wt-161 Search Results


wt161  (MedChemExpress)
93
MedChemExpress wt161
( A ) U2OS cells were subjected to various concentrations of (0–1.6 µM) <t>WT161</t> for 48 h and the acetyl-α-tubulin was examined. ( B ) U2OS cells were treated with various concentrations of WT161 for 48 h (left) or different days (right) and the cell growth was assessed using CCK-8 assay. ( C ) MG63 cells were treated with various concentrations of WT161 for 48 h (left) or different days (right) and the cell growth was accessed using CCK-8 assay. ( D ) MG63 cells were inoculated into six-well plates (1000 cells/well). Each well was treated with different concentrations of WT161 (0–6 µM) for two weeks. The cells were stained with 0.1% Crystal Violet dye overnight. n =3, ** P <0.01, *** P <0.001.
Wt161, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/wt-161/WT-161/pmc08150159-23-0-4
Average 93 stars, based on 1 article reviews
wt161 - by Bioz Stars, 2026-10
93/100 stars
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wt161  (MuseChem Chemicals)
N/A
WT161（Cat No.:R066903）is a potent, selective inhibitor of histone deacetylase 6 (HDAC6), an enzyme involved in regulating protein degradation, cell motility, and immune responses. By inhibiting HDAC6, WT161 disrupts the deacetylation of proteins such as tubulin
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wt161  (Selleck Chemicals)
93
Selleck Chemicals wt161

Wt161, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/wt-161/WT161/pmc08202734-107-0-2
Average 93 stars, based on 1 article reviews
wt161 - by Bioz Stars, 2026-10
93/100 stars
  Buy from Supplier
wt-161  (Acetylon Inc)
90
Acetylon Inc wt-161

Wt 161, supplied by Acetylon Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/wt-161/wt+161/us11059815-175-0-7
Average 90 stars, based on 1 article reviews
wt-161 - by Bioz Stars, 2026-10
90/100 stars
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wt161  (Aladdin Scientific Corporation)
N/A
InformationWT161 is a potent, selective, and bioavailableHDAC6inhibitor withIC50 valuesof 0.4 nM, 8.35 nM and 15.4 nM for HDAC6, HDAC1 and HDAC2, respectively; shown to have >100-fold selectivity over other HDACs. WT161 inducesapoptosis.TargetsHDAC6 (Cell-free assay); HDAC1
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wt-161  (BOC Sciences)
N/A
WT-161 is a potent and specific HDAC6 inhibitor (IC50= 0.40 nM). Consistent with WT-161 mediated hyperacetylation and inhibition of hsp90 chaperone function, treatment with WT-161 increased the intracellular levels of polyubiuitylated proteins in the cultured
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wt-161  (Biosynth Carbosynth)
N/A
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wt161  (Cayman Chemical)
N/A
WT161 is a potent inhibitor of HDAC6 with an IC value of 0 40 nM It is selective for HDAC6 over HDAC3 IC 51 61 nM and induces α tubulin acetylation an HDAC6 dependent process
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wt-161  (TargetMol)
N/A
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wt-161  (1PlusChem LLC)
N/A
WT-161
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Image Search Results


( A ) U2OS cells were subjected to various concentrations of (0–1.6 µM) WT161 for 48 h and the acetyl-α-tubulin was examined. ( B ) U2OS cells were treated with various concentrations of WT161 for 48 h (left) or different days (right) and the cell growth was assessed using CCK-8 assay. ( C ) MG63 cells were treated with various concentrations of WT161 for 48 h (left) or different days (right) and the cell growth was accessed using CCK-8 assay. ( D ) MG63 cells were inoculated into six-well plates (1000 cells/well). Each well was treated with different concentrations of WT161 (0–6 µM) for two weeks. The cells were stained with 0.1% Crystal Violet dye overnight. n =3, ** P <0.01, *** P <0.001.

Journal: Bioscience Reports

Article Title: HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

doi: 10.1042/BSR20203905

Figure Lengend Snippet: ( A ) U2OS cells were subjected to various concentrations of (0–1.6 µM) WT161 for 48 h and the acetyl-α-tubulin was examined. ( B ) U2OS cells were treated with various concentrations of WT161 for 48 h (left) or different days (right) and the cell growth was assessed using CCK-8 assay. ( C ) MG63 cells were treated with various concentrations of WT161 for 48 h (left) or different days (right) and the cell growth was accessed using CCK-8 assay. ( D ) MG63 cells were inoculated into six-well plates (1000 cells/well). Each well was treated with different concentrations of WT161 (0–6 µM) for two weeks. The cells were stained with 0.1% Crystal Violet dye overnight. n =3, ** P <0.01, *** P <0.001.

