ttp22 Search Results


ttp22  (MedChemExpress)
91
MedChemExpress ttp22
Ttp22, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ttp22/product/MedChemExpress
Average 91 stars, based on 1 article reviews
ttp22 - by Bioz Stars, 2026-04
91/100 stars
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ttp22  (Tocris)
90
Tocris ttp22
( A ) IC261, CX-4945, and DMAT treatments (48 h) lead to downregulation of AT2 cell markers. <t>TTP22</t> and Emodin (also CK2 inhibitors) do not lead to the same phenotype, possibly due to differences in potency/target affinity. Expression levels relative to DMSO control. Three biological replicates (consisting of 2 technical replicates each) were analyzed per compound. ( B ) Casein Kinase inhibition by IC261, CX-4945, and DMAT (6 h) leads to reduced Axin2 relative expression. Treatment with TTP22 or Emodin does not significantly affect Axin2 levels. More than three biological replicates were analyzed. ( C ) CK inhibition reduced WNT/β-catenin-dependent transcription in HEK293T epithelial cells (SuperTOPFlash-based luciferase assay). ( B ) Mean values are displayed; error bars represent S.D.; p - values from one-way ANOVA, Tukey’s multiple comparisons test. ( C ) Mean values displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test; displayed p-values refer to comparisons with WNT3A-treated condition. Figure 4—source data 1. Normalized expression values of AT2 cell markers, CK inhibitors vs. DMSO control. Normalized Axin2 expression values, CK inhibitors vs. DMSO control and related statistics. Raw luciferase data. Normalized luciferase values and related statistics.
Ttp22, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ttp22/product/Tocris
Average 90 stars, based on 1 article reviews
ttp22 - by Bioz Stars, 2026-04
90/100 stars
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drug ttp22 tocris tocris  (Tocris)
88
Tocris drug ttp22 tocris tocris
Figure 4. Compounds promoting AT1 cell differentiation lead to concomitant loss of AT2 marker gene expression and WNT-dependent transcription. (A) IC261, CX-4945, and DMAT treatments (48 h) lead to downregulation of AT2 cell markers. <t>TTP22</t> and Emodin (also CK2 inhibitors) do not lead to the same phenotype, possibly due to differences in potency/target affinity. Expression levels relative to DMSO control. Three biological replicates (consisting of 2 technical replicates each) were analyzed per compound. (B) Casein Kinase inhibition by IC261, CX-4945, and DMAT (6 h) leads to reduced Axin2 relative expression. Treatment with TTP22 or Emodin does not significantly affect Axin2 levels. More than three biological replicates were analyzed. (C) CK inhibition reduced WNT/β-catenin-dependent transcription in HEK293T epithelial cells (SuperTOPFlash-based luciferase assay). (B) Mean values are displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test. (C) Mean values displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test; displayed p-values refer to comparisons with WNT3A- treated condition.
Drug Ttp22 Tocris Tocris, supplied by Tocris, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/drug ttp22 tocris tocris/product/Tocris
Average 88 stars, based on 1 article reviews
drug ttp22 tocris tocris - by Bioz Stars, 2026-04
88/100 stars
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ck2 inhibitor ttp 22  (Santa Cruz Biotechnology)
88
Santa Cruz Biotechnology ck2 inhibitor ttp 22
Figure 4. Compounds promoting AT1 cell differentiation lead to concomitant loss of AT2 marker gene expression and WNT-dependent transcription. (A) IC261, CX-4945, and DMAT treatments (48 h) lead to downregulation of AT2 cell markers. <t>TTP22</t> and Emodin (also CK2 inhibitors) do not lead to the same phenotype, possibly due to differences in potency/target affinity. Expression levels relative to DMSO control. Three biological replicates (consisting of 2 technical replicates each) were analyzed per compound. (B) Casein Kinase inhibition by IC261, CX-4945, and DMAT (6 h) leads to reduced Axin2 relative expression. Treatment with TTP22 or Emodin does not significantly affect Axin2 levels. More than three biological replicates were analyzed. (C) CK inhibition reduced WNT/β-catenin-dependent transcription in HEK293T epithelial cells (SuperTOPFlash-based luciferase assay). (B) Mean values are displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test. (C) Mean values displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test; displayed p-values refer to comparisons with WNT3A- treated condition.
Ck2 Inhibitor Ttp 22, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 88/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ck2 inhibitor ttp 22/product/Santa Cruz Biotechnology
Average 88 stars, based on 1 article reviews
ck2 inhibitor ttp 22 - by Bioz Stars, 2026-04
88/100 stars
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ttp 22  (TargetMol)
N/A
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ttp 22  (Aladdin Scientific Corporation)
N/A
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ttp 22  (Selleck Chemicals)
N/A
TTP22 is a casein kinase 2 (CK2) inhibitor with an IC50 value of 100 nM. It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM.
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ttp 22  (Cayman Chemical)
N/A
TTP 22
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ttp 22  (Biosynth Carbosynth)
N/A
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ttp 22  (BOC Sciences)
N/A
Potent and ATP-competitive casein kinase 2 (CK2) inhibitor (IC50 = 0.1 μM, Ki = 40 nM)
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Image Search Results


