multiplecomputer automated structure evaluation (multicase) (MultiCASE Inc)
90
Structured Review
MultiCASE Inc
multiplecomputer automated structure evaluation (multicase)
Multiplecomputer Automated Structure Evaluation (Multicase), supplied by MultiCASE Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computational+optimization+software/optimized++computer+automated+structure+evaluation++mcase++software+program/pm12924582-63-27-31
Average 90 stars, based on 1 article reviews
Multiplecomputer Automated Structure Evaluation (Multicase), supplied by MultiCASE Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/computational+optimization+software/optimized++computer+automated+structure+evaluation++mcase++software+program/pm12924582-63-27-31
Average 90 stars, based on 1 article reviews
multiplecomputer automated structure evaluation (multicase) - by Bioz Stars,
2026-10
90/100 stars
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other:Article Title: A new highly specific method for predicting the carcinogenic potential of pharmaceuticals in rodents using enhanced MCASE QSAR-ES software. Article Snippet: This report describes in detail a new quantitative structure–activity relational expert system (QSAR-ES) method for predicting the carcinogenic potential of pharmaceuticals and other organic chemicals in rodents, and a beta-test evaluation of its performance.. The method employs an optimized, computer-automated structure evaluation (MCASE) software program and new database modules which were developed under a Cooperative Research and Development Agreement (CRADA) between FDA and Multicase, Inc.. The beta-test utilized 126 compounds with carcinogenicity studies not included in control database modules and three sets of modules, including: A07-9 (Multicase, Inc.), AF1-4 (FDA-OTR/Multicase, Inc.), and AF5-8 (FDA-OTR/proprietary). Article Title: Quantitative structure-activity relationships for human health effects: commonalities with other endpoints. Article Snippet: These analyses have resulted in a number of expert system approaches to predict carcinogenicity, including those based on TOxicity Prediction by Computer Assisted Technology (TOPKAT) methodology [7,26], Article Title: Toward a comprehensive molecular design framework for reduced hazard. Article Snippet: The history of chemistry has been one of understanding the properties and transformations of matter.. Perhaps the most important aspect of this understanding is the properties that have an impact on human and environmental health and the transformations that take place in our bodies and in the biosphere.. Only through a mastery of this understanding will chemistry be able to genuinely design molecules that perform their intended function (e.g., therapeutic or industrial) and are safer for humans and the environment. Article Title: Structural and mechanistic bases for the induction of mitotic chromosomal loss and duplication ('malsegregation') in the yeast Saccharomyces cerevisiae: relevance to human carcinogenesis and developmental toxicology. Article Snippet: MultiCASE has the ability to automatically determine the structural features responsible for the biological activity of chemicals.. In the present study, 93 chemicals tested for their ability to induce chromosomal ‘malsegregation’ in the yeast Saccharomyces cereÕisiae were analyzed.. This ‘malsegregation’ mimics molecular events that occur during human development and carcinogenesis resulting in an effective loss of one chromosome of an autosomal pair and duplication of the homologue. |