ai32 females Search Results


ai32 female  (Jackson Laboratory)
90
Jackson Laboratory ai32 female
Ai32 Female, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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chr2 reporter females  (Jackson Laboratory)
90
Jackson Laboratory chr2 reporter females
( A ) Position-dependent CA1 PYR illumination indirectly activates local INTs. ( B ) PYR activation increases firing rates of INT on the illuminated shank. ( C ) PYR activation does not generate artificial fields in local INTs. ( D ) Precession prevalence during Control trials in spatially amplified INTs. ( E ) Spatially amplified INTs do not precess during Light trials. Here and in L , ns: p>0.0975, binomial test. ( F ) Local INT spike frequency relative to LFP is not higher during Light compared with Control trials. ( G ) In PPC of <t>CaMKII::ChR2</t> mice, focal closed-loop illumination activates PPC PYRs. ( H ) Illumination activates local PYRs. ( I ) Activation induces artificial fields in PPC PYRs. ( J ) PPC PYRs with artificial fields do not exhibit synthetic precession. ( K ) Precession prevalence during Control trials in spatially amplified PPC PYRs. ( L ) PPC PYR activation does not affect precession prevalence in spatially amplified PYRs. ( M ) PPC PYR spike frequency relative to LFP is not increased during Light trials. ( N ) Synthetic precession occurs in light-activated CA1 PYRs, but not in indirectly-activated CA1 INTs or in light-activated PPC PYRs. ns/***: p>0.05/p<0.001, binomial test. Lined ns/*/**/***: p>0.05/p<0.05/p<0.01/p<0.001, G-test.
Chr2 Reporter Females, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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chr2 reporter females - by Bioz Stars, 2026-03
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l7cre-2 x ai32 strain mice  (Jackson Laboratory)
90
Jackson Laboratory l7cre-2 x ai32 strain mice
a Effect of load and motor cortical perturbation on biceps and triceps EMG in a single session. Each contour corresponds to the average step-locked EMG in one of four load and optogenetic perturbation conditions. The angle represents the phase of the step cycle, and the radius of the EMG magnitude at the corresponding step phase. Bold = load, Color = optogenetic perturbation. EMG was normalized in each session based on the distribution of within-step peaks (see Methods). b Effect of load and cerebellar perturbation on biceps and triceps EMG in a single session. c Regression coefficients estimating the effects of load, optogenetic perturbation, the interaction between load and optogenetic perturbation, and step frequency on biceps and triceps EMG (motor cortical perturbation in VGAT-ChR2-EYFP animals: n = 4 mice, n = 18 sessions; cerebellar perturbation in <t>L7Cre-2</t> x <t>Ai32</t> animals: n = 3 mice, n = 16 sessions). Each point corresponds to a single experimental session; lines denote 95% confidence intervals. Figure 2a, b adapted from Thompson, E. (2020). Mouse brain above & side. Zenodo. 10.5281/zenodo.3925987. https://creativecommons.org/licenses/by/4.0/ .
L7cre 2 X Ai32 Strain Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


( A ) Position-dependent CA1 PYR illumination indirectly activates local INTs. ( B ) PYR activation increases firing rates of INT on the illuminated shank. ( C ) PYR activation does not generate artificial fields in local INTs. ( D ) Precession prevalence during Control trials in spatially amplified INTs. ( E ) Spatially amplified INTs do not precess during Light trials. Here and in L , ns: p>0.0975, binomial test. ( F ) Local INT spike frequency relative to LFP is not higher during Light compared with Control trials. ( G ) In PPC of CaMKII::ChR2 mice, focal closed-loop illumination activates PPC PYRs. ( H ) Illumination activates local PYRs. ( I ) Activation induces artificial fields in PPC PYRs. ( J ) PPC PYRs with artificial fields do not exhibit synthetic precession. ( K ) Precession prevalence during Control trials in spatially amplified PPC PYRs. ( L ) PPC PYR activation does not affect precession prevalence in spatially amplified PYRs. ( M ) PPC PYR spike frequency relative to LFP is not increased during Light trials. ( N ) Synthetic precession occurs in light-activated CA1 PYRs, but not in indirectly-activated CA1 INTs or in light-activated PPC PYRs. ns/***: p>0.05/p<0.001, binomial test. Lined ns/*/**/***: p>0.05/p<0.05/p<0.01/p<0.001, G-test.

