human tissues were obtained as a normal human tissue microarray from Imgenex (San Diego, CA) and as whole tissue sections from the Histopathology and Tissue Shared Resource at the Lombardi Cancer Center, Georgetown University. .. The Imgenex tissue microarray contains 59 cores of normal human tissues representing all of the major human organ systems. ..

Article Title: Characterization of matriptase expression in normal human tissues.
Article Snippet: .. Tissue Specimens Normal human tissues were obtained as a normal human tissue microarray from Imgenex (San Diego, CA) and as whole tissue sections from the Histopathology and Tissue Shared Resource at the Lombardi Cancer Center, Georgetown University. .. The Imgenex tissue microarray contains 59 cores of normal human tissues representing all of the major human organ systems.

Article Title: Prostate Field Cancerization: Deregulated Expression of Macrophage Inhibitory Cytokine 1 (MIC-1) and Platelet Derived Growth Factor A (PDGF-A) in Tumor Adjacent Tissue
Article Snippet: .. A human prostate tissue microarray featuring 9 histologically normal tissues matched to their corresponding tumors was purchased from Novus Biologicals (catalog #NBP2–30169; San Diego CA). ..

Histopathology:

other:

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs
Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Article Title: Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule
Article Snippet: U20S cells engineered to express PD-1 and CTLA-4 were obtained from DiscoveRx (Fremont, USA) and cultured using media provided by the manufacturer.

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Adult Human Normal Tissue Lysates and Monkey Normal Tissue Cell Lysates

Journal: Journal of Inflammation Research

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

doi: 10.2147/JIR.S357866

Figure Lengend Snippet: Adult Human Normal Tissue Lysates and Monkey Normal Tissue Cell Lysates

Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Techniques:

Adult Human and Monkey Normal PBMCs Lysates

Journal: Journal of Inflammation Research

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

doi: 10.2147/JIR.S357866

Figure Lengend Snippet: Adult Human and Monkey Normal PBMCs Lysates

Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Techniques:

TILRR protein expression in normal human tissues. Tissue lysates (2.5 µg/lane protein) were examined by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph (see Figure S1A for un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad) and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph (see Figure S1B for un-cropped blot image). The bar graph shows the TILRR protein intensity (R.F.U) for each tissue lysate (n=1) where X-axis demonstrates the normal human tissue lysates and Y-axis indicates the signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units; S. intestine, small intestine (ileum).

Journal: Journal of Inflammation Research

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

doi: 10.2147/JIR.S357866

Figure Lengend Snippet: TILRR protein expression in normal human tissues. Tissue lysates (2.5 µg/lane protein) were examined by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph (see Figure S1A for un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad) and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph (see Figure S1B for un-cropped blot image). The bar graph shows the TILRR protein intensity (R.F.U) for each tissue lysate (n=1) where X-axis demonstrates the normal human tissue lysates and Y-axis indicates the signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units; S. intestine, small intestine (ileum).

Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Techniques: Expressing, Western Blot, Staining, Fluorescence

TILRR protein expression in normal Cynomolgus monkey tissues. ( A ) Tissue lysates (5.0 µg/lane proteins) were examined by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph ( Figure S1C shows the un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad) and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph ( Figure S1D shows the un-cropped gel). The bar graph indicates the TILRR protein intensity (R.F.U) for each tissue lysate (n=1). ( B ) TILRR protein intensity (R.F.U) (median with interquartile range [IQR]) of each tissue cell lysate observed in two cynomolgus monkeys (n=2). The X-axis represents the normal Cynomolgus monkey tissue cell lysates and Y-axis shows the signal intensity (R.F.U). AM271 and BM843 are the monkeys’ identification numbers. kDa, kiloDalton; RFU, relative fluorescence units; n= number of subjects.

Journal: Journal of Inflammation Research

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

doi: 10.2147/JIR.S357866

Figure Lengend Snippet: TILRR protein expression in normal Cynomolgus monkey tissues. ( A ) Tissue lysates (5.0 µg/lane proteins) were examined by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph ( Figure S1C shows the un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad) and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph ( Figure S1D shows the un-cropped gel). The bar graph indicates the TILRR protein intensity (R.F.U) for each tissue lysate (n=1). ( B ) TILRR protein intensity (R.F.U) (median with interquartile range [IQR]) of each tissue cell lysate observed in two cynomolgus monkeys (n=2). The X-axis represents the normal Cynomolgus monkey tissue cell lysates and Y-axis shows the signal intensity (R.F.U). AM271 and BM843 are the monkeys’ identification numbers. kDa, kiloDalton; RFU, relative fluorescence units; n= number of subjects.

Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Techniques: Expressing, Western Blot, Staining, Fluorescence

TILRR protein expression in normal human and macaque PBMCs. ( A ) PBMC lysates (14.0 µg/lane proteins) of humans (n=4), rhesus monkeys (n=4), and cynomolgus monkeys (n=4) were analyzed by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph (see Figure S2A for un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad), and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph (see Figure S2B for un-cropped gel). The bar graph shows the TILRR protein intensity (R.F.U). ( B ) TILRR protein intensity (R.F.U) (median with IQR) of PBMC lysates observed in four study subjects (n=4) including humans, rhesus monkeys, and cynomolgus monkeys. ( C ) TILRR protein expression between humans and monkeys. Data are shown as median with IQR in figures B and C . A t -test with 95% CI was used for statistical comparisons and all p<0.05 were reported as statistically significant and presented with asterisks. The X-axis of figure A indicates the patients’ and monkeys’ identification numbers and Y-axis shows the signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units; n= number of subjects; ID#, identification number, Rhesus M, rhesus monkey; Cyno M, cynomolgus monkey.

Journal: Journal of Inflammation Research

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

doi: 10.2147/JIR.S357866

Figure Lengend Snippet: TILRR protein expression in normal human and macaque PBMCs. ( A ) PBMC lysates (14.0 µg/lane proteins) of humans (n=4), rhesus monkeys (n=4), and cynomolgus monkeys (n=4) were analyzed by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph (see Figure S2A for un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad), and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph (see Figure S2B for un-cropped gel). The bar graph shows the TILRR protein intensity (R.F.U). ( B ) TILRR protein intensity (R.F.U) (median with IQR) of PBMC lysates observed in four study subjects (n=4) including humans, rhesus monkeys, and cynomolgus monkeys. ( C ) TILRR protein expression between humans and monkeys. Data are shown as median with IQR in figures B and C . A t -test with 95% CI was used for statistical comparisons and all p<0.05 were reported as statistically significant and presented with asterisks. The X-axis of figure A indicates the patients’ and monkeys’ identification numbers and Y-axis shows the signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units; n= number of subjects; ID#, identification number, Rhesus M, rhesus monkey; Cyno M, cynomolgus monkey.

Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Techniques: Expressing, Western Blot, Staining, Fluorescence

TILRR protein expression in human cell lines. Cell line lysates (7 µg/lane protein) were examined by Western blot (green color, left) and Coomassie blue (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph ( Figure S3A shows the un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad) and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph ( Figure S3B shows the un-cropped gel). The bar graph shows the TILRR protein intensity (R.F.U) for each tissue lysate (n=1) where X-axis demonstrates human cell lines and Y-axis represents signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units.

Journal: Journal of Inflammation Research

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

doi: 10.2147/JIR.S357866

Figure Lengend Snippet: TILRR protein expression in human cell lines. Cell line lysates (7 µg/lane protein) were examined by Western blot (green color, left) and Coomassie blue (red color, right). TILRR protein was probed by primary mouse anti-TILRR F218G4 mAb followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph ( Figure S3A shows the un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad) and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph ( Figure S3B shows the un-cropped gel). The bar graph shows the TILRR protein intensity (R.F.U) for each tissue lysate (n=1) where X-axis demonstrates human cell lines and Y-axis represents signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units.

Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Techniques: Expressing, Western Blot, Staining, Fluorescence

Anti-TILRR mAb is specific for TILRR protein. Tissues lysates (2.5 µg/lane protein) (n=2) were examined by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by either primary mouse anti-TILRR F218G4 mAb or primary mouse IgG1 mAb (isotype control) (Abcam, Canada) followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph (see Figure S4A for un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad), and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph (see Figure S4B for un-cropped gel). The bar graph shows the TILRR protein intensity (R.F.U) for each tissue lysate where X-axis represents human tissue lysates and Y-axis indicates the signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units.

