selective xpo1 inhibitor (MedChemExpress)
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MedChemExpress
selective xpo1 inhibitor
Selective Xpo1 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 25 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/17536/Selinexor/pmc12924737-277-2-8
Average 94 stars, based on 25 article reviews
Selective Xpo1 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 25 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/17536/Selinexor/pmc12924737-277-2-8
Average 94 stars, based on 25 article reviews
selective xpo1 inhibitor - by Bioz Stars,
2026-10
94/100 stars
Images
1) Product Images from "CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma"
Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma
Journal: iScience
doi: 10.1016/j.isci.2026.114840
Figure Legend Snippet: Knockdown of XPO1 inhibited the invasion and migration abilities of ccRCC cells (A) The Venn diagram obtained by taking the intersection of the relevant gene sets of CCT3 and RB1 after screening. (B) Expression level of XPO1 in clear cell RCC from the TCGA database. (C) The immunohistochemical results of XPO1 in ccRCC and normal renal tissue in the HPA database. (D) A Kaplan-Meier curve illustrates OS in patients with ccRCC from low and high XPO1 expression groups. (E) The promoter methylation level of XPO1 in KIRC from the TCGA database. (F) Western blot analysis was performed to assess the protein expression of XPO1 in CCT3-depleted cells. (G) Using Spearman correlation analysis, the correlation between Gene CCT3 and XPO1 expression, and the correlation between XPO1 and RB1 expression. (H) Wound-healing assay indicates that XPO1 knockdown suppresses the viability of 786-O and 769-P cells. (I) Transwell assay indicates impaired abilities of migration and invasion of 769-P and 786-O cells. (Scale bars, 100 μm, all data were shown as the mean ± SD ( n = 3 per group), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001). Two-tailed Student’s t test for B and E. Student’s t test for F, H, and I.
Techniques Used: Knockdown, Migration, Expressing, Immunohistochemical staining, Methylation, Western Blot, Wound Healing Assay, Transwell Assay, Two Tailed Test
Figure Legend Snippet: The reduction of XPO1 induces cellular senescence in ccRCC cells (A) Western blot analysis was performed to assess the protein expression of CDK4, CyclinD, p-Rb (Ser807/811) in XPO1 knockdown cells. (B) The mRNA expression levels of senescence-associated genes, including interleukin 1 A, TNF, CDK2, CDK4, and CDK6 in XPO1-depleted cells were examined by qRT-PCR. (C) Changes of SA-β-gal activity in XPO1-knockdown cells. Data represent the percentage of cells staining positive for SA-β-gal ±SD. (D) Cell cycle analysis calculated the distribution of the cells in G1, S, and G2/M phases. (E) The proliferative abilities of 769-P and 786-O cells, which were treated with the XPO1 inhibitor Selinexor, were measured with an EdU staining assay. (Scale bars, 100 μm, all data were shown as the mean ± SD ( n = 3 per group), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). Student’s t test.
Techniques Used: Western Blot, Expressing, Knockdown, Quantitative RT-PCR, Activity Assay, Staining, Cell Cycle Assay
Figure Legend Snippet: CCT3 regulates RB1 activity by influencing the stability of the XPO1 protein (A) The Co-IP was performed to analyze the endogenous interaction between CCT3 and XPO1 in ccRCC cells. protein pellets were analyzed by Western blot with anti-CCT3 and anti-XPO1 antibodies. (B) Pull-down of CCT3, XPO1, and CCT3 with GST-tagged was analyzed by Western Blot. (C) Western blot analysis of XPO1 in control or CCT3–knockdown cells treated with CHX for the times indicated. (D) Western blot analysis of XPO1 in control or CCT3–knockdown cells treated with BafA1. (E) Western blot analysis of XPO1 in control or CCT3–knockdown cells treated with MG132. (F) Visualization results of the CCT3 and XPO1 molecular docking. (All data were shown as the mean ± SD ( n = 3 per group), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). One-way ANOVA for C, Student’s t test for D and E.
Techniques Used: Activity Assay, Co-Immunoprecipitation Assay, Western Blot, Control, Knockdown
Figure Legend Snippet: Rescue experiments demonstrate the effects of CCT3 overexpression and XPO1 knockdown on cell function (A) Western blot was used to detect the expression of RB1 and Cyclin D in nuclear and cytoplasmic fractions of cells. (B) Western blot analysis was performed to assess the protein expression of Cyclin D, p-Rb (Ser807/811) in the rescue assay. (C) Senescence β-Galactosidase Staining in rescue assay. (D) A healing assay was performed in the rescue assay. (E) Transwell assay was performed in the rescue assay. (Scale bars, 100 μm, all data were shown as the mean ± SD ( n = 3 per group), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). One-way ANOVA for D, E.
Techniques Used: Over Expression, Knockdown, Cell Function Assay, Western Blot, Expressing, Rescue Assay, Staining, Transwell Assay
Figure Legend Snippet: Knockdown of CCT3 combined with a selective XPO1 inhibitor can promote cellular senescence to suppress tumor progression in vivo (A) Nude mice were used to establish a tumor xenograft model utilizing CCT3 knockdown cell lines and the selective XPO1 inhibitor, Selinexor. (B and C) The tumor volumes and tumor weight of each group. (D) Western blot analysis was performed to assess the protein expression of p53, Cyclin D, CDK4, and PCNA in tissue. (E and F) The immunohistochemistry and immunofluorescence assays of Ki67. (Scale bars, 100 μm. All data were shown as the mean ± SD ( n = 3 per group), ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). Repeated measures ANOVA for B and C. One-way ANOVA for D and E.
Techniques Used: Knockdown, In Vivo, Western Blot, Expressing, Immunohistochemistry, Immunofluorescence
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Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. 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Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. 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Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Co-Immunoprecipitation Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Blocking Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Quantitative RT-PCR:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Knock-Out:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Expressing:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Two Tailed Test:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Knockdown:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Activity Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Cell Cycle Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The In Vivo:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Immunohistochemistry:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Migration:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Immunohistochemical staining:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Methylation:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Wound Healing Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Transwell Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Over Expression:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Cell Function Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The Rescue Assay:Article Title: Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors. Article Snippet: icillin-Streptomycin Thermo Fisher Scientific 15140122 Preclinical/Clinical Compound Library Selleck Chemicals L3900 Recovery Cell Culture Freezing Medium Thermo Fisher Scientific 12648010 Regorafenib Article Title: XPO1 inhibitor selinexor suppresses homologous recombination by inhibiting E2F7 nuclear export in acute myeloid leukemia. Article Snippet: Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.Cells were maintained at 37 °C with 5% CO2, authenticated by STR profiling, and routinely tested for mycoplasma.. Selinexor (Cat. Article Title: Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria-Induced Apoptosis Pathway. Article Snippet: Materials for cell culture were sourced from Nest (Wuxi, China).Materials for cell culture were sourced from Nest (Wuxi, China).. The Venetoclax and Article Title: CRM1-dependent nuclear export of TRIM28 promotes MAVS K48-linked ubiquitination and suppresses RIG-I-mediated antiviral response Article Snippet: Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.Polyinosinic-polycytidylic acid (poly I:C) was obtained from InvivoGen.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.MG132 was used at a concentration of 100 μM for an 8-hour treatment, while BafA1 was used at 200 nM for a 24-hour treatment.. Article Title: CCT3-mediated regulation of XPO1/RB1 axis stability promotes cellular senescence and tumor progression in clear cell renal carcinoma Article Snippet: The |