Journal: bioRxiv

Article Title: Local activation of CA1 pyramidal cells induces theta phase precession

doi: 10.1101/2023.08.19.553985

Figure Lengend Snippet: ( A ) Position-dependent CA1 PYR illumination indirectly activates local INTs. ( B ) PYR activation increases firing rates of INT on the illuminated shank. ( C ) PYR activation does not generate artificial fields in local INTs. ( D ) Precession prevalence during Control trials in spatially amplified INTs. ( E ) Spatially amplified INTs do not precess during Light trials. Here and in L , ns: p>0.0975, binomial test. ( F ) Local INT spike frequency relative to LFP is not higher during Light compared with Control trials. ( G ) In PPC of CaMKII::ChR2 mice, focal closed-loop illumination activates PPC PYRs. ( H ) Illumination activates local PYRs. ( I ) Activation induces artificial fields in PPC PYRs. ( J ) PPC PYRs with artificial fields do not exhibit synthetic precession. ( K ) Precession prevalence during Control trials in spatially amplified PPC PYRs. ( L ) PPC PYR activation does not affect precession prevalence in spatially amplified PYRs. ( M ) PPC PYR spike frequency relative to LFP is not increased during Light trials. ( N ) Synthetic precession occurs in light-activated CA1 PYRs, but not in indirectly-activated CA1 INTs or in light-activated PPC PYRs. ns/***: p>0.05/p<0.001, binomial test. Lined ns/*/**/***: p>0.05/p<0.05/p<0.01/p<0.001, G-test.

Article Snippet: Three mice were double transgenics, offspring of CaMKII-Cre driver males (JAX #005359, The Jackson Labs) and ChR2 reporter females (Ai32; JAX #012569).

Techniques: Activation Assay, Amplification

a Effect of load and motor cortical perturbation on biceps and triceps EMG in a single session. Each contour corresponds to the average step-locked EMG in one of four load and optogenetic perturbation conditions. The angle represents the phase of the step cycle, and the radius of the EMG magnitude at the corresponding step phase. Bold = load, Color = optogenetic perturbation. EMG was normalized in each session based on the distribution of within-step peaks (see Methods). b Effect of load and cerebellar perturbation on biceps and triceps EMG in a single session. c Regression coefficients estimating the effects of load, optogenetic perturbation, the interaction between load and optogenetic perturbation, and step frequency on biceps and triceps EMG (motor cortical perturbation in VGAT-ChR2-EYFP animals: n = 4 mice, n = 18 sessions; cerebellar perturbation in L7Cre-2 x Ai32 animals: n = 3 mice, n = 16 sessions). Each point corresponds to a single experimental session; lines denote 95% confidence intervals. Figure 2a, b adapted from Thompson, E. (2020). Mouse brain above & side. Zenodo. 10.5281/zenodo.3925987. https://creativecommons.org/licenses/by/4.0/ .

Journal: Nature Communications

Article Title: An output-null signature of inertial load in motor cortex

doi: 10.1038/s41467-024-51750-7

Figure Lengend Snippet: a Effect of load and motor cortical perturbation on biceps and triceps EMG in a single session. Each contour corresponds to the average step-locked EMG in one of four load and optogenetic perturbation conditions. The angle represents the phase of the step cycle, and the radius of the EMG magnitude at the corresponding step phase. Bold = load, Color = optogenetic perturbation. EMG was normalized in each session based on the distribution of within-step peaks (see Methods). b Effect of load and cerebellar perturbation on biceps and triceps EMG in a single session. c Regression coefficients estimating the effects of load, optogenetic perturbation, the interaction between load and optogenetic perturbation, and step frequency on biceps and triceps EMG (motor cortical perturbation in VGAT-ChR2-EYFP animals: n = 4 mice, n = 18 sessions; cerebellar perturbation in L7Cre-2 x Ai32 animals: n = 3 mice, n = 16 sessions). Each point corresponds to a single experimental session; lines denote 95% confidence intervals. Figure 2a, b adapted from Thompson, E. (2020). Mouse brain above & side. Zenodo. 10.5281/zenodo.3925987. https://creativecommons.org/licenses/by/4.0/ .

