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All (9)
New England Biolabs
Selleck Chemicals
Eisai
BOC Sciences
MedChemExpress
Cayman
Aladdin Scientific
Biosynth
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About 18 products / 1,964 snippets / 33 images

94 / 100
Bioz vStars
E6446
Aladdin Scientific  
Catalog#: E412503-5MG
Description
"InformationE6446 E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro.TargetsTLR7 ; TLR9 ; DNA-TLR9"
94 / 100
Bioz Stars
NEBNext Multiplex Oligos for Illumina
New England Biolabs  
Catalog#: E6446
Techniques
 
Article Snippets
"PrePrint: of total RNA per sample was used as input for the NEBNext Ultra II RNA Library Prep kit with Sample Purification Beads (E7775S), in combination with the NEBNext Poly(A) mRNA Magnetic Isolation Module (New England BioLabs E7490L). Libraries were indexed with NEBNext Multiplex Oligos for Illumina (Dual Index Primers Set 1) (New England BioLabs E7600S). Completed libraries underwent quality assessment"  (see more)
94 / 100
Bioz Stars
NEBNext Multiplex Oligos for Illumina
New England Biolabs  
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Catalog#: E6446
Techniques
 
Article Snippets
"PrePrint: of total RNA per sample was used as input for the NEBNext Ultra II RNA Library Prep kit with Sample Purification Beads (E7775S), in combination with the NEBNext Poly(A) mRNA Magnetic Isolation Module (New England BioLabs E7490L). Libraries were indexed with NEBNext Multiplex Oligos for Illumina (Dual Index Primers Set 1) (New England BioLabs E7600S). Completed libraries underwent quality assessment"  (see more)
93 / 100
Bioz Stars
E6446
MedChemExpress  
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Catalog#: HY-12756A
Techniques
Cell Culture, Modification, Transfection, Plasmid Preparation (see more)
Article Snippets
".. MedChemExpress, USA) (CT-OV), the control group treated with TLR9 inhibitor E6446 dihydrochloride (10 μM, dissolved in 14.55 mM DMSO; Catalog: HY-12756A, MedChemExpress, USA) (CTSI), the diabetes group (DM), the diabetes .."  (see more)
29+  more images
Selectivity of <t>E6446</t> The expression level of cytokine messenger ribonucleic acid in cardiomyocytes with increasing concentrations of E6446, (6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole) (n = 3). Cardiomyocytes were treated with 0 to 10 μmol/l of E6446 for 1 h, followed by (A) 5 μmol/l ODN1668, (B) 1 μg/ml of lipopolysaccharide (LPS), or (C) 2 mmol/l of loxoribine for 6 h. Control groups were treated with vehicle. Data were normalized to the content of Gapdh messenger ribonucleic acid. Values are mean ± SE. Bars in graphs indicate p < 0.05. *p < 0.05 versus both control groups.
EXP
CON
Toll-like receptor 9 (TLR9) is responsible for LG2055 DNA-induced IFN-α production: ( A ) PBMCs were pretreated with 0.5 μM <t>E6446,</t> a TLR9 inhibitor, for 1 h and then treated with DNA/DOTAP for 24 h. ( B ) PBMCs were treated with LG2055 and/or DOTAP for 24 h. ( A , B ) IFN-α concentration in the supernatant was measured using ELISA. ( C ) PBMCs were pretreated with 0.5 μM E6446 for 1 h and then treated with LG2055 for 24 h. CD86 and HLA-DR expression on pDCs was evaluated via flow cytometry. ( A – C ) Each experiment was performed in triplicate ( n = 3). Data are expressed as mean ± standard deviation. Test substances were added at a concentration of 10 μg/mL (LG2055) or 1 μg/mL (DNA). ( A , B ) *** p < 0.001 according to Student’s t -test. ( C ) * p < 0.05 and ** p < 0.01 according to one-way ANOVA and Tukey–Kramer post hoc test.
CO-A
ELISA
EXP
FC
SD
The protocol 1 aims to examine the preventive effect of a toll‐like receptor 9 (TLR9) inhibitor, <t>E6446</t> on pulmonary hypertension (PH) in monocrotaline (MCT)‐exposed rats. The protocol 2 aims to examine the short‐term effect of TLR9 inhibition on inflammatory responses in the established PH in MCT‐exposed rats. The protocol 3 aims to examine the therapeutic effect of E6446 on the established PH in MCT‐exposed rats. CLQ: chloroquine; MCT: monocrotaline; and TLR9: toll‐like receptor 9.
Products under development for severe malaria, or as artemisinin monotherapy
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90 / 100
Bioz Stars
E6446 dihydrochloride
BOC Sciences  
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Catalog#: B0084-473903
Techniques
 
