Journal: Psychopharmacology

Article Title: Functional profile of a novel modulator of serotonin, dopamine, and glutamate neurotransmission

doi: 10.1007/s00213-014-3704-1

Figure Lengend Snippet: Effect of chronic administration of ITI-007 on social behavior following repeated social defeat. Mice ( N = 8–12/treatment group) were subjected to exposure to an aggressive resident mouse in the social defeat/resident intruder paradigm. They were then dosed once daily for 28 days, with either vehicle (5 % DMSO/5 % Tween 20/15 % PEG400/75 % water, 6.7 ml/kg volume) or ITI-007 (1 mg/kg, ip.) in vehicle solution. On the day after the last drug or vehicle treatment, mice were placed in the open field in the presence of a resident mouse (enclosed in a smaller cage) and the animal’s behavior recorded by videotape for 150 s. Videotracking software was employed to calculate the time spent by each mouse in specified open-field quadrants, defined schematically in a . The total time (s) spent by each drug treatment group in the interaction zone ( b ) in proximity to the resident mouse or in the corner zones, at a distance from the resident mouse ( c ) was expressed as a mean (±SEM). * p < 0.05; ** p < 0.01 compared with control vehicle; NS not significantly different from drug-treated control

Article Snippet: On the day after the last drug or vehicle treatment, the mice were placed in an open field in the presence of a resident mouse (within a smaller cage) and the animal’s behavior recorded by videotape for 150 s. Videotracking software (Noldus, Netherlands) was used to calculate the total time each mouse spent in specified open-field quadrants, defined schematically in Fig. .

Techniques: Software, Control