iox-1 Search Results


iox1  (Tocris)
89
Tocris iox1
Iox1, supplied by Tocris, used in various techniques. Bioz Stars score: 89/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 89 stars, based on 1 article reviews
iox1 - by Bioz Stars, 2026-04
89/100 stars
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medchemexpress 5  (MedChemExpress)
94
MedChemExpress medchemexpress 5
Medchemexpress 5, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
medchemexpress 5 - by Bioz Stars, 2026-04
94/100 stars
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h9c2 cells  (Selleck Chemicals)
94
Selleck Chemicals h9c2 cells
Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in <t>H9C2</t> cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.
H9c2 Cells, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 94 stars, based on 1 article reviews
h9c2 cells - by Bioz Stars, 2026-04
94/100 stars
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8-hydroxy-5quinoline carboxylic acid (iox1, cayman chemicals, cat# 11572)  (Cayman Chemical)
90
Cayman Chemical 8-hydroxy-5quinoline carboxylic acid (iox1, cayman chemicals, cat# 11572)
Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in <t>H9C2</t> cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.
8 Hydroxy 5quinoline Carboxylic Acid (Iox1, Cayman Chemicals, Cat# 11572), supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/8-hydroxy-5quinoline carboxylic acid (iox1, cayman chemicals, cat# 11572)/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
8-hydroxy-5quinoline carboxylic acid (iox1, cayman chemicals, cat# 11572) - by Bioz Stars, 2026-04
90/100 stars
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iox1.8  (emka TECHNOLOGIES S A S)
90
emka TECHNOLOGIES S A S iox1.8
Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in <t>H9C2</t> cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.
Iox1.8, supplied by emka TECHNOLOGIES S A S, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/iox1.8/product/emka TECHNOLOGIES S A S
Average 90 stars, based on 1 article reviews
iox1.8 - by Bioz Stars, 2026-04
90/100 stars
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iox-1  (Topscience Co Ltd)
90
Topscience Co Ltd iox-1
Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in <t>H9C2</t> cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.
Iox 1, supplied by Topscience Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/iox-1/product/Topscience Co Ltd
Average 90 stars, based on 1 article reviews
iox-1 - by Bioz Stars, 2026-04
90/100 stars
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iox1 (1)  (Verlag GmbH)
90
Verlag GmbH iox1 (1)
Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in <t>H9C2</t> cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.
Iox1 (1), supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/iox1 (1)/product/Verlag GmbH
Average 90 stars, based on 1 article reviews
iox1 (1) - by Bioz Stars, 2026-04
90/100 stars
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iox1  (Active Motif)
90
Active Motif iox1
Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in <t>H9C2</t> cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.
Iox1, supplied by Active Motif, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/iox1/product/Active Motif
Average 90 stars, based on 1 article reviews
iox1 - by Bioz Stars, 2026-04
90/100 stars
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31 ioxaglate (iox1−)  (Mallinckrodt)
90
Mallinckrodt 31 ioxaglate (iox1−)
Chemical structures of the cationic (Gd(DTPA)Lys2 (Gd4+) & CA4+) and anionic (Gadopentetic acid (Gd2−) & <t>Ioxaglate</t> <t>(Iox1−))</t> MRI and CT contrasts agents, respectively, overlaid a drawing of a human hand noting the metacarpal phalangeal joint (MCPJ) under study.
31 Ioxaglate (Iox1−), supplied by Mallinckrodt, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/31 ioxaglate (iox1−)/product/Mallinckrodt
Average 90 stars, based on 1 article reviews
31 ioxaglate (iox1−) - by Bioz Stars, 2026-04
90/100 stars
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iox1  (Merck & Co)
90
Merck & Co iox1
Chemical structures of the cationic (Gd(DTPA)Lys2 (Gd4+) & CA4+) and anionic (Gadopentetic acid (Gd2−) & <t>Ioxaglate</t> <t>(Iox1−))</t> MRI and CT contrasts agents, respectively, overlaid a drawing of a human hand noting the metacarpal phalangeal joint (MCPJ) under study.
Iox1, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/iox1/product/Merck & Co
Average 90 stars, based on 1 article reviews
iox1 - by Bioz Stars, 2026-04
90/100 stars
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5-carboxy-8-hydroxyquinoline (iox1)  (Mimetics)
90
Mimetics 5-carboxy-8-hydroxyquinoline (iox1)
Chemical structures of the cationic (Gd(DTPA)Lys2 (Gd4+) & CA4+) and anionic (Gadopentetic acid (Gd2−) & <t>Ioxaglate</t> <t>(Iox1−))</t> MRI and CT contrasts agents, respectively, overlaid a drawing of a human hand noting the metacarpal phalangeal joint (MCPJ) under study.
5 Carboxy 8 Hydroxyquinoline (Iox1), supplied by Mimetics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/5-carboxy-8-hydroxyquinoline (iox1)/product/Mimetics
Average 90 stars, based on 1 article reviews
5-carboxy-8-hydroxyquinoline (iox1) - by Bioz Stars, 2026-04
90/100 stars
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Image Search Results


Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in H9C2 cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.

