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rt2 profiler pcr microarray [human cancer drug target (pahs-507zr)]  (Qiagen)


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    Qiagen rt2 profiler pcr microarray [human cancer drug target (pahs-507zr)]
    Rt2 Profiler Pcr Microarray [Human Cancer Drug Target (Pahs 507zr)], supplied by Qiagen, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/Human+PCR+Microarray/rt2+profiler+pcr+microarray++human+cancer+drug+target++rt2+profiler+pcr+microarray++human+cancer+drug+target++pahs+507zr++/pm33555494-144-10-24
    Average 90 stars, based on 1 article reviews
    rt2 profiler pcr microarray [human cancer drug target (pahs-507zr)] - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Real-time Polymerase Chain Reaction:

    Article Title: A bismuth diethyldithiocarbamate compound induced apoptosis via mitochondria-dependent pathway and suppressed invasion in MCF-7 breast cancer cells.
    Article Snippet: Interest in bismuth(III) dithiocarbamate complexes as potential drug candidates is increasing due to their low toxicity compared to other group 15 elements (pnictogen) of the periodic table.. Bismuth dithiocarbamate compounds have been reported to induce greater cytotoxicity in various human carcinoma cancer cell lines.. Using various in vitro cancerrelated assays, we investigated the antiproliferative activity of bismuth diethyldithiocarbamate, denoted as 1, against the MCF-7 human breast adenocarcinoma cell line and the effect on genes that may be involved in antiproliferation, apoptosis, DNA fragmentation, invasion and polyubiquitination functions.

    Microarray:

    Article Title: A bismuth diethyldithiocarbamate compound induced apoptosis via mitochondria-dependent pathway and suppressed invasion in MCF-7 breast cancer cells.
    Article Snippet: Interest in bismuth(III) dithiocarbamate complexes as potential drug candidates is increasing due to their low toxicity compared to other group 15 elements (pnictogen) of the periodic table.. Bismuth dithiocarbamate compounds have been reported to induce greater cytotoxicity in various human carcinoma cancer cell lines.. Using various in vitro cancerrelated assays, we investigated the antiproliferative activity of bismuth diethyldithiocarbamate, denoted as 1, against the MCF-7 human breast adenocarcinoma cell line and the effect on genes that may be involved in antiproliferation, apoptosis, DNA fragmentation, invasion and polyubiquitination functions.

    Article Title: Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion.
    Article Snippet: We previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells.. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(Pr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line.. 2–4 were found to exhibit IC50 values of 10.33 ± 0.06 μM, 1.07 ± 0.01 μM and 25.37 ± 0.12 μM, respectively, compared to that of cisplatin at 30.53 ± 0.23 μM.

    Polymerase Chain Reaction:

    Article Title: A bismuth diethyldithiocarbamate compound induced apoptosis via mitochondria-dependent pathway and suppressed invasion in MCF-7 breast cancer cells.
    Article Snippet: Interest in bismuth(III) dithiocarbamate complexes as potential drug candidates is increasing due to their low toxicity compared to other group 15 elements (pnictogen) of the periodic table.. Bismuth dithiocarbamate compounds have been reported to induce greater cytotoxicity in various human carcinoma cancer cell lines.. Using various in vitro cancerrelated assays, we investigated the antiproliferative activity of bismuth diethyldithiocarbamate, denoted as 1, against the MCF-7 human breast adenocarcinoma cell line and the effect on genes that may be involved in antiproliferation, apoptosis, DNA fragmentation, invasion and polyubiquitination functions.

    Article Title: More Related Gene Pathways to Vincristine-Induced Death Events in a Human T-Acute Lymphoblastic Leukemia Cell Line
    Article Snippet: Then, RNA treated with RNase- free DNase I, for removing genomic DNA, was converted to cDNA using First Strand cDNA Synthesis kit (Parstous, Iran, A101161; Thermo Fisher Scientific, USA, EN0521 ) according to manufacturer's instruction. .. Gene expression analysis by PCR array The Human cancer drug target RT 2 ProfilerTM PCR Array (Qiagen, USA, PAHS-507Z) was used to screen 84 gene expression changes of 17 pathways. ..

