azd8055 (Selleck Chemicals)

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Selleck Chemicals azd8055

Cell motility study combining live-cell tracking with PACIFIC. (a) Workflow of the experiment. (b) Cell movement trajectories of living cells without perturbation, with EGFR inhibition (erlotinib), and with AKT inhibition <t>(AZD8055).</t> (c) Scatter plot of protein expression levels and the confinement ratio extracted from the single cells. (d) t-SNE plot of the single-cell data set followed by nearest neighbor clustering to partition the single-cell data into phenotypical subpopulations. (e) Cell movement trajectories of living cells without perturbation, with p70S6K inhibition (LY2584702), and combinations of LY2584702 with EGFR or AKT inhibitors. (f) Scatter plot of confinement ratio extracted from live-cell tracking. (**, p < 0.01; ***, p < 0.001).

Azd8055, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 346 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/3d+cell+tracking+algorithm/AZD8055/pmc10288499-175-1-7
Average 96 stars, based on 346 article reviews

azd8055 - by Bioz Stars, 2026-11

96/100 stars

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1) Product Images from "Multiplex Protein Imaging through PACIFIC: Photoactive Immunofluorescence with Iterative Cleavage"

Article Title: Multiplex Protein Imaging through PACIFIC: Photoactive Immunofluorescence with Iterative Cleavage

Journal: ACS Bio & Med Chem Au

doi: 10.1021/acsbiomedchemau.3c00018

Figure Legend Snippet: Cell motility study combining live-cell tracking with PACIFIC. (a) Workflow of the experiment. (b) Cell movement trajectories of living cells without perturbation, with EGFR inhibition (erlotinib), and with AKT inhibition (AZD8055). (c) Scatter plot of protein expression levels and the confinement ratio extracted from the single cells. (d) t-SNE plot of the single-cell data set followed by nearest neighbor clustering to partition the single-cell data into phenotypical subpopulations. (e) Cell movement trajectories of living cells without perturbation, with p70S6K inhibition (LY2584702), and combinations of LY2584702 with EGFR or AKT inhibitors. (f) Scatter plot of confinement ratio extracted from live-cell tracking. (**, p < 0.01; ***, p < 0.001).

Techniques Used: Cell Tracking Assay, Inhibition, Expressing

Bioprocessing:

Article Title: Epigenetic Activity of Cancer Therapy Drugs Revealed by HeLa TI Cell-Based Assay.
Article Snippet: .. Targeted Therapy mTORC1 inhibitors: AZD8055 (AZD, CAS 1009298-09-2, LC Laboratories, Woburn, MA, USA), rapamycin (RAPA, CAS 53123-88-9, SelleckChem); PI3K inhibitors: LY294002 (LY, CAS 154447-36-6, SelleckChem), wortmannin (WMN, CAS 19545-26-7, SelleckChem); kinase inhibitor: flavopiridol (FVP, CAS 146426-40-6, SelleckChem); proteasome inhibitor: bortezomib (BTZ, CAS 179324-69-7, MedChemExpress); selective estrogen receptor modulators: tamoxifen (TAM, CAS 10540-29-1, Macklin), fulvestrant (FVT, CAS 129453-61-8, Hexal, Holzkirchen, Germany); Hedgehog pathway inhibitor: vismodegib (VIS, CAS 879085-55-9, Roche Holding, Basel, Switzerland); PARP inhibitor: olaparib (OPB, CAS 763113-22-0, AstraZeneca, Cambridge, UK); monoclonal antibodies: cetuximab (CTX, CAS 205923-56-4, Merck), olaratumab (OLA, CAS 1024603-93-7, Eli Lilly, Indianapolis, IN, USA), bevacizumab (BVZ, CAS 216974-75-3, BioCad). ..

Article Title: Epigenetic Activity of Cancer Therapy Drugs Revealed by HeLa TI Cell-Based Assay
Article Snippet: .. mTORC1 inhibitors: AZD8055 (AZD, CAS 1009298-09-2, LC Laboratories, Woburn, MA, USA), rapamycin (RAPA, CAS 53123-88-9, SelleckChem); PI3K inhibitors: LY294002 (LY, CAS 154447-36-6, SelleckChem), wortmannin (WMN, CAS 19545-26-7, SelleckChem); kinase inhibitor: flavopiridol (FVP, CAS 146426-40-6, SelleckChem); proteasome inhibitor: bortezomib (BTZ, CAS 179324-69-7, MedChemExpress); selective estrogen receptor modulators: tamoxifen (TAM, CAS 10540-29-1, Macklin), fulvestrant (FVT, CAS 129453-61-8, Hexal, Holzkirchen, Germany); Hedgehog pathway inhibitor: vismodegib (VIS, CAS 879085-55-9, Roche Holding, Basel, Switzerland); PARP inhibitor: olaparib (OPB, CAS 763113-22-0, AstraZeneca, Cambridge, UK); monoclonal antibodies: cetuximab (CTX, CAS 205923-56-4, Merck), olaratumab (OLA, CAS 1024603-93-7, Eli Lilly, Indianapolis, IN, USA), bevacizumab (BVZ, CAS 216974-75-3, BioCad). ..

other:

Article Title: CRISPR knockout screens reveal JUN as the master mediator of resistance to MAPK inhibition in KRAS-mutant pancreatic cancer.
Article Snippet: RMC-6236 and SP-600125 were purchased from MedKoo.

Article Title: Stress granule dynamics govern TOR reactivation and growth recovery during post-heat stress adaptation
Article Snippet: Torin2 (1 μM, Tocris Bioscience, catalog no. 4248), AZD8055 (1 μM, Selleckchem, catalog no. S1555), and CHX (200 ng/μl; INALCO, catalog no. 1758-9310) were dissolved in dimethyl sulfoxide (DMSO).

Article Title: CRISPR knockout screens reveal JUN as the master mediator of resistance to MAPK inhibition in KRAS-mutant pancreatic cancer
Article Snippet: AZD8055 (S1555) was purchased from Selleck Chemicals®.

Concentration Assay:

Article Title: Lysosomal phosphoinositide turnover acts upstream of RagGTPase–mTORC1 and controls muscle growth
Article Snippet: .. The following drugs were diluted in DMSO to obtain the appropriate concentration: the pan-PI3Ks inhibitors wortmannin (5 mM; W1628, Sigma) and LY294002 (5 mM; L9908, Sigma), the mTORC1-ATP competitors torin 1 (200 nM; 475991, Sigma) and AZD8055 (200 nM; S1555, Selleckchem), the p70 ribosomal S6 kinase (S6K1) inhibitor PF-4708671 (10 mM; PZ0143, Sigma), the eIF2α inhibitor salubrinal (10 mM; SML0951, Sigma), the Vps34 inhibitor IN1 (0.25–1 mM; S7980, Selleck) and the PikFyve inhibitor Apilm (0.05–1 mM; S0785, Selleck). .. The pulse–chase assay was performed using CHX at 100 μg ml −1 (Sigma–Aldrich).

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