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Structured Review

Rosetta Inpharmatics microarray profiles
A previously published <t>microarray</t> data set from the fresh-frozen tissue bank of the Netherlands Cancer Institute for a panel of 295 breast cancer sample was analyzed. The resulting Kaplan-Meier kinetic analyses of survival data revealed that high levels of EphA2 mRNA expression correlated with a decrease in overall survival (A, p=0.009) and recurrence-free survival (B, p=0.009).
Microarray Profiles, supplied by Rosetta Inpharmatics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/microarray+profile/microarray+profiles/pmc03859619-41-8-22
Average 90 stars, based on 1 article reviews
microarray profiles - by Bioz Stars, 2026-10
90/100 stars

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1) Product Images from "Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy"

Article Title: Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy

Journal: Cancer research

doi: 10.1158/0008-5472.CAN-09-1845

A previously published microarray data set from the fresh-frozen tissue bank of the Netherlands Cancer Institute for a panel of 295 breast cancer sample was analyzed. The resulting Kaplan-Meier kinetic analyses of survival data revealed that high levels of EphA2 mRNA expression correlated with a decrease in overall survival (A, p=0.009) and recurrence-free survival (B, p=0.009).
Figure Legend Snippet: A previously published microarray data set from the fresh-frozen tissue bank of the Netherlands Cancer Institute for a panel of 295 breast cancer sample was analyzed. The resulting Kaplan-Meier kinetic analyses of survival data revealed that high levels of EphA2 mRNA expression correlated with a decrease in overall survival (A, p=0.009) and recurrence-free survival (B, p=0.009).

Techniques Used: Microarray, Expressing

Related Articles

Microarray:

Article Title: Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy
Article Snippet: .. Survival analysis The van der Vijver database, with microarray profiles of 295 human breast tumors and associated clinical data, was obtained from Rosetta Inpharmatics ( http://www.rii.com/publications/2002/nejm.html ). ..

Article Title: Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231
Article Snippet: .. SPCA1 expression was assessed in breast cancer clinical samples and cell lines in a dataset obtained from Rosetta Inpharmatics consisting of the microarray profiles of 295 primary breast tumors ( 33 ) and an Affymetrix microarray dataset of breast cancer cell lines classified as basal-like or luminal as described previously ( 34 , 35 ). .. For Affymetrix data, the probe 209935_at was assessed.

Article Title: Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231
Article Snippet: .. Microarray Analysis—SPCA1 expression was assessed in breast cancer clinical samples and cell lines in a dataset obtained from Rosetta Inpharmatics consisting of the microarray profiles of 295 primary breast tumors (33) and an Affymetrix microarray dataset of breast cancer cell lines classified as basallike or luminal as described previously (34, 35). .. For Affymetrix data, the probe 209935_at was assessed.

Article Title: ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer
Article Snippet: The entry of calcium into the mammary epithelial cell from the maternal plasma (i.e., calcium influx mechanisms) during lactation is poorly understood.. As alterations in calcium channels and pumps are a key feature of some cancers, including breast cancer, understanding these calcium influx pathways may have significance beyond mammary biology.. We show that the store-operated calcium influx protein, Orai1, is increased during lactation whereas the Orai1 activator Stim1, but not Stim2, is downregulated.

Article Title: Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin ?5?1 and Fibronectin
Article Snippet: Proteins labeled on the cell surface were detected with streptavidin-horseradish peroxidase (HRP) conjugate (GE Healthcare) at a 1:500 dilution. .. Survival analysis A gene expression data set including the microarray profiles of 295 human breast cancers and the associated clinical data ( 12 ) was obtained from Rosetta Inpharmatics. ..

Article Title: Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
Article Snippet: .. SPCA2 Analysis in Human Breast Tumors A gene expression dataset consisting of the microarray profiles of 295 primary human breast tumors ( van de Vijver et al., 2002 ) was obtained from Rosetta Inpharmatics (Seattle, WA). ..

Article Title: Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
Article Snippet: .. A gene expression dataset consisting of the microarray profiles of 295 primary human breast tumors ( van de Vijver et al., 2002 ) was obtained from Rosetta Inpharmatics (Seattle, WA). ..

Article Title: Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
Article Snippet: .. Microarray data from Chin et al. and van de Vijver et al. , were downloaded from the Lawrence Berkeley National Laboratory ( http://cancer.lbl.gov/breastcancer/list_data.php?id=9 ) and Rosetta Inpharmatics ( http://www.rii.com/publications/2002/nejm.html ), respectively. ..

Expressing:

Article Title: Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231
Article Snippet: .. SPCA1 expression was assessed in breast cancer clinical samples and cell lines in a dataset obtained from Rosetta Inpharmatics consisting of the microarray profiles of 295 primary breast tumors ( 33 ) and an Affymetrix microarray dataset of breast cancer cell lines classified as basal-like or luminal as described previously ( 34 , 35 ). .. For Affymetrix data, the probe 209935_at was assessed.

Article Title: Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231
Article Snippet: .. Microarray Analysis—SPCA1 expression was assessed in breast cancer clinical samples and cell lines in a dataset obtained from Rosetta Inpharmatics consisting of the microarray profiles of 295 primary breast tumors (33) and an Affymetrix microarray dataset of breast cancer cell lines classified as basallike or luminal as described previously (34, 35). .. For Affymetrix data, the probe 209935_at was assessed.

Gene Expression:

Article Title: ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer
Article Snippet: The entry of calcium into the mammary epithelial cell from the maternal plasma (i.e., calcium influx mechanisms) during lactation is poorly understood.. As alterations in calcium channels and pumps are a key feature of some cancers, including breast cancer, understanding these calcium influx pathways may have significance beyond mammary biology.. We show that the store-operated calcium influx protein, Orai1, is increased during lactation whereas the Orai1 activator Stim1, but not Stim2, is downregulated.

Article Title: Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin ?5?1 and Fibronectin
Article Snippet: Proteins labeled on the cell surface were detected with streptavidin-horseradish peroxidase (HRP) conjugate (GE Healthcare) at a 1:500 dilution. .. Survival analysis A gene expression data set including the microarray profiles of 295 human breast cancers and the associated clinical data ( 12 ) was obtained from Rosetta Inpharmatics. ..

Article Title: Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
Article Snippet: .. SPCA2 Analysis in Human Breast Tumors A gene expression dataset consisting of the microarray profiles of 295 primary human breast tumors ( van de Vijver et al., 2002 ) was obtained from Rosetta Inpharmatics (Seattle, WA). ..

Article Title: Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors
Article Snippet: .. A gene expression dataset consisting of the microarray profiles of 295 primary human breast tumors ( van de Vijver et al., 2002 ) was obtained from Rosetta Inpharmatics (Seattle, WA). ..



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