2d biomimetic peptide/ac-bp functionalized titanium substrates (BioMimetic Therapeutics)
90
Structured Review
BioMimetic Therapeutics
2d biomimetic peptide/ac-bp functionalized titanium substrates
2d Biomimetic Peptide/Ac Bp Functionalized Titanium Substrates, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/2d+functionality/pmc07658495-43-5-6?v=BioMimetic+Therapeutics
Average 90 stars, based on 1 article reviews
2d Biomimetic Peptide/Ac Bp Functionalized Titanium Substrates, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/2d+functionality/pmc07658495-43-5-6?v=BioMimetic+Therapeutics
Average 90 stars, based on 1 article reviews
2d biomimetic peptide/ac-bp functionalized titanium substrates - by Bioz Stars,
2026-08
90/100 stars
Images
1) Product Images from "Surface decoration of development-inspired synthetic N-cadherin motif via Ac-BP promotes osseointegration of metal implants"
Article Title: Surface decoration of development-inspired synthetic N-cadherin motif via Ac-BP promotes osseointegration of metal implants
Journal: Bioactive Materials
doi: 10.1016/j.bioactmat.2020.11.002
Figure Legend Snippet: (A) Diagram illustrating biomimetic peptide/acryloyl-bisphosphonate (Ac-BP) conjugation and hMSCs seeding on 2D titanium substrates, (B) osseointegration in the site of the implantation with the biomimetic peptide/Ac-BP conjugated titanium screws in rabbit tibiae/femurs ( in vivo ). (C) And the reaction of biomimetic peptide conjugation to TiO 2 substrates with Ac-BP.
Techniques Used: Conjugation Assay, In Vivo
Figure Legend Snippet: (A) Gene expression of osteogenic markers (Osterix and Osteomodulin) in the hMSCs seeded on the biomimetic peptide/Ac-BP conjugated TiO 2 surface after osteogenic differentiation for 4 days and 12 days. (*p value < 0.05, **p value < 0.01 vs. Cad + RGD, n = 4). (B) RUNX2 immunostaining of the hMSCs seeded on 2D titanium substrates (Control), and the substrates conjugated with Ac-BP and N-cadherin/RGD mimetic peptide (Cad + RGD), Scrambled sequence N-cadherin/RGD mimetic peptide (Scram + RGD), or RGD mimetic peptide (RGD) after 4 days of osteogenic culture. (Scale bar = 250 μm) (C) The atomic force microscope (AFM) images of group Cad + RGD, Scram + RGD, RGD and control. The untreated titanium substrates were measured as control (The test area of AFM analysis is 10 μm*10 μm as shown in figure). (D) X-ray photoelectron spectroscopy (XPS) spectra of corresponding groups (a–d) to the AFM scanning result, showing P–O peaks after the reaction with biomimetic peptide/acryloyl-bisphosphonate and washed with distilled water. While images (e–h) also show the grouped peaks measured 12 days after the surface coating reaction, which demonstrated the successful reaction of Ac-BP and biomimetic peptide on the titanium surface by forming titanium-oxygen-phosphorus group (Ti–P–O), and the coating would last after 12 days cultivation (n = 3).
Techniques Used: Gene Expression, Immunostaining, Control, Sequencing, Microscopy, Spectroscopy