Article Snippets
" l -cysteine (NAC) was obtained from Alexis (distributed by Axxora, Germany), dissolved in unsupplemented MEM and adjusted to pH 7.4 with NaOH. Eritoran (E5564) was purchased from BOC Sciences (USA). "  (see more)
91 / 100
Bioz Stars
E6446
Eisai  
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Techniques
 
Article Snippets
"E6446 (Eisai, Inc., Andover, Massachusetts) was dissolved in dimethyl sulfoxide (final 0.04% v/v) for experiments."  (see more)
EXP
CON
80 / 100
Bioz Stars
E6446
Cayman  
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Techniques
 
Article Snippets
"E6446 (Cayman Chemical 37296) was dissolved in 1:4 DMSO:PEG300, diluted in PBS and administered at 10 mg/kg via intraperitoneal injection."  (see more)
92 / 100
Bioz Stars
E6446
Selleck Chemicals  
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Techniques
 
Article Snippets
".. [Selleck, S2638], 10 nM nedisertib [Selleck, S8586], 5 nM H151 [Cayman, CAY-25857], 2 nM E6446 [Selleck, S6719] and 10 μM AC-YVAD-fmk [Merck, 178603-78-6]) for 24 hours."  (see more)
85 / 100
Bioz Stars
Compound E6446-02
Eisai  
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Techniques
 
Article Snippets
"The compound E6446-02 (Eisai) was dissolved in water, and its concentrations were adjusted so that the final dose in body weight (mg/kg) was given in 0.1 mL."  (see more)
80 / 100
Bioz Stars
TLR9 inhibitor E6446
Selleck Chemicals  
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Techniques
 
Article Snippets
"Blood samples were incubated with TLR9 inhibitor E6446 (Selleckchem.com, CatS0716) at three concentrations: 0.2, 2, and 20 μM for 60 minutes."  (see more)
85 / 100
Bioz Stars
E6446{6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole
Eisai  
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Techniques
 
Article Snippets
".. (Ann Arbor, MI) and E6446{6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole} was generously provided by Eisai Inc (Tokyo, Japan)."  (see more)
EXP
TNSF
90 / 100
Bioz Stars
E6446
BOC Sciences  
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Catalog#: 1219925-73-1
Techniques
 
Article Snippets
"Abstract: Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Pruri ..."  (see more)
93 / 100
Bioz vStars
e6446
Selleck Chemicals  
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Catalog#: S0716-2MG
Description
"E6446 is an inhibitor of Toll like receptor TLR 7 and 9 signaling E6446 works in a variety of human and mouse cell types and inhibits DNA TLR9 interaction in vitro"
93 / 100
Bioz vStars
E6446
Biosynth  
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Catalog#: VDC67525
94 / 100
Bioz vStars
E6446
Aladdin Scientific  
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Catalog#: E412503-5MG
Description
"InformationE6446 E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro.TargetsTLR7 ; TLR9 ; DNA-TLR9"
94 / 100
Bioz vStars
E6446 dihydrochloride
Aladdin Scientific  
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Catalog#: E413596-100MG
Description
"InformationE6446 dihydrochloride E6446 dihydrochloride is a specific Toll-like receptor 9 inhibitor.TargetsTLR9In vivoE6446 is orally bioavailable (20%) and has high volumes of distribution in mice (95.9 l/kg)."
93 / 100
Bioz Stars
E6446
MedChemExpress  
Catalog#: HY-12756A
Techniques
Cell Culture, Modification, Transfection, Plasmid Preparation (see more)
Article Snippets
".. MedChemExpress, USA) (CT-OV), the control group treated with TLR9 inhibitor E6446 dihydrochloride (10 μM, dissolved in 14.55 mM DMSO; Catalog: HY-12756A, MedChemExpress, USA) (CTSI), the diabetes group (DM), the diabetes .."  (see more)