Journal: Current Developments in Nutrition

Article Title: Cannabidiol and Intestinal Motility: a Systematic Review

doi: 10.1016/j.cdnut.2023.101972

Figure Lengend Snippet: Characteristics and findings of the effect of CBD on intestinal motility.

Article Snippet: Lin et al., 2011 [ ] , in vitro/ex vivo & in vivo , Charcoal meal passage (C57/BL mice, % transit of SI) SI myoelectrical activity (frequency and amplitude, Sprague-Dawley rat jejunum) Spontaneous contraction response (% control, Sprague-Dawley rat ileum and colon ) Membrane potential (mouse jejunum) , LPS , In vivo: 1 mg/kg, i.p. In vitro: 0.001–0.1 μM , SI myoelectrical spiking activity (SA) (% of control frequency & amplitude), in vivo : LPS + CBD: Frequency and amplitude significantly higher than LPS∗∗ Passage rate (SI transit % of control), in vivo: LPS: 74.2 ± 3.6%∗ Significantly decreased compared to control LPS + CBD: 124.5 ± 9.4%∗ Significantly increased compared to LPS Spontaneous Contraction response (% of control), in vitro : LPS (ileum): 59.6 ± 7.4∗∗ Significantly decreased compared to control LPS (colon): 151.1 ± 27.6∗ Significantly increased compared to control LPS + CBD (0.001 μM∗, 0.01 μM∗∗, 0.1 μM∗∗ mol/L): Significantly increased % contraction compared to LPS group in both the ileum and colon tissue Membrane potential (MP), in vitro : CBD did not significantly affect the MP or amplitude of slow waves. , LPS ↓ frequency and amplitude of SA CBD pretreatment ↑ frequency and amplitude of SA in LPS treated rats LPS ↓ charcoal meal transit % CBD pretreatment ↑ meal transit % in LPS treated mice CBD normalized spontaneous contraction response in mouse ileum and colon segments CBD did not affect membrane potential.

Techniques: Activity Assay, Control, In Vivo, In Vitro, Expressing, Extraction, Marker, Inhibition, Mouse Assay, Membrane, Fluorescence, Purification, Capsules, Cannabis

Journal: BMC Genomics

Article Title: EST analysis on pig mitochondria reveal novel expression differences between developmental and adult tissues

doi: 10.1186/1471-2164-8-367

Figure Lengend Snippet: Overview of Libraries

Article Snippet: ill , Intestine (S) , Small intest, illeum , 147.

Techniques: Muscles, Proximity Ligation Assay, Membrane

Journal: The Febs Journal

Article Title: Glycaemic sugar metabolism and the gut microbiota: past, present and future

doi: 10.1111/febs.17293

Figure Lengend Snippet: Overview of current trials investigating small intestinal microbiota, including novel sampling techniques and the influence of dietary carbohydrates. Extracted from the WHO international clinical trials registry platform and the ClinicalTrials.gov database.

Article Snippet: Elucidating the Role of Human Small Intestine Microbiota in Interpersonal Differences in Glycemic Responses Upon Consumption of Food Products. (GLYSIMI) – NTC05120661 , Interventional, randomised , To investigate the role of the human small intestine microbiota in regulating postprandial glycemic responses towards food products. Participants will be intubated with a naso‐jejunum catheter for additional analysis including (bacterial) degradation products , 20 , Wageningen University, Wageningen, Gelderland, the Nederlands , December 2021, recruiting.

Techniques: Sampling, Clinical Proteomics, Western Blot, Comparison, Diagnostic Assay, Biomarker Discovery, Capsules