Article Snippet: A total of 12 adult mice were used for experiments, including four (male) VGAT-ChR2-EYFP line-8 strain mice (Jackson Laboratory; JAX stock #014548) and eight (six male and two female) L7Cre-2 x Ai32 strain mice (Jackson Laboratory; JAX stock #004146 and #024109).

Techniques:

a Left: mice ( n = 2, L7Cre-2 x Ai32) were chronically implanted with silicon probes in the motor cortex and an optical fiber over the contralateral cerebellar cortex for stimulation of Purkinje cells. Right: raw data showing seven neurons recorded from the motor cortex during locomotion. b Firing rates and spike rasters for six motor cortical neurons recorded across sessions and mice showing different responses to load and cerebellar perturbation in the adaptive locomotion task. Bold = Load, Color = Purkinje cell stimulation. c Effect of load and cerebellar perturbation on motor cortical neurons ( n = 710). Each row corresponds to a single neuron, and displays the difference in z-scored firing rate between load on and off conditions (left) and between Purkinje cell stimulation on and off (right). Neurons are grouped based on the detection of an effect of load (black bar), stimulation (light blue bar), both (dark blue bar), or neither (remaining neurons). d Mean firing rates for all neurons in load on and off conditions (left) and Purkinje cell stimulation on and off (right). Color code reflects the detection of effects of load, stimulation, or both, as in ( c ). Bars indicate 95% confidence intervals for the mean. Figure 3a adapted from Tyler, E., & Kravitz, L. (2020). walking mouse. Zenodo. 10.5281/zenodo.3925915. https://creativecommons.org/licenses/by/4.0/ . Figure 3a adapted from Thompson, E. (2020). Mouse brain above & side. Zenodo. 10.5281/zenodo.3925987. https://creativecommons.org/licenses/by/4.0/ .

Journal: Nature Communications

Article Title: An output-null signature of inertial load in motor cortex

doi: 10.1038/s41467-024-51750-7

Figure Lengend Snippet: a Left: mice ( n = 2, L7Cre-2 x Ai32) were chronically implanted with silicon probes in the motor cortex and an optical fiber over the contralateral cerebellar cortex for stimulation of Purkinje cells. Right: raw data showing seven neurons recorded from the motor cortex during locomotion. b Firing rates and spike rasters for six motor cortical neurons recorded across sessions and mice showing different responses to load and cerebellar perturbation in the adaptive locomotion task. Bold = Load, Color = Purkinje cell stimulation. c Effect of load and cerebellar perturbation on motor cortical neurons ( n = 710). Each row corresponds to a single neuron, and displays the difference in z-scored firing rate between load on and off conditions (left) and between Purkinje cell stimulation on and off (right). Neurons are grouped based on the detection of an effect of load (black bar), stimulation (light blue bar), both (dark blue bar), or neither (remaining neurons). d Mean firing rates for all neurons in load on and off conditions (left) and Purkinje cell stimulation on and off (right). Color code reflects the detection of effects of load, stimulation, or both, as in ( c ). Bars indicate 95% confidence intervals for the mean. Figure 3a adapted from Tyler, E., & Kravitz, L. (2020). walking mouse. Zenodo. 10.5281/zenodo.3925915. https://creativecommons.org/licenses/by/4.0/ . Figure 3a adapted from Thompson, E. (2020). Mouse brain above & side. Zenodo. 10.5281/zenodo.3925987. https://creativecommons.org/licenses/by/4.0/ .

