Microarray:Article Title: Pharmacogenomics
Article Snippet: .. Open in a separate window INCYTE Figure Incyte's microarray service allows researchers to analyse differential expression in normal and diseased cells Protein Phenotype Drugs Modified response Enzymes Plasma pseudocholinesterase Slow hydrolysis of certain esters Succinylcholine Prolonged apnoea N-acetyltransferase Slow, rapid acetylators Isoniazid Slow: toxic neuritis, lupus erythematosus Procainamide Disease susceptibility Dapsone Slow: bladder cancer Sulfadimidine, sulfasalazine, p-aminosalicylic acid, heterocyclic amines (food mutagens) Rapid: colorectal cancer Thiopurine methyltransferase Poor thiopurine methyltransferase methylators 6-mercaptopurine, 6-thioguanine, azathioprin Bone marow toxicity, liver damage Dihydropyrimidine dehydrogenase Slow inactivation 5-fluorouracil Possible enhanced toxicity Aldehyde dehydrogenase Fast, slow metabolisers Ethanol Slow: facial flushing Fast: protected from liver cirrhosis Catechol O-methyl transferase High, low methylators Levodopa, methyldopa Low: increased response Cytochrome P-450 subtype CYP 2D6 Ultrarapid * Debrisoquine Poor: increased toxicity Sparteine Extensive * Phenformin Extensive: lung cancer? ..
Article Title: Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains.
Article Snippet: Reduced replicative capacity is a consistent characteristic of cells derived from patients with Werner syndrome.. This premature senescence is phenotypically similar to replicative senescence observed in normal cell strains and includes altered cell morphology and gene expression patterns.. Telomeres shorten with in vitro passaging of both WRN and normal cell strains; however, the rate of shortening has been reported to be faster in WRN cell strains, and the length of telomeres in senescent WRN cells appears to be longer than that observed in normal strains, leading to the suggestion that senescence in WRN cell strains may not be exclusively associated with telomere effects.
Article Title: Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis.
Article Snippet: Transgenic mice with cardiac-specific over-expression of tumor necrosis factor-a (TNF1.6) progress to dilated heart failure.. A significant inflammatory response precedes functional deterioration, and may contribute to cardiac damage in this model. To evaluate the underlying molecular mechanisms, we assessed the gene expression in six groups of mouse hearts defined by age, gender, and phenotype (n = 3/group) using Affymetrix microarray analysis.. Phenotype was defined as compensated (in young TNF1.6) or decompensated (in older TNF1.6) via echocardiogram.
Quantitative Proteomics:Article Title: Pharmacogenomics
Article Snippet: .. Open in a separate window INCYTE Figure Incyte's microarray service allows researchers to analyse differential expression in normal and diseased cells Protein Phenotype Drugs Modified response Enzymes Plasma pseudocholinesterase Slow hydrolysis of certain esters Succinylcholine Prolonged apnoea N-acetyltransferase Slow, rapid acetylators Isoniazid Slow: toxic neuritis, lupus erythematosus Procainamide Disease susceptibility Dapsone Slow: bladder cancer Sulfadimidine, sulfasalazine, p-aminosalicylic acid, heterocyclic amines (food mutagens) Rapid: colorectal cancer Thiopurine methyltransferase Poor thiopurine methyltransferase methylators 6-mercaptopurine, 6-thioguanine, azathioprin Bone marow toxicity, liver damage Dihydropyrimidine dehydrogenase Slow inactivation 5-fluorouracil Possible enhanced toxicity Aldehyde dehydrogenase Fast, slow metabolisers Ethanol Slow: facial flushing Fast: protected from liver cirrhosis Catechol O-methyl transferase High, low methylators Levodopa, methyldopa Low: increased response Cytochrome P-450 subtype CYP 2D6 Ultrarapid * Debrisoquine Poor: increased toxicity Sparteine Extensive * Phenformin Extensive: lung cancer? ..
Modification:Article Title: Pharmacogenomics
Article Snippet: .. Open in a separate window INCYTE Figure Incyte's microarray service allows researchers to analyse differential expression in normal and diseased cells Protein Phenotype Drugs Modified response Enzymes Plasma pseudocholinesterase Slow hydrolysis of certain esters Succinylcholine Prolonged apnoea N-acetyltransferase Slow, rapid acetylators Isoniazid Slow: toxic neuritis, lupus erythematosus Procainamide Disease susceptibility Dapsone Slow: bladder cancer Sulfadimidine, sulfasalazine, p-aminosalicylic acid, heterocyclic amines (food mutagens) Rapid: colorectal cancer Thiopurine methyltransferase Poor thiopurine methyltransferase methylators 6-mercaptopurine, 6-thioguanine, azathioprin Bone marow toxicity, liver damage Dihydropyrimidine dehydrogenase Slow inactivation 5-fluorouracil Possible enhanced toxicity Aldehyde dehydrogenase Fast, slow metabolisers Ethanol Slow: facial flushing Fast: protected from liver cirrhosis Catechol O-methyl transferase High, low methylators Levodopa, methyldopa Low: increased response Cytochrome P-450 subtype CYP 2D6 Ultrarapid * Debrisoquine Poor: increased toxicity Sparteine Extensive * Phenformin Extensive: lung cancer? ..
Clinical Proteomics:Article Title: Pharmacogenomics
Article Snippet: .. Open in a separate window INCYTE Figure Incyte's microarray service allows researchers to analyse differential expression in normal and diseased cells Protein Phenotype Drugs Modified response Enzymes Plasma pseudocholinesterase Slow hydrolysis of certain esters Succinylcholine Prolonged apnoea N-acetyltransferase Slow, rapid acetylators Isoniazid Slow: toxic neuritis, lupus erythematosus Procainamide Disease susceptibility Dapsone Slow: bladder cancer Sulfadimidine, sulfasalazine, p-aminosalicylic acid, heterocyclic amines (food mutagens) Rapid: colorectal cancer Thiopurine methyltransferase Poor thiopurine methyltransferase methylators 6-mercaptopurine, 6-thioguanine, azathioprin Bone marow toxicity, liver damage Dihydropyrimidine dehydrogenase Slow inactivation 5-fluorouracil Possible enhanced toxicity Aldehyde dehydrogenase Fast, slow metabolisers Ethanol Slow: facial flushing Fast: protected from liver cirrhosis Catechol O-methyl transferase High, low methylators Levodopa, methyldopa Low: increased response Cytochrome P-450 subtype CYP 2D6 Ultrarapid * Debrisoquine Poor: increased toxicity Sparteine Extensive * Phenformin Extensive: lung cancer? ..
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