bioactive compounds (Selleck Chemicals)

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Selleck Chemicals bioactive compounds
Top 30 hit compounds from the <t> bioactive </t> high throughput screen with high SSMD and BHS (ranked by BHS).

Bioactive Compounds, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 73 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/bioactive+compound+library/Bioactive+Compound+Library-%E2%85%A1/pmc08971663-196-4-6
Average 94 stars, based on 73 article reviews

bioactive compounds - by Bioz Stars, 2026-10

94/100 stars

Images

1) Product Images from "In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets"

Article Title: In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets

Journal: Frontiers in Pharmacology

doi: 10.3389/fphar.2022.837756

Figure Legend Snippet: Top 30 hit compounds from the bioactive high throughput screen with high SSMD and BHS (ranked by BHS).

Techniques Used: High Throughput Screening Assay, Activation Assay

In Silico:

Article Title: Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy.
Article Snippet: To cite this article: Alice Viotti , Claudia Molinaro , Jessica Perego , Andrea Fossaghi , Chiara Parravicini , Eliana Laurenzano , Antonella Borreca , Marco Piccoli , Luigi Anastasia , Susanna Manenti , Annamaria Finardi , Alessandra Mandelli , Michela Matteoli , Ivano Eberini , Paola Panina , Gianvito Martino & Luca Muzio (05 Mar 2026): Duloxetine ameliorates cerebral ischemic injury by inhibiting autophagy, Autophagy, DOI: 10.1080/15548627.2026.2641616

Functional Assay:

other:

Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer
Article Snippet: Bioactive Compound Library , Selleckchem , Cat# L1700.

Concentration Assay:

Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer
Article Snippet: The Jin laboratory received research funds from Celgene Corporation, Levo Therapeutics, Inc., Cullgen, Inc., and Cullinan Oncology, Inc. None of these activities are related or relevant to the work presented herein. .. RCC10, RCC10-VHL, RCC10-HIF-1α/2α-DKO, 786-O, or 786- O -HIF-2α-KO cells (1 × 10 4 /well) were seeded onto 96-well plates for 12 h. For the initial screen, cells were treated with a small molecule library (L1700, Selleckchem) at a final concentration of 5 μM for 72 h. For the second screen, cells were treated for 72 h with vehicle or a 7-point, 2-fold serial dilution of chemicals (10 or 20 μM as the highest concentration) for IC50 determination. ..

Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies anti-m5C antibody Active motif 61479, RRID:AB_2793653 anti-HIF-1α antibody Bethyl Laboratories or home-made A300-286A, RRID:AB_2117114 anti-DNMT1 antibody Proteintech 24206-1-AP, RRID:AB_2879457 anti-DNMT3A antibody Proteintech 20954-1-AP, RRID:AB_10733339 anti-DNMT3B antibody Proteintech 26971-1-AP, RRID:AB_2880705 anti-caspase-10 antibody Proteintech 14311-1-AP, RRID:AB_2290777 anti-caspase-8 antibody Proteintech 13423-1-AP, RRID:AB_2068463 anti-TRAIL antibody Proteintech 27064-1-AP, RRID:AB_2880737 anti-DR4 antibody Proteintech 24063-1-AP, RRID:AB_2879421 anti-DcR2 antibody Proteintech 16781-1-AP, RRID:AB_2256181 anti-β-actin Proteintech 81115-1-RR, RRID:AB_2923704 anti-α-tubulin Proteintech 66031-1-Ig, RRID:AB_11042766 anti-DR5 antibody Cell Signaling Technology 69400S, RRID:AB_3718035 anti-cleaved-caspase-3 antibody Cell Signaling Technology 9661S, RRID:AB_2341188 anti-cleaved-caspase-7 antibody Cell Signaling Technology 8438S, RRID:AB_11178377 anti-PARP1 antibody Cell Signaling Technology 9542S, RRID:AB_2160739 anti-DNMT3L antibody Santa Cruz Biotechnology sc-393603, RRID:AB_2736834 normal mouse IgG Santa Cruz Biotechnology sc-2025, RRID:AB_737182 anti-HIF-2α antibody Home-made N/A Biological samples Human ccRCC tumor tissue UT Southwestern Medical Center UT Southwestern Medical Center (STU-2023-0366) Critical commercial assays Global DNA Methylation LINE-1 Kit Active motif Cat# 55017 BisulFlash DNA Modification Kit EpigenTek Cat# P-1026-050 DNeasy Blood & Tissue Kit Qiagen Cat# 69504 RNeasy mini kit Qiagen Cat# 74104 KAPA mRNA HyperPrep Kit Roche Cat# 08098123702 Bioactive Compound Library Selleckchem Cat# L1700 Chemicals and recombinant proteins SGI1027 MCE HY-13962 Necrostatin-1 MCE HY-15760 Ferrostatin-1 MCE HY-100579 .. In vitro chemical screens RCC10, RCC10-VHL, RCC10-HIF-1α/2α-DKO, 786-O, or 786-O-HIF-2α-KO cells (1 × 10 4 /well) were seeded onto 96-well plates for 12 h. For the initial screen, cells were treated with a small molecule library (L1700, Selleckchem) at a final concentration of 5 μM for 72 h. For the second screen, cells were treated for 72 h with vehicle or a 7-point, 2-fold serial dilution of chemicals (10 or 20 μM as the highest concentration) for IC50 determination. ..

Serial Dilution:

In Vitro:

DNA Methylation Assay:

Article Title: HIF-activated priming of TRAIL-induced cell death determines epigenetic vulnerability in kidney cancer.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies anti-m5C antibody Active motif 61479, RRID:AB_2793653 anti-HIF-1α antibody Bethyl Laboratories or home-made A300-286A, RRID:AB_2117114 anti-DNMT1 antibody Proteintech 24206-1-AP, RRID:AB_2879457 anti-DNMT3A antibody Proteintech 20954-1-AP, RRID:AB_10733339 anti-DNMT3B antibody Proteintech 26971-1-AP, RRID:AB_2880705 anti-caspase-10 antibody Proteintech 14311-1-AP, RRID:AB_2290777 anti-caspase-8 antibody Proteintech 13423-1-AP, RRID:AB_2068463 anti-TRAIL antibody Proteintech 27064-1-AP, RRID:AB_2880737 anti-DR4 antibody Proteintech 24063-1-AP, RRID:AB_2879421 anti-DcR2 antibody Proteintech 16781-1-AP, RRID:AB_2256181 anti-β-actin Proteintech 81115-1-RR, RRID:AB_2923704 anti-α-tubulin Proteintech 66031-1-Ig, RRID:AB_11042766 anti-DR5 antibody Cell Signaling Technology 69400S, RRID:AB_3718035 anti-cleaved-caspase-3 antibody Cell Signaling Technology 9661S, RRID:AB_2341188 anti-cleaved-caspase-7 antibody Cell Signaling Technology 8438S, RRID:AB_11178377 anti-PARP1 antibody Cell Signaling Technology 9542S, RRID:AB_2160739 anti-DNMT3L antibody Santa Cruz Biotechnology sc-393603, RRID:AB_2736834 normal mouse IgG Santa Cruz Biotechnology sc-2025, RRID:AB_737182 anti-HIF-2α antibody Home-made N/A Biological samples Human ccRCC tumor tissue UT Southwestern Medical Center UT Southwestern Medical Center (STU-2023-0366) Critical commercial assays Global DNA Methylation LINE-1 Kit Active motif Cat# 55017 BisulFlash DNA Modification Kit EpigenTek Cat# P-1026-050 DNeasy Blood & Tissue Kit Qiagen Cat# 69504 RNeasy mini kit Qiagen Cat# 74104 KAPA mRNA HyperPrep Kit Roche Cat# 08098123702 Bioactive Compound Library Selleckchem Cat# L1700 Chemicals and recombinant proteins SGI1027 MCE HY-13962 Necrostatin-1 MCE HY-15760 Ferrostatin-1 MCE HY-100579 ..

Modification:

Drug discovery:

Article Title: Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates.
Article Snippet: OCI-AML-3 cells were seeded in a sterile tissue culture 384-well plate (Corning, 3765) at 1000 cells and 50μl of media per well using an EL406 Microplate Washer Dispenser (Biotek). .. Screening library molecules (a collection of 1754 molecules derived from the Sigma LOPAC1280 and Selleck Bioactive Compound Library L1700 collections) weremaintained as a 3mMDMSO stock in Abgene storage 384- well plates (ThermoFisher Scientific; AB1055). ..

Review