dapi (Cell Signaling Technology Inc)
Cell Signaling Technology Inc is a verified supplier 
Cell Signaling Technology Inc manufactures this product 
98
Structured Review
Cell Signaling Technology Inc
dapi
Dapi, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 2159 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dapi+d9542/DAPI/pmc09143354-75-0-30
Average 98 stars, based on 2159 article reviews
Dapi, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 2159 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dapi+d9542/DAPI/pmc09143354-75-0-30
Average 98 stars, based on 2159 article reviews
dapi - by Bioz Stars,
2026-10
98/100 stars
Images
1) Product Images from "Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma"
Article Title: Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma
Journal: Pharmaceuticals
doi: 10.3390/ph15050636
Figure Legend Snippet: Utt-B triggers apoptotic mode of cell death in HCC, exhibiting better therapeutic efficacy compared to sorafenib ( A ) MTT assay of sorafenib in the indicated liver cancer cell lines. ( B ) Assessment of sorafenib cytotoxicity in HepG2 cells, as assessed by MTT Assay. ( C ) A plot between Utt-B vs. sorafenib treatment, in vitro, # p ≤ 0.001, significant. ( D ) Cytotoxicity analysis of sorafenib in normal hepatocytes, Chang Liver. ( E ) DAPI staining indicating that Utt-B induces more nuclear condensation in HepG2 cells, than sorafenib. ( F ) Clonogenic assay reveals an augmented anti-clonogenic potential of Utt-B than that of sorafenib. One-way ANOVA was used for statistical analysis, * p ≤ 0.1; ** p ≤ 0.01. ( G ) Annexin-PI flow cytometric analysis shows an increase in apoptosis of HCC cells upon Utt-B treatment. Two-way ANOVA was performed for statistical analysis. ( H ) Wound healing assay showing the augmented anti-migratory potential of Utt-B than that of sorafenib. ( I – K ) Immunoblot analysis demonstrates an enhancement in cleavage of caspase 9, 7, and PARP in HepG2 cells treated with Utt-B, in comparison to sorafenib. Statistical analysis was done using One-way ANOVA, **** p ≤ 0.0001. ( L ) A scheme depicting the induction of human HCC tumors in NOD-SCID mice using HepG2 cells. ( M ) An image of xenograft-excised tumors post-drug treatment regimen. ( N ) A graphical representation of tumor volumes of indicated treatment groups. Two-way ANOVA was used for statistical analysis, *** p ≤ 0.001, ** p ≤ 0.01.
Techniques Used: Drug discovery, MTT Assay, In Vitro, Staining, Clonogenic Assay, Wound Healing Assay, Western Blot, Comparison
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