Article Snippet: A total of 12 adult mice were used for experiments, including four (male) VGAT-ChR2-EYFP line-8 strain mice (Jackson Laboratory; JAX stock #014548) and eight (six male and two female) L7Cre-2 x Ai32 strain mice (Jackson Laboratory; JAX stock #004146 and #024109).

Techniques: Cell Stimulation

a Left: mice ( n = 6, L7Cre-2 x Ai32) were chronically implanted with fine wire electrodes or Myomatrix electrode arrays in the biceps brachii and triceps brachii muscles and an optical fiber over the ipsilateral cerebellar cortex for stimulation of Purkinje cells. Right: raw motor unit data from the right and left triceps during locomotion recorded from an implanted Myomatrix array. b Firing rates and spike rasters for six spinally-innervated motor units in the adaptive locomotion task. Units 1 and 2 were recorded from the biceps ipsilateral to the load, and units 3–6 from the ipsilateral triceps. Bold = Load, Color = optogenetic perturbation. c Effect of load and cerebellar perturbation on motor units ( n = 108). Each row corresponds to a single motor unit, and displays the difference in z-scored firing rate between load on and off conditions (left) and between Purkinje cell stimulation on and off (right). Units are grouped based on the detection of an effect of load (black bar), stimulation (light blue bar), both (dark blue bar), or neither (remaining neurons). d Mean firing rates for all motor units in load on and off conditions (left) and Purkinje cell stimulation on and off (right). Color code reflects the detection of effects of load, stimulation, or both, as in ( c ). Bars indicate 95% confidence intervals for the mean. Figure 5a adapted from Tyler, E., & Kravitz, L. (2020). walking mouse. Zenodo. 10.5281/zenodo.3925915. https://creativecommons.org/licenses/by/4.0/ . Figure 5a adapted from Thompson, E. (2020). Mouse brain above & side. Zenodo. 10.5281/zenodo.3925987. https://creativecommons.org/licenses/by/4.0/ .

Journal: Nature Communications

Article Title: An output-null signature of inertial load in motor cortex

doi: 10.1038/s41467-024-51750-7

Figure Lengend Snippet: a Left: mice ( n = 6, L7Cre-2 x Ai32) were chronically implanted with fine wire electrodes or Myomatrix electrode arrays in the biceps brachii and triceps brachii muscles and an optical fiber over the ipsilateral cerebellar cortex for stimulation of Purkinje cells. Right: raw motor unit data from the right and left triceps during locomotion recorded from an implanted Myomatrix array. b Firing rates and spike rasters for six spinally-innervated motor units in the adaptive locomotion task. Units 1 and 2 were recorded from the biceps ipsilateral to the load, and units 3–6 from the ipsilateral triceps. Bold = Load, Color = optogenetic perturbation. c Effect of load and cerebellar perturbation on motor units ( n = 108). Each row corresponds to a single motor unit, and displays the difference in z-scored firing rate between load on and off conditions (left) and between Purkinje cell stimulation on and off (right). Units are grouped based on the detection of an effect of load (black bar), stimulation (light blue bar), both (dark blue bar), or neither (remaining neurons). d Mean firing rates for all motor units in load on and off conditions (left) and Purkinje cell stimulation on and off (right). Color code reflects the detection of effects of load, stimulation, or both, as in ( c ). Bars indicate 95% confidence intervals for the mean. Figure 5a adapted from Tyler, E., & Kravitz, L. (2020). walking mouse. Zenodo. 10.5281/zenodo.3925915. https://creativecommons.org/licenses/by/4.0/ . Figure 5a adapted from Thompson, E. (2020). Mouse brain above & side. Zenodo. 10.5281/zenodo.3925987. https://creativecommons.org/licenses/by/4.0/ .

Article Snippet: A total of 12 adult mice were used for experiments, including four (male) VGAT-ChR2-EYFP line-8 strain mice (Jackson Laboratory; JAX stock #014548) and eight (six male and two female) L7Cre-2 x Ai32 strain mice (Jackson Laboratory; JAX stock #004146 and #024109).

Techniques: Muscles, Cell Stimulation