global screening array-24 v.30 gwas chip (INFINIUM Inc)
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Global Screening Array 24 V.30 Gwas Chip, supplied by INFINIUM Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Article Title: Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative
Journal: Alzheimer's & Dementia
doi: 10.1002/alz.70145
Figure Legend Snippet: Genomic profiling of iPSC lines from African Somatic and Stem Cell Bank. A, Workflow. B–I, Genetic analyses of iPSC. B, PCA of common genetic variants measured in unique iPSC lines (gray, cohort) compared to 1000 Genomes reference: AFR, AMR, EAS, EUR, SAS. C, Frequency of APOE genotypes among iPSC lines. D–I, PRS. D–E, Distribution of PRS represented using reference (salmon, REF) and iPSC samples (cyan, TRG). G–H, Distribution of PRS represented based on Nigerian ethnic group. D, G, PRS for AD including the APOE gene locus. E, H, PRS for AD excluding the APOE gene locus. F, I, PRS for PD. J, PCA of transcriptomic data generated from iPSCs (500 most variable gene transcripts). K, XIST, expressed on the inactivated X‐chromosome, in iPSC lines. Graphs represent CPM mean ± SEM. ****, p < 0.0001. Blue, female. Red, male. AD, Alzheimer's disease; AFR, Africans; AMR, admixed Americans; APOE , apolipoprotein E; CPM, counts per million; EAS, East Asians; EUR, Europeans; GWAS, genome‐wide association study; iPSC, induced pluripotent stem cell; PCA, principal component analysis; PD, Parkinson's disease; PRS, polygenic risk score; REF, reference; SAS, South Asian; SEM, standard error of the mean.
Techniques Used: Generated, GWAS
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Variants with a call rate <0.99 or Hardy-Weinberg equilibrium χ2 test with p-value<0.0001 were excluded using PLINK 1.912 GSA data was generated using the In Vitro:Article Title: Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative Article Snippet: Samples were analyzed by an Article Title: Genome‐Wide Meta‐Analysis Identifies Five Single‐Nucleotide Polymorphisms Associated With Both Vitiligo and Freckles in the Chinese Han Population Article Snippet: A genome‐wide association study (GWAS) utilizing the Article Title: Genome wide association study reveals novel associations with face morphology Article Snippet: Genotyping of the participants’ DNA for GWAS was utilized using microarray technology with Article Title: Genome‐Wide Meta‐Analysis Identifies Five Single‐Nucleotide Polymorphisms Associated With Both Vitiligo and Freckles in the Chinese Han Population Article Snippet: We first collected case cohorts of vitiligo and freckles, sequenced them using Article Title: Conserved roles of GATA4 and its target gene TBX2 in regulation of human cardiogenesis Article Snippet: The gDNA was karyotyped using the Article Title: Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant‐Like Behavior Article Snippet: Genotypic differences between parental and knockout isotype cell lines were identified after clonal expansion and a minimum of 6 months of in vitro culture using Article Title: Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies Article Snippet: Article Title: Article Snippet: Variants with a call rate <0.99 or Hardy-Weinberg equilibrium χ2 test with p-value<0.0001 were excluded using PLINK 1.912 GSA data was generated using the |