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mouse anti human complement factor bb antibody  (Bio-Rad)


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    Structured Review

    Bio-Rad mouse anti human complement factor bb antibody
    Glomerular <t>complement</t> factor Bb and C3c deposits were detected in IgAN patients. (A, B) Mesangial positivity can be seen in the complement factor Bb and C3c stains on the glomerulus of a patients with IgA nephropathy. (C, D) No intensity can be detected in the complement factor Bb and C3c stains on the glomerulus of a patient with focal segmental sclerosis. (Magnification: 400X).
    Mouse Anti Human Complement Factor Bb Antibody, supplied by Bio-Rad, used in various techniques. Bioz Stars score: 91/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/complement+factor+b/Mouse+anti+Human+Complement+Factor+I/pmc08223746-74-9-15
    Average 91 stars, based on 10 article reviews
    mouse anti human complement factor bb antibody - by Bioz Stars, 2026-10
    91/100 stars

    Images

    1) Product Images from "Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA 1 Antibody in IgA Nephropathy Patients"

    Article Title: Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA 1 Antibody in IgA Nephropathy Patients

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2021.638309

    Glomerular complement factor Bb and C3c deposits were detected in IgAN patients. (A, B) Mesangial positivity can be seen in the complement factor Bb and C3c stains on the glomerulus of a patients with IgA nephropathy. (C, D) No intensity can be detected in the complement factor Bb and C3c stains on the glomerulus of a patient with focal segmental sclerosis. (Magnification: 400X).
    Figure Legend Snippet: Glomerular complement factor Bb and C3c deposits were detected in IgAN patients. (A, B) Mesangial positivity can be seen in the complement factor Bb and C3c stains on the glomerulus of a patients with IgA nephropathy. (C, D) No intensity can be detected in the complement factor Bb and C3c stains on the glomerulus of a patient with focal segmental sclerosis. (Magnification: 400X).

    Techniques Used:

    Decreased activation of alternative and terminal complement pathway and stabilized renal function after immunosuppression. (A) eGFR decreased slightly among patients who did not receive immunosuppression ( P = 0.028). (B) No change in eGFR among patients received immunosuppression. (C) UPCR tended to decrease slightly among patients who did not receive immunosuppression ( P = 0.051). (D) UPCR decreased significantly in patients who received immunosuppression ( P < 0.0001). (E) Plasma Gd-IgA 1 level tended to decrease 1 months after immunosuppression (N = 17, P = 0.0638) and 3~6 months after immunosuppression (N = 20, P = 0.0019). (F) Plasma C5a significantly decreased 1 (N = 17, P < 0.0001) and 3~6 months after immunosuppression (N = 20, P < 0.0001). (G) Plasma factor Ba level significantly decreased 1 (N = 17, P = 0.0008) and 3~6 months after immunosuppression (N = 20, P = 0.0004). UPCR, urinary protein to creatinine ratio; eGFR, estimated glomerular filtration rate.
    Figure Legend Snippet: Decreased activation of alternative and terminal complement pathway and stabilized renal function after immunosuppression. (A) eGFR decreased slightly among patients who did not receive immunosuppression ( P = 0.028). (B) No change in eGFR among patients received immunosuppression. (C) UPCR tended to decrease slightly among patients who did not receive immunosuppression ( P = 0.051). (D) UPCR decreased significantly in patients who received immunosuppression ( P < 0.0001). (E) Plasma Gd-IgA 1 level tended to decrease 1 months after immunosuppression (N = 17, P = 0.0638) and 3~6 months after immunosuppression (N = 20, P = 0.0019). (F) Plasma C5a significantly decreased 1 (N = 17, P < 0.0001) and 3~6 months after immunosuppression (N = 20, P < 0.0001). (G) Plasma factor Ba level significantly decreased 1 (N = 17, P = 0.0008) and 3~6 months after immunosuppression (N = 20, P = 0.0004). UPCR, urinary protein to creatinine ratio; eGFR, estimated glomerular filtration rate.

    Techniques Used: Activation Assay, Clinical Proteomics, Filtration

    Related Articles

    Staining:

    Article Title: Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA 1 Antibody in IgA Nephropathy Patients
    Article Snippet: .. For factor Bb staining, tissue sections were incubated with mouse anti-human complement factor Bb antibody (Bio-Rad, UK). .. After washing, tissue sections were incubated with the secondary fluorophore-conjugated goat anti-mouse secondary antibody (Abcam, Cambridge, UK).

    Article Title: Sequential Increase in Complement Factor I, iC3b, and Cells Expressing CD11b or CD14 in Cutaneous Vasculitis.
    Article Snippet: The complement iC3b was stained using 0.06μg/ml mouse monoclonal antihuman iC3b (neo) antibody (catalog number A209, IgG2bκ, Quidel® Corporation, San Diego, CA, USA). .. CFI was stained using 20μg/ml mouse monoclonal antihuman CFI antibody (catalog number MCA2615, BioRad, Oxon, UK). ..

    Article Title: Sequential Increase in Complement Factor I, iC3b, and Cells Expressing CD11b or CD14 in Cutaneous Vasculitis
    Article Snippet: The complement iC3b was stained using 0.06 μ g/ml mouse monoclonal antihuman iC3b (neo) antibody (catalog number A209, IgG2b κ , Quidel® Corporation, San Diego, CA, USA). .. CFI was stained using 20 μ g/ml mouse monoclonal antihuman CFI antibody (catalog number MCA2615, Bio-Rad, Oxon, UK). ..

    Incubation:

    Article Title: Alternative Complement Pathway Is Activated and Associated with Galactose-Deficient IgA 1 Antibody in IgA Nephropathy Patients
    Article Snippet: .. For factor Bb staining, tissue sections were incubated with mouse anti-human complement factor Bb antibody (Bio-Rad, UK). .. After washing, tissue sections were incubated with the secondary fluorophore-conjugated goat anti-mouse secondary antibody (Abcam, Cambridge, UK).



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