Journal: Journal of Inflammation Research

Article Title: Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs

doi: 10.2147/JIR.S357866

Figure Lengend Snippet: Anti-TILRR mAb is specific for TILRR protein. Tissues lysates (2.5 µg/lane protein) (n=2) were examined by Western blot (green color, left) and Coomassie blue staining (red color, right). TILRR protein was probed by either primary mouse anti-TILRR F218G4 mAb or primary mouse IgG1 mAb (isotype control) (Abcam, Canada) followed by secondary goat anti-mouse IRDye 800CW antibody (1:10,000; LI-COR). TILRR protein bands (70 kDa, green color, cropped) are shown on the top of the bar graph (see Figure S4A for un-cropped blot image). Untransferred proteins in the gel after iBlot transfer were stained with Coomassie blue staining (G-250, Bio-Rad), and the protein bands (~70 kDa, red color, cropped) are shown on the top of the bar graph (see Figure S4B for un-cropped gel). The bar graph shows the TILRR protein intensity (R.F.U) for each tissue lysate where X-axis represents human tissue lysates and Y-axis indicates the signal intensity (R.F.U). kDa, kiloDalton; RFU, relative fluorescence units.

Article Snippet: Human Normal Tissue Lysates (Supplier: Novus Biologicals, Bio-Techne Canada) , , , , , , , , .

Techniques: Western Blot, Staining, Control, Fluorescence

Cells Co-expressing PD-1 and CTLA-4 Are More Prevalent in the Tumor Microenvironment (A) In situ RNA hybridization of PD-1 and CTLA-4 probes in ovarian cancer tumor cores (N = 21) analyzed using RNAscope and quantified with HALO software. Each square represents an individual core, with red and blue circles representing the indicated frequency of PD-1 and CTLA-4 expression, respectively. The first square shows PD-1 and CTLA-4 expression in a non-malignant ovary sample. (B) In situ RNA hybridization of PD-1 (red) and CTLA-4 (blue) probes visualized by RNAscope in representative tumor microarray core or healthy tonsil samples. (C) Fraction of cells co-expressing PD-1 and CTLA-4 RNA detected by ISH in lymphoid organs from healthy donors (N = 7) or tumor samples from randomly selected patients (N = 12). Means and standard deviations (SDs) are shown. (D) Peripheral blood mononuclear cells (PBMCs) from healthy donors (N = 8) and PBMCs (N = 27) or dissociated tumor cells (DTCs) (N = 7) from patients with various cancers were stained for PD-1 and CTLA-4 expression and analyzed by flow cytometry. Box and whiskers plots depict the minimum, first quartile, median, third quartile, and maximum. Gated on viable CD45 + /CD3 + cells. (E) Representative fluorescence-activated cell sorting (FACS) images from (D) gated on viable T cells. See also <xref ref-type=

Figure S1 . " width="100%" height="100%">

Journal: Cell Reports Medicine

Article Title: Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule

doi: 10.1016/j.xcrm.2020.100163

Figure Lengend Snippet: Cells Co-expressing PD-1 and CTLA-4 Are More Prevalent in the Tumor Microenvironment (A) In situ RNA hybridization of PD-1 and CTLA-4 probes in ovarian cancer tumor cores (N = 21) analyzed using RNAscope and quantified with HALO software. Each square represents an individual core, with red and blue circles representing the indicated frequency of PD-1 and CTLA-4 expression, respectively. The first square shows PD-1 and CTLA-4 expression in a non-malignant ovary sample. (B) In situ RNA hybridization of PD-1 (red) and CTLA-4 (blue) probes visualized by RNAscope in representative tumor microarray core or healthy tonsil samples. (C) Fraction of cells co-expressing PD-1 and CTLA-4 RNA detected by ISH in lymphoid organs from healthy donors (N = 7) or tumor samples from randomly selected patients (N = 12). Means and standard deviations (SDs) are shown. (D) Peripheral blood mononuclear cells (PBMCs) from healthy donors (N = 8) and PBMCs (N = 27) or dissociated tumor cells (DTCs) (N = 7) from patients with various cancers were stained for PD-1 and CTLA-4 expression and analyzed by flow cytometry. Box and whiskers plots depict the minimum, first quartile, median, third quartile, and maximum. Gated on viable CD45 + /CD3 + cells. (E) Representative fluorescence-activated cell sorting (FACS) images from (D) gated on viable T cells. See also Figure S1 .

Article Snippet: Normal human tissue microarray and tumor microarrays of ovarian, breast, lung, colon, rectal cancer samples were provided by Advanced Cell Diagnostic (Newark, USA).

Techniques: Expressing, In Situ, Hybridization, RNAscope, Software, Microarray, Staining, Flow Cytometry, Fluorescence, FACS

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