    Article Title: Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness
    Article Snippet: .. Human Cancer Drug Targets PCR Array (PAHS-507ZF-12; Qiagen GmbH, Hilden, Germany) and Brain Cancer miRNA PCR Array (MIHS-108Z; Qiagen GmbH, Hilden, Germany) were used to analyze the changes in cellular mRNA and miRNA expression profiles upon CDC7 inhibitor treatment. ..

    Article Title: PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma
    Article Snippet: Samples were transcribed with the RT2 First Strand Kit (Qiagen) according to the manufacturer’s protocol. .. Expression of a panel of 84 drug targetable genes as well as five housekeeping genes (ACTB, B2M, GAPDH, HPRT1, RPLP0) and seven positive control genes was evaluated by the Human Cancer Drug Targets RT2 Profiler PCR Array (PAHS507Z, Qiagen). .. The reaction was performed with the RT2 SYBR Green qPCR Master Mix (Qiagen) and all cell lines were run in triplicate.

    Article Title: Activation of NLRP3 inflammasome/pyroptosis by protease inhibitor atazanavir at high concentrations is mediated through mitochondrial dysfunction
    Article Snippet: QuantiTect Reverse Transcription kit (Qiagen, Germantown, MD) was used to reverse transcribe RNA to cDNA. .. To identify genes of interest, a 96 well RT 2 profiler PCR array human apoptosis kit (Qiagen, Germantown, MD) containing 84 apoptotic genes was used according to manufacturer’s instructions. .. Real-time quantitative PCR was performed in triplicate with a final volume of 25 μL per well consisting of 12.5 ng cDNA, 2x SYBR Green (Thermo Fisher Scientific, Waltham, MA), 10 μM forward primer, and 10 μM reverse primer.

    Article Title: Cytotoxicity of bismuth(III) dithiocarbamate derivatives by promoting a mitochondrial-dependent apoptotic pathway and suppressing MCF-7 breast adenocarcinoma cell invasion.
    Article Snippet: We previously reported that the bismuth(III) dithiocarbamate derivative, bismuth diethyldithiocarbamate (1) exhibited greater cytotoxicity while inducing apoptosis via the intrinsic pathway in MCF-7 cells.. We further evaluated the other bismuth(III) dithiocarbamate derivatives, Bi[S2CNR]3, with R = (CH2CH2OH)(Pr), (CH2)4, and (CH2CH2OH)(CH3), denoted as 2, 3, and 4, respectively, in the same MCF-7 cell line.. 2–4 were found to exhibit IC50 values of 10.33 ± 0.06 μM, 1.07 ± 0.01 μM and 25.37 ± 0.12 μM, respectively, compared to that of cisplatin at 30.53 ± 0.23 μM.

    Gene Expression:

    Article Title: A novel chalcone derivative, LQFM064, induces breast cancer cells death via p53, p21, KIT and PDGFRA.
    Article Snippet: Please cite this article as: Bruna Lannuce Silva Cabral, Artur Christian Garcia da Silva, Renato Ivan de Ávila, Alane Pereira Cortez, Rangel Magalhães Luzin, Luciano Morais Lião, Eric de Souza Gil, Gérman Sanz, Boniek G. Vaz, José R. Sabino, Ricardo Menegatti, Marize Campos Valadares , A novel chalcone derivative, LQFM064, induces breast cancer cells death via p53, p21, KIT and PDGFRA, European Journal of Pharmaceutical Sciences (2017), doi: 10.1016/j.ejps.2017.06.018

    Article Title: More Related Gene Pathways to Vincristine-Induced Death Events in a Human T-Acute Lymphoblastic Leukemia Cell Line
    Article Snippet: Then, RNA treated with RNase- free DNase I, for removing genomic DNA, was converted to cDNA using First Strand cDNA Synthesis kit (Parstous, Iran, A101161; Thermo Fisher Scientific, USA, EN0521 ) according to manufacturer's instruction. .. Gene expression analysis by PCR array The Human cancer drug target RT 2 ProfilerTM PCR Array (Qiagen, USA, PAHS-507Z) was used to screen 84 gene expression changes of 17 pathways. ..

