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Image Search Results
Journal: Frontiers in Chemistry
Article Title: Isopeptide bond formation mediated by δ-selenolysine for chemical ubiquitination
doi: 10.3389/fchem.2023.1307254
Figure Lengend Snippet: Synthesis of δ-selenolysine derivatives L-9 and D-9 . Reagents and conditions: (a) i. NaHCO 3 /CuSO 4 ·5H 2 O, then Boc 2 O, ii. 8-quinolinol, iii. Ac 2 O/NaOH/1,4-dioxane:H 2 O = 1:1; (b) K 2 CO 3 /MeI/DMF; (c) MsCl/DIEA/DCM; (d) KSeCN/MeCN/60°C; (e) NaBH 4 /95% EtOH/THF/0°C; (f) i. TFA/DCM, ii. NaBH 4 /EtOH then 37% aq. HCHO, iii. Boc 2 O/K 2 CO 3 /water/1.4-dioxane, iv. NaOH/aq. THF; (g) L-aminoacylase (or D - aminoacylase)/0.2 M phosphate buffer pH 8.0/37°C; (h) Fmoc-OSu/THF.
Article Snippet:
Techniques: