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dmso dissolved az628 solution  (MedChemExpress)
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MedChemExpress dmso dissolved az628 solution
Effect of <t>AZ628</t> on human breast cancer cell line MCF7. ( A , B ) The proliferation of human breast cancer cell line MCF7 was significantly inhibited by AZ628 treatment. The results from the cell count assay ( A ) and the MTT assay ( B ) are shown. Data represented the mean ± SEM from five independent experiments, t -test, ** p < 0.01. Some SEM values in the drug-treated experimental group that are too small to be shown are specified here: ( A ) 24 h. 0.021; 48 h, 0.013; 72 h, 0.001; 96 h, 0.001; ( B ) 24 h. 0.035; 48 h, 0.038; 72 h, 0.047; 96 h, 0.094. ( C , D ) The protein expression of METTL3 in the MCF7 cell line was not significantly affected by drug treatment, t -test, none significance (ns). The summary of Western blot grey values as the mean ± SEM from three independent experiments ( C ) and the representative Western blot result ( D ) are shown. ( E ) The RNA m6A modification level in the MCF7 cell line was significantly decreased after AZ628 treatment. Data represented the mean ± SEM from five independent experiments, t -test, * p < 0.05. ( F , G ) Representative images of treated and control cells observed under an inverted 10× microscopy.
Dmso Dissolved Az628 Solution, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of AZ628 on human breast cancer cell line MCF7. ( A , B ) The proliferation of human breast cancer cell line MCF7 was significantly inhibited by AZ628 treatment. The results from the cell count assay ( A ) and the MTT assay ( B ) are shown. Data represented the mean ± SEM from five independent experiments, t -test, ** p < 0.01. Some SEM values in the drug-treated experimental group that are too small to be shown are specified here: ( A ) 24 h. 0.021; 48 h, 0.013; 72 h, 0.001; 96 h, 0.001; ( B ) 24 h. 0.035; 48 h, 0.038; 72 h, 0.047; 96 h, 0.094. ( C , D ) The protein expression of METTL3 in the MCF7 cell line was not significantly affected by drug treatment, t -test, none significance (ns). The summary of Western blot grey values as the mean ± SEM from three independent experiments ( C ) and the representative Western blot result ( D ) are shown. ( E ) The RNA m6A modification level in the MCF7 cell line was significantly decreased after AZ628 treatment. Data represented the mean ± SEM from five independent experiments, t -test, * p < 0.05. ( F , G ) Representative images of treated and control cells observed under an inverted 10× microscopy.

Journal: Genes

Article Title: Integrative Transcriptomic Analysis Identify Potential m6A Pathway-Related Drugs That Inhibit Cancer Cell Proliferation

doi: 10.3390/genes13112011

Figure Lengend Snippet: Effect of AZ628 on human breast cancer cell line MCF7. ( A , B ) The proliferation of human breast cancer cell line MCF7 was significantly inhibited by AZ628 treatment. The results from the cell count assay ( A ) and the MTT assay ( B ) are shown. Data represented the mean ± SEM from five independent experiments, t -test, ** p < 0.01. Some SEM values in the drug-treated experimental group that are too small to be shown are specified here: ( A ) 24 h. 0.021; 48 h, 0.013; 72 h, 0.001; 96 h, 0.001; ( B ) 24 h. 0.035; 48 h, 0.038; 72 h, 0.047; 96 h, 0.094. ( C , D ) The protein expression of METTL3 in the MCF7 cell line was not significantly affected by drug treatment, t -test, none significance (ns). The summary of Western blot grey values as the mean ± SEM from three independent experiments ( C ) and the representative Western blot result ( D ) are shown. ( E ) The RNA m6A modification level in the MCF7 cell line was significantly decreased after AZ628 treatment. Data represented the mean ± SEM from five independent experiments, t -test, * p < 0.05. ( F , G ) Representative images of treated and control cells observed under an inverted 10× microscopy.

Article Snippet: The A375 cells were divided into two groups: the control group was treated with the dimethyl sulfoxide (DMSO) solvent (1.11 μmol, Solarbio, Beijing, China) for 24 h, and the experimental group was treated with the DMSO-dissolved R-428 solution (1.11 μmol, MedChemExpress, Monmouth Junction, NJ, USA) for 24 h. The MCF7 cells were also divided into two groups: the control group was treated with the DMSO solvent (1.11 μmol, Solarbio, Beijing, China) for 24 h and the experimental group was treated with the DMSO-dissolved AZ628 solution (1.11 μmol, MedChemExpress, Monmouth Junction, NJ, USA) for 6 h. After treatment, single-cell suspensions were digested with trypsin (Gibco, Carlsbad, CA, USA) every 24 h, and trypan blue (Beyotime, Shanghai, China) was added to exclude dead cells, and cells were subsequently counted in counting plates.

Techniques: Cell Characterization, MTT Assay, Expressing, Western Blot, Modification, Control, Microscopy