    Expressing:

    Article Title: Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness
    Article Snippet: .. Human Cancer Drug Targets PCR Array (PAHS-507ZF-12; Qiagen GmbH, Hilden, Germany) and Brain Cancer miRNA PCR Array (MIHS-108Z; Qiagen GmbH, Hilden, Germany) were used to analyze the changes in cellular mRNA and miRNA expression profiles upon CDC7 inhibitor treatment. ..

    Article Title: PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma
    Article Snippet: Samples were transcribed with the RT2 First Strand Kit (Qiagen) according to the manufacturer’s protocol. .. Expression of a panel of 84 drug targetable genes as well as five housekeeping genes (ACTB, B2M, GAPDH, HPRT1, RPLP0) and seven positive control genes was evaluated by the Human Cancer Drug Targets RT2 Profiler PCR Array (PAHS507Z, Qiagen). .. The reaction was performed with the RT2 SYBR Green qPCR Master Mix (Qiagen) and all cell lines were run in triplicate.

    Positive Control:

    Article Title: PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma
    Article Snippet: Samples were transcribed with the RT2 First Strand Kit (Qiagen) according to the manufacturer’s protocol. .. Expression of a panel of 84 drug targetable genes as well as five housekeeping genes (ACTB, B2M, GAPDH, HPRT1, RPLP0) and seven positive control genes was evaluated by the Human Cancer Drug Targets RT2 Profiler PCR Array (PAHS507Z, Qiagen). .. The reaction was performed with the RT2 SYBR Green qPCR Master Mix (Qiagen) and all cell lines were run in triplicate.



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    Image Search Results


    Effects of melatonin and radiation on breast cancer miRNA expression microarray. Total RNA from MCF-7 cells was extracted 4 h after radiation, reverse transcribed and used for RT-PCR analysis using Human Breast Cancer microarray (MIHS-109ZA). ( a – c ) Heatmaps of relative normalized expression between different treatments ( a ) M vs. C; ( b ) R vs. C; ( c ) M + R vs. C; ( d ) Bar chart of relative normalized expression (ΔCt) of selected miRNAs. a: miR20a; b: miR-20b; c: miR-17; d: miR-141; e: miR-15a; f: miR-19a; g: miR29a; h: miR-93; i: miR-10b. C: Control; M: Melatonin pre-treated cells (1 nM); R: Radiated cells (8 Gy); M + R: Melatonin pre-treated and radiated cells.

    Journal: Biomedicines

    Article Title: Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells

    doi: 10.3390/biomedicines10051088

    Figure Lengend Snippet: Effects of melatonin and radiation on breast cancer miRNA expression microarray. Total RNA from MCF-7 cells was extracted 4 h after radiation, reverse transcribed and used for RT-PCR analysis using Human Breast Cancer microarray (MIHS-109ZA). ( a – c ) Heatmaps of relative normalized expression between different treatments ( a ) M vs. C; ( b ) R vs. C; ( c ) M + R vs. C; ( d ) Bar chart of relative normalized expression (ΔCt) of selected miRNAs. a: miR20a; b: miR-20b; c: miR-17; d: miR-141; e: miR-15a; f: miR-19a; g: miR29a; h: miR-93; i: miR-10b. C: Control; M: Melatonin pre-treated cells (1 nM); R: Radiated cells (8 Gy); M + R: Melatonin pre-treated and radiated cells.

    Article Snippet: We next analyzed the influence of melatonin on the expression of multiple genes and miRNAs involved in breast cancer using a gene microarray (Human Breast Cancer RT 2 Profiler TM PCR Array) and a Human Breast Cancer miRNA microarray (MIHS-109ZA, Qiagen, Germantown, MD, USA).

    Techniques: Expressing, Microarray, Reverse Transcription, Reverse Transcription Polymerase Chain Reaction, Control