Journal: Kidney International Reports

Article Title: Immunomodulatory Device Therapy in a Pediatric Patient With Acute Kidney Injury and Multiorgan Dysfunction

doi: 10.1016/j.ekir.2017.06.131

Figure Lengend Snippet: Extracorporeal blood circuit under standard continuous renal replacement therapy (CRRT) (solid lines) and after the integration of the selective cytopheretic device (SCD) into the circuit. The blood flow path in the SCD is in the extracapillary space along the outside surfaces of the hollow fibers. This flow path results in low shear force along the fibers, which allows for activated neutrophils and monocytes to selectively bind to the membrane. The low ionized calcium (iCa) environment promotes deactivation and release of the bound cells back to the systemic circulation. This process results in continuous leukocyte cell processing and immunomodulation of the excessive systemic inflammatory response state of acute kidney injury. , , , , , , , , The SCD is changed every 24 hours for up to 7 days of treatment, a treatment time found to be effective in previous clinical studies. *Side ports of SCD for elution sampling.

Article Snippet: CRRT was performed with the Prismafle CRRT machine (software v7.11, Baxter Healthcare, Deerfield, IL), using an HF-1000 filter with a blood pump flow of 150 ml/min, dialysis fluid rate of 3000 ml/h, and postfilter replacement fluid rate of 1100 ml/h (total prescribed clearance of 4729 ml/h per 1.73m 2 ).

Techniques: Shear, Membrane, Sampling