Journal: Frontiers in Immunology

Article Title: Characterization of the m 6 A regulators’ landscape highlights the clinical significance of acute myocardial infarction

doi: 10.3389/fimmu.2024.1308978

Figure Lengend Snippet: Therapeutic targeting of ALKBH5 attenuates H/R-induced apoptosis and ROS in H9C2 cells. (A) Representative immunofluorescent images of ALKBH5 in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (B) Quantification of ALKBH5 expression in the above H9C2 cells. (C) Representative images of TUNEL staining in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (D) Quantification of TUNEL-positive cell percentage in the above cells. ** p < 0.01; *** p < 0.001; **** p < 0.0001. (E) Representative photographs of DCFH-DA-stained ROS in H9C2 cells with normoxia, hypoxia, hypoxia + ALKBH5 inhibitor IOX1, or hypoxia + si-ALKBH5. Scale bar, 20 μm. (F) Quantification of intracellular ROS levels in the above H9C2 cells. *** p < 0.001; **** p < 0.0001.

Article Snippet: To inhibit ALKBH5 expression, H9C2 cells were pretreated with 50 μM of the ALKBH5 inhibitor IOX1 (Selleck, Shanghai, China) for 2 h ( ) or transfected with siRNAs against ALKBH5 (si-ALKBH5) (GenePharma, Shanghai, China) for 24 h via Lipofectamine RNAiMAX (Invitrogen, CA, USA).

Techniques: Expressing, TUNEL Assay, Staining

Chemical structures of the cationic (Gd(DTPA)Lys2 (Gd4+) & CA4+) and anionic (Gadopentetic acid (Gd2−) & Ioxaglate (Iox1−)) MRI and CT contrasts agents, respectively, overlaid a drawing of a human hand noting the metacarpal phalangeal joint (MCPJ) under study.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Article Title: dGEMRIC and CECT Comparison of Cationic and Anionic Contrast Agents in Cadaveric Human Metacarpal Cartilage

doi: 10.1002/jor.24511

Figure Lengend Snippet: Chemical structures of the cationic (Gd(DTPA)Lys2 (Gd4+) & CA4+) and anionic (Gadopentetic acid (Gd2−) & Ioxaglate (Iox1−)) MRI and CT contrasts agents, respectively, overlaid a drawing of a human hand noting the metacarpal phalangeal joint (MCPJ) under study.

Article Snippet: 31 Ioxaglate (Iox1−) at 105 mM (MW 1291 g/mol; 80 mgI/mL) was prepared by diluting Hexabrix320 (Mallinckrodt, St. Louis, MO) with deionized water.

Techniques:

Diffusion uptake MRI and CT plots for cationic Gd(DTPA)Lys2 (Gd4+) and CA4+, as well as anionic Gadopentetic Acid (Gd2−) and Ioxaglate, Iox1− contrast agents into ex vivo human metacarpal samples..

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Article Title: dGEMRIC and CECT Comparison of Cationic and Anionic Contrast Agents in Cadaveric Human Metacarpal Cartilage

doi: 10.1002/jor.24511

Figure Lengend Snippet: Diffusion uptake MRI and CT plots for cationic Gd(DTPA)Lys2 (Gd4+) and CA4+, as well as anionic Gadopentetic Acid (Gd2−) and Ioxaglate, Iox1− contrast agents into ex vivo human metacarpal samples..

Article Snippet: 31 Ioxaglate (Iox1−) at 105 mM (MW 1291 g/mol; 80 mgI/mL) was prepared by diluting Hexabrix320 (Mallinckrodt, St. Louis, MO) with deionized water.

Techniques: Diffusion-based Assay, Ex Vivo

a) Contrast agent uptake versus GAG content for MRI and CT imaging using cationic (Gd4+ & CA4+) and anionic (Gd2− & Iox1−) contrast agents (n=12). b) Contrast agent uptake versus indentation equilibrium modulus (E, MPa) for MRI and CT imaging using cationic (Gd4+ & CA4+) and anionic (Gd2− & Iox1−) contrast agents.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Article Title: dGEMRIC and CECT Comparison of Cationic and Anionic Contrast Agents in Cadaveric Human Metacarpal Cartilage

doi: 10.1002/jor.24511

Figure Lengend Snippet: a) Contrast agent uptake versus GAG content for MRI and CT imaging using cationic (Gd4+ & CA4+) and anionic (Gd2− & Iox1−) contrast agents (n=12). b) Contrast agent uptake versus indentation equilibrium modulus (E, MPa) for MRI and CT imaging using cationic (Gd4+ & CA4+) and anionic (Gd2− & Iox1−) contrast agents.

Article Snippet: 31 Ioxaglate (Iox1−) at 105 mM (MW 1291 g/mol; 80 mgI/mL) was prepared by diluting Hexabrix320 (Mallinckrodt, St. Louis, MO) with deionized water.

Techniques: Imaging

Contrast agent diffusion parameters (α, τ, 3*τ) and correlations between indentation equilibrium modulus, cartilage percent contrast agent uptake, Safranin-o histological staining red pixel density and GAG content.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Article Title: dGEMRIC and CECT Comparison of Cationic and Anionic Contrast Agents in Cadaveric Human Metacarpal Cartilage

doi: 10.1002/jor.24511

Figure Lengend Snippet: Contrast agent diffusion parameters (α, τ, 3*τ) and correlations between indentation equilibrium modulus, cartilage percent contrast agent uptake, Safranin-o histological staining red pixel density and GAG content.

Article Snippet: 31 Ioxaglate (Iox1−) at 105 mM (MW 1291 g/mol; 80 mgI/mL) was prepared by diluting Hexabrix320 (Mallinckrodt, St. Louis, MO) with deionized water.

Techniques: Diffusion-based Assay, Staining