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locally estimated scatterplot smoothing regression  (RStudio)

 
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    RStudio locally estimated scatterplot smoothing regression
    Pharmacokinetic curves of moxifloxacin with and without rifampicin coadministration of in‐house collected therapeutic drug monitoring (TDM) data for 400 mg of moxifloxacin only (A), 400 mg moxifloxacin with any dose of rifampicin (B), and 600 mg of moxifloxacin with any dose of rifampicin (C); median rifampicin dose for both group B and C was 1200 mg once daily (range, 450‐2000 mg). The x‐axis indicates time after last dose. Open circles and crosses indicate measured individual data from in‐house TDM data of patients with Mycobacterium tuberculosis or nontuberculous mycobacteria infections, respectively; the solid black lines indicate the fitted plasma concentration‐time curve using locally estimated <t>scatterplot</t> smoothing regression; and the gray area represents the 95% confidence interval around the regression. AUC 0‐24 , area under the plasma concentration–time curve from time 0 to 24 hours; C max , maximum plasma concentration.
    Locally Estimated Scatterplot Smoothing Regression, supplied by RStudio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/locally+estimated+scatterplot+smoothing+(loess)/locally+estimated+scatterplot+smoothing+regression/pmc09297990-46-17-21
    Average 90 stars, based on 1 article reviews
    locally estimated scatterplot smoothing regression - by Bioz Stars, 2026-11
    90/100 stars

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    1) Product Images from "Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling"

    Article Title: Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling

    Journal: Journal of Clinical Pharmacology

    doi: 10.1002/jcph.1972

    Pharmacokinetic curves of moxifloxacin with and without rifampicin coadministration of in‐house collected therapeutic drug monitoring (TDM) data for 400 mg of moxifloxacin only (A), 400 mg moxifloxacin with any dose of rifampicin (B), and 600 mg of moxifloxacin with any dose of rifampicin (C); median rifampicin dose for both group B and C was 1200 mg once daily (range, 450‐2000 mg). The x‐axis indicates time after last dose. Open circles and crosses indicate measured individual data from in‐house TDM data of patients with Mycobacterium tuberculosis or nontuberculous mycobacteria infections, respectively; the solid black lines indicate the fitted plasma concentration‐time curve using locally estimated scatterplot smoothing regression; and the gray area represents the 95% confidence interval around the regression. AUC 0‐24 , area under the plasma concentration–time curve from time 0 to 24 hours; C max , maximum plasma concentration.
    Figure Legend Snippet: Pharmacokinetic curves of moxifloxacin with and without rifampicin coadministration of in‐house collected therapeutic drug monitoring (TDM) data for 400 mg of moxifloxacin only (A), 400 mg moxifloxacin with any dose of rifampicin (B), and 600 mg of moxifloxacin with any dose of rifampicin (C); median rifampicin dose for both group B and C was 1200 mg once daily (range, 450‐2000 mg). The x‐axis indicates time after last dose. Open circles and crosses indicate measured individual data from in‐house TDM data of patients with Mycobacterium tuberculosis or nontuberculous mycobacteria infections, respectively; the solid black lines indicate the fitted plasma concentration‐time curve using locally estimated scatterplot smoothing regression; and the gray area represents the 95% confidence interval around the regression. AUC 0‐24 , area under the plasma concentration–time curve from time 0 to 24 hours; C max , maximum plasma concentration.

    Techniques Used: Clinical Proteomics, Concentration Assay

    Related Articles

    Clinical Proteomics:

    Article Title: Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling
    Article Snippet: .. Individual plasma concentrations were plotted against time and a plasma concentration‐time curve was fitted using locally estimated scatterplot smoothing regression in R Studio version 1.1.463 (RStudio, Inc, Boston, Massachusetts) after which a C max was determined. ..

    Article Title: Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling.
    Article Snippet: .. Individual plasma concentrations were plotted against time and a plasma concentration-time curve was fitted using locally estimated scatterplot smoothing regression in R Studio version 1.1.463 (RStudio, Inc, Boston, Massachusetts) after which a Cmax was determined. ..

    Concentration Assay:

    Article Title: Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling
    Article Snippet: .. Individual plasma concentrations were plotted against time and a plasma concentration‐time curve was fitted using locally estimated scatterplot smoothing regression in R Studio version 1.1.463 (RStudio, Inc, Boston, Massachusetts) after which a C max was determined. ..

    Article Title: Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling.
    Article Snippet: .. Individual plasma concentrations were plotted against time and a plasma concentration-time curve was fitted using locally estimated scatterplot smoothing regression in R Studio version 1.1.463 (RStudio, Inc, Boston, Massachusetts) after which a Cmax was determined. ..



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