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Image Search Results
Journal: Frontiers in Immunology
Article Title: New Insights into the Role of Macrophages in Adipose Tissue Inflammation and Fatty Liver Disease: Modulation by Endogenous Omega-3 Fatty Acid-Derived Lipid Mediators
doi: 10.3389/fimmu.2011.00049
Figure Lengend Snippet: Schematic representation of the interplay between adipose tissue, skeletal muscle, and the liver in the obesity-related perturbation of systemic metabolic control . Obesity results in expansion of adipose tissue mass that eventually leads to a characteristic inflammatory response driven by macrophage infiltration and aberrant production and release of pro-inflammatory adipokines, accompanied by a reduction in the anti-inflammatory and insulin-sensitizing adipokine, adiponectin. This altered profile of adipokine secretion leads to insulin resistance (IR) in the liver and skeletal muscle, which are the major organs contributing to the development of peripheral insulin resistance. Hepatic insulin resistance also triggers the progression of hepatic steatosis or fatty liver.
Article Snippet: Second, increased secretion of pro-inflammatory and insulin-resistant
Techniques: Control