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ERITHACUS SOFTWARE LIMITED computer program grafit 4.0.12
Computer Program Grafit 4.0.12, supplied by ERITHACUS SOFTWARE LIMITED, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computer+program+grafit/computer+program+grafit+4+0+12/pm12969744-53-3-5
Average 90 stars, based on 1 article reviews
computer program grafit 4.0.12 - by Bioz Stars, 2026-11
90/100 stars

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Article Title: Pharmacology of GABA(A) receptors exhibiting different levels of spontaneous activity.
Article Snippet: The present study examines the spontaneous channel activity of GABAA receptors and the pharmacology of various full agonists (gaminobutyric acid (GABA), isoguvacine), partial agonists (4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol (THIP), piperidine-4-sulphonic acid (P4S), imidazole-4-acetic acid), competitive antagonists (bicuculline, 2-(3-carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide (SR95531)) and non-competitive antagonists (picrotoxinin, zinc).. Experiments were performed on oocytes separately expressing human a1h2g2S, a1h3q and a1h2(L259S)g2S receptors using two-electrode voltage clamp electrophysiology.. Quantifying spontaneous channel activity showed this varied significantly between the a1h2g2S (0.2F 0.07%), a1h3q (20F 3%) and a1h2(L259S)g2S (83F 4%) receptors.



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