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genetic algorithm with local search options (ga-ls)  (AUTODOCK GmbH)

 
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    AUTODOCK GmbH genetic algorithm with local search options (ga-ls)
    Genetic Algorithm With Local Search Options (Ga Ls), supplied by AUTODOCK GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/genetic+algorithm+function+ga/genetic+algorithm+with+local+search+option++ga+ls+/pmc03121799-128-5-11
    Average 90 stars, based on 1 article reviews
    genetic algorithm with local search options (ga-ls) - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Influence of human serum albumin on longitudinal and transverse relaxation rates (r1 and r2) of magnetic resonance contrast agents.
    Article Snippet: Objectives: Exogenous magnetic resonance (MR) contrast media (CM) are used to improve detection and delineation of physiological and pathologic structures.. Temporary binding between CM and proteins such as human serum albumin (HSA) may alter the relaxation-enhancing properties of specific contrast agents.. In this study, the presence and strength of HSA interaction with different CM was investigated.

    Article Title: HIV-1 capsid assembly inhibitor (CAI) peptide: structural preferences and delivery into human embryonic lung cells and lymphocytes.
    Article Snippet: The genetic algorithm with local search option (GA-LS) as implemented in AutoDock was used to dock the flexible peptide.

    Article Title: Synthesis, antitumor activity and molecular docking study of novel sulfonamide-Schiff's bases, thiazolidinones, benzothiazinones and their C-nucleoside derivatives.
    Article Snippet: A series of sulfapyridine-polyhydroxyalkylidene (or arylidene)-imino derivatives (Schiff’s bases) 2a–c and 4a–e were prepared by condensation of 4-amino-N-pyridin-2-ylbenzenesulfonamide (1) with different monosaccharides or with aromatic aldehydes.. Treatment of 2a–c with thioglycolic acid led to the formation of the C-nucleosides (3a–c), while treatment of 4a–e with thioglycolic and/or thiosalicylic acids afforded the corresponding 2-arylthiazolidin-4-one or 2-arylbenzothiazin-4-one derivatives 5a–e and/or 6a–e, respectively.. Some representative examples of the newly prepared compounds showed considerable cytotoxic effect against breast carcinoma cell line MCF7 and cervix carcinoma cell line HELA in comparison with 5-flurouracil and doxorubicin.

    Article Title: Identification and characterization of riproximin, a new type II ribosome-inactivating protein with antineoplastic activity from Ximenia americana.
    Article Snippet: The aim of this study was to identify and characterize the active component(s) of Ximenia americana plant material used to treat cancer in African traditional medicine.. By a combination of preextraction, extraction, ion exchange and affinity chromatography, a mixture of two cytotoxic proteins was isolated.. Using degenerated primers designed on the de novo sequence of two tryptic peptides from one of these proteins, a DNA fragment was amplified and the sequence obtained was used to determine the complete cDNA sequence by the RACE method.

    Article Title: Mechanism of Heparin Acceleration of Tissue Inhibitor of Metalloproteases-1 (TIMP-1) Degradation by the Human Neutrophil Elastase
    Article Snippet: The genetic algorithm with local search options (GA-LS) as implemented in AutoDock was used to dock the flexible heparin fragments, with 4500 search runs using an initial population of 200 conformations.



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