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Image Search Results
Journal: Journal of the American Society of Nephrology : JASN
Article Title: A Spleen Tyrosine Kinase Inhibitor Reduces the Severity of Established Glomerulonephritis
doi: 10.1681/ASN.2009030263
Figure Lengend Snippet: Effect of Syk inhibitor on IgG-stimulated production of MCP-1 from WKY rat mesangial cells and macrophages is shown. (A) There was a dose-dependent reduction of MCP-1 by incubation of mesangial cells with R406: 386 pg/ml (365 to 399 pg/ml) in medium only versus 200 pg/ml (186 to 210 pg/ml) after incubation with 1 μM R406 (P < 0.005, Kruskal-Wallis test). The results are representative of three experiments. (B) There was a dose-dependent reduction of MCP-1 by incubation of bone marrow–derived macrophages with R406: 1295 ng/ml (1152 to 1836 ng/ml) in medium only versus 25 ng/ml (19 to 29 ng/ml) after incubation with 2 μM R406 (P < 0.0005).
Article Snippet: The
Techniques: Incubation, Derivative Assay