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Rockland Immunochemicals
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Absolute Biotech Inc
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Gentex Corporation
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Biomol GmbH
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Cedarlane
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This gene encodes the catalytic subunit of the DNA dependent protein kinase DNA PK It functions with the Ku70 Ku80 heterodimer protein in DNA double strand break repair and recombination The protein encoded is a
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Rabbit Anti Human Phospho DNA PK T2609 Antibody 400 µl
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Image Search Results
Journal: Journal of Neuropathology and Experimental Neurology
Article Title: Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons
doi: 10.1093/jnen/nlx097
Figure Lengend Snippet: Antibodies and Antisera Used in the Current Study to Evaluate Candidate Detergent-Insoluble Pathogenic Proteins
Article Snippet: PRKDC(
Techniques:
Journal: Journal of Neuropathology and Experimental Neurology
Article Title: Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons
doi: 10.1093/jnen/nlx097
Figure Lengend Snippet: Immunohistochemistry for PRKDC in human brains using 4 separate antisera. Among all the candidate novel DIPPs, the strongest immunohistochemical staining was found using antisera against PRKDC. The antiserum raised against nonphosphorylated PRKDC provided relatively indistinct staining of cellular features, and high background (A). By contrast, all 3 antisera raised against phosphorylated epitopes within PRKDC showed immunostaining of what appeared to be clear-cut inclusion bodies: anti-PRKDC-P (S2056) (B, C); anti-PRKDC-P (T2647) (D); and anti-PRKDC-P (T2609) (E). These results are representative of a tendency to stain inclusion bodies (yellow arrows) in dementia cases. By contrast, nondemented cases showed no inclusion body-like structures, and generally immunostained nuclear profiles, as expected (C). In addition to immunostaining inclusion body-like structures, the anti-PRKDC-P antisera also highlighted roundish cytoplasmic structures in cognitively impaired subjects, such as the one in the inset in panel D. Note also the presence of neuropil thread-like staining (E). Scale bars: A–E = 20 μm.
Article Snippet: PRKDC(
Techniques: Immunohistochemistry, Immunohistochemical staining, Staining, Immunostaining