40592-V08H80 Search Results


rbd mutants  (Sino Biological)
93
Sino Biological rbd mutants
UK ( a ) and South African (SA) <t>RBD</t> <t>mutants</t> ( b ) have differing effects upon antibody binding. RBD mutant antigens were generated and added to MULTICOV-AB to measure the immune response towards them in sera from vaccinated pre-second dose (light blue) (n=25), post-second dose (dark blue) (n=20) and infected (red) (n=35) individuals, compared to the wild-type (wt) RBD. A linear curve (y=x) is shown as a dashed grey-line to indicate identical response between wild-type and mutant. Kendall’s tau was calculated to measure ordinal association between the mutant and wild-type.
Rbd Mutants, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rbd mutants/product/Sino Biological
Average 93 stars, based on 1 article reviews
rbd mutants - by Bioz Stars, 2026-05
93/100 stars
  Buy from Supplier

Image Search Results


UK ( a ) and South African (SA) RBD mutants ( b ) have differing effects upon antibody binding. RBD mutant antigens were generated and added to MULTICOV-AB to measure the immune response towards them in sera from vaccinated pre-second dose (light blue) (n=25), post-second dose (dark blue) (n=20) and infected (red) (n=35) individuals, compared to the wild-type (wt) RBD. A linear curve (y=x) is shown as a dashed grey-line to indicate identical response between wild-type and mutant. Kendall’s tau was calculated to measure ordinal association between the mutant and wild-type.

Journal: medRxiv

Article Title: Immune response to SARS-CoV-2 variants of concern in vaccinated individuals

doi: 10.1101/2021.03.08.21252958

Figure Lengend Snippet: UK ( a ) and South African (SA) RBD mutants ( b ) have differing effects upon antibody binding. RBD mutant antigens were generated and added to MULTICOV-AB to measure the immune response towards them in sera from vaccinated pre-second dose (light blue) (n=25), post-second dose (dark blue) (n=20) and infected (red) (n=35) individuals, compared to the wild-type (wt) RBD. A linear curve (y=x) is shown as a dashed grey-line to indicate identical response between wild-type and mutant. Kendall’s tau was calculated to measure ordinal association between the mutant and wild-type.

Article Snippet: All RBD mutants except the Mink variant (#40592-V08H80, Sino Biological) were produced in-house.

Techniques: Binding Assay, Mutagenesis, Generated, Infection

When compared to wild-type (wt), RBD mutants for both the Mink ( a ) and LA ( b ) variants of concern resulted in similar response. RBD mutant antigens were generated (LA) or purchased (Mink) and added to MULTICOV-AB to measure the immune response towards them from vaccinated (N=45) and infected (N=35) sera, compared to the wild-type RBD. A linear curve (y=x) is shown as a dashed grey-line to indicate identical response between wild-type and mutant. Kendall’s tau was calculated to measure ordinal association between the mutant and wild-type.

Journal: medRxiv

Article Title: Immune response to SARS-CoV-2 variants of concern in vaccinated individuals

doi: 10.1101/2021.03.08.21252958

Figure Lengend Snippet: When compared to wild-type (wt), RBD mutants for both the Mink ( a ) and LA ( b ) variants of concern resulted in similar response. RBD mutant antigens were generated (LA) or purchased (Mink) and added to MULTICOV-AB to measure the immune response towards them from vaccinated (N=45) and infected (N=35) sera, compared to the wild-type RBD. A linear curve (y=x) is shown as a dashed grey-line to indicate identical response between wild-type and mutant. Kendall’s tau was calculated to measure ordinal association between the mutant and wild-type.

Article Snippet: All RBD mutants except the Mink variant (#40592-V08H80, Sino Biological) were produced in-house.

Techniques: Mutagenesis, Generated, Infection

To determine the effect variants of concern had upon neutralization potential, an ACE2 competition assay was developed. RBD mutants for all variants of concern included within this manuscript (UK ( a ), Mink ( b ), LA ( c )) were examined as well as the wild-type (wt) variant on sera from infected (red, N=35) and vaccinated (pre second vaccination (light blue, N=25), post second vaccination (dark blue, N=20)) individuals. Linear regression (y=x) was calculated for each panel, with the R 2 value shown. Linear regressions had the following equations for the different figure panels: ( a ) y = −0.026 + 0.820x ( b ) y = −0.036 + 0.840x ( c ) y = −0.03 + 0.835x

Journal: medRxiv

Article Title: Immune response to SARS-CoV-2 variants of concern in vaccinated individuals

doi: 10.1101/2021.03.08.21252958

Figure Lengend Snippet: To determine the effect variants of concern had upon neutralization potential, an ACE2 competition assay was developed. RBD mutants for all variants of concern included within this manuscript (UK ( a ), Mink ( b ), LA ( c )) were examined as well as the wild-type (wt) variant on sera from infected (red, N=35) and vaccinated (pre second vaccination (light blue, N=25), post second vaccination (dark blue, N=20)) individuals. Linear regression (y=x) was calculated for each panel, with the R 2 value shown. Linear regressions had the following equations for the different figure panels: ( a ) y = −0.026 + 0.820x ( b ) y = −0.036 + 0.840x ( c ) y = −0.03 + 0.835x

Article Snippet: All RBD mutants except the Mink variant (#40592-V08H80, Sino Biological) were produced in-house.

Techniques: Neutralization, Competitive Binding Assay, Variant Assay, Infection