Article Snippet: WT161 was purchased from MedChemExpress (U.S.A.) and prepared in dimethyl sulfoxide (DMSO) (Sigma–Aldrich, St. Louis, MO, U.S.A.).

Techniques: CCK-8 Assay, Staining

( A ) U2OS cells were subjected to various concentrations of WT161 for 48 h. The cell apoptosis was assessed by flow cytometry. n =3, ** P <0.01. ( B ) MG63 cells were subjected to various concentrations of WT161 for 48 h. The cell apoptosis was assessed by flow cytometry. n =3, ** P <0.01. ( C ) The protein expression levels of PARP and cleaved PARP were tested in U2OS and MG63 cells treated with WT161 for 48 h using the Western blot analysis. n =3, ** P <0.01.

Journal: Bioscience Reports

Article Title: HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

doi: 10.1042/BSR20203905

Figure Lengend Snippet: ( A ) U2OS cells were subjected to various concentrations of WT161 for 48 h. The cell apoptosis was assessed by flow cytometry. n =3, ** P <0.01. ( B ) MG63 cells were subjected to various concentrations of WT161 for 48 h. The cell apoptosis was assessed by flow cytometry. n =3, ** P <0.01. ( C ) The protein expression levels of PARP and cleaved PARP were tested in U2OS and MG63 cells treated with WT161 for 48 h using the Western blot analysis. n =3, ** P <0.01.

Article Snippet: WT161 was purchased from MedChemExpress (U.S.A.) and prepared in dimethyl sulfoxide (DMSO) (Sigma–Aldrich, St. Louis, MO, U.S.A.).

Techniques: Flow Cytometry, Expressing, Western Blot

( A ) U2OS cells were treated with WT161 for 48 h and the protein expression levels of PTEN, P-Akt and Akt were tested using Western blot. n =3, ** P <0.01. ( B ) MG63 cells were treated with WT161 for 48 h and the protein expression levels of PTEN, P-Akt and Akt were tested using Western blot. n =3, ** P <0.01. ( C ) Silencing of PTEN reduces the apoptosis of osteosarcoma cells. U2OS and MG63 cells transfected with PTEN siRNA or negative control for 24 h were treated with WT161 for 48 h and the apoptotic cells were evaluated by flow cytometry.

Journal: Bioscience Reports

Article Title: HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

doi: 10.1042/BSR20203905

Figure Lengend Snippet: ( A ) U2OS cells were treated with WT161 for 48 h and the protein expression levels of PTEN, P-Akt and Akt were tested using Western blot. n =3, ** P <0.01. ( B ) MG63 cells were treated with WT161 for 48 h and the protein expression levels of PTEN, P-Akt and Akt were tested using Western blot. n =3, ** P <0.01. ( C ) Silencing of PTEN reduces the apoptosis of osteosarcoma cells. U2OS and MG63 cells transfected with PTEN siRNA or negative control for 24 h were treated with WT161 for 48 h and the apoptotic cells were evaluated by flow cytometry.

Article Snippet: WT161 was purchased from MedChemExpress (U.S.A.) and prepared in dimethyl sulfoxide (DMSO) (Sigma–Aldrich, St. Louis, MO, U.S.A.).

Techniques: Expressing, Western Blot, Transfection, Negative Control, Flow Cytometry

( A ) U2OS cells were subjected to 5-FU alone or in combined with WT161. The synergistic effect of various concentration ranges of WT161 and 5-FU were shown using CDI. ( B ) MG63 cells were subjected to 5-FU alone or in combination with WT161. The synergistic effect of various concentration ranges of WT161 and 5-FU were shown using CDI.

Journal: Bioscience Reports

Article Title: HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU

doi: 10.1042/BSR20203905

Figure Lengend Snippet: ( A ) U2OS cells were subjected to 5-FU alone or in combined with WT161. The synergistic effect of various concentration ranges of WT161 and 5-FU were shown using CDI. ( B ) MG63 cells were subjected to 5-FU alone or in combination with WT161. The synergistic effect of various concentration ranges of WT161 and 5-FU were shown using CDI.

Article Snippet: WT161 was purchased from MedChemExpress (U.S.A.) and prepared in dimethyl sulfoxide (DMSO) (Sigma–Aldrich, St. Louis, MO, U.S.A.).

Techniques: Concentration Assay

Journal: Cell Stem Cell

Article Title: Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids

doi: 10.1016/j.stem.2021.03.022

Figure Lengend Snippet:

Article Snippet: WT161 , Selleckchem , S8495.

Techniques: Activity Assay, Colorimetric Assay, Staining, Plasmid Preparation, Recombinant, Software, Cell Recovery