( A ) IC261, CX-4945, and DMAT treatments (48 h) lead to downregulation of AT2 cell markers. TTP22 and Emodin (also CK2 inhibitors) do not lead to the same phenotype, possibly due to differences in potency/target affinity. Expression levels relative to DMSO control. Three biological replicates (consisting of 2 technical replicates each) were analyzed per compound. ( B ) Casein Kinase inhibition by IC261, CX-4945, and DMAT (6 h) leads to reduced Axin2 relative expression. Treatment with TTP22 or Emodin does not significantly affect Axin2 levels. More than three biological replicates were analyzed. ( C ) CK inhibition reduced WNT/β-catenin-dependent transcription in HEK293T epithelial cells (SuperTOPFlash-based luciferase assay). ( B ) Mean values are displayed; error bars represent S.D.; p - values from one-way ANOVA, Tukey’s multiple comparisons test. ( C ) Mean values displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test; displayed p-values refer to comparisons with WNT3A-treated condition. Figure 4—source data 1. Normalized expression values of AT2 cell markers, CK inhibitors vs. DMSO control. Normalized Axin2 expression values, CK inhibitors vs. DMSO control and related statistics. Raw luciferase data. Normalized luciferase values and related statistics.

Journal: eLife

Article Title: Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

doi: 10.7554/eLife.65811

Figure Lengend Snippet: ( A ) IC261, CX-4945, and DMAT treatments (48 h) lead to downregulation of AT2 cell markers. TTP22 and Emodin (also CK2 inhibitors) do not lead to the same phenotype, possibly due to differences in potency/target affinity. Expression levels relative to DMSO control. Three biological replicates (consisting of 2 technical replicates each) were analyzed per compound. ( B ) Casein Kinase inhibition by IC261, CX-4945, and DMAT (6 h) leads to reduced Axin2 relative expression. Treatment with TTP22 or Emodin does not significantly affect Axin2 levels. More than three biological replicates were analyzed. ( C ) CK inhibition reduced WNT/β-catenin-dependent transcription in HEK293T epithelial cells (SuperTOPFlash-based luciferase assay). ( B ) Mean values are displayed; error bars represent S.D.; p - values from one-way ANOVA, Tukey’s multiple comparisons test. ( C ) Mean values displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test; displayed p-values refer to comparisons with WNT3A-treated condition. Figure 4—source data 1. Normalized expression values of AT2 cell markers, CK inhibitors vs. DMSO control. Normalized Axin2 expression values, CK inhibitors vs. DMSO control and related statistics. Raw luciferase data. Normalized luciferase values and related statistics.

Article Snippet: Chemical compound, drug , TTP22 , Tocris , Tocris:4432 , (10 μM).

Techniques: Expressing, Control, Inhibition, Luciferase

Journal: eLife

Article Title: Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

doi: 10.7554/eLife.65811

Figure Lengend Snippet:

Article Snippet: Chemical compound, drug , TTP22 , Tocris , Tocris:4432 , (10 μM).

Techniques: Recombinant, Transfection, Construct, Plasmid Preparation, Mutagenesis, Reporter Assay, Reverse Transcription, SYBR Green Assay, Sequencing, Software

Figure 4. Compounds promoting AT1 cell differentiation lead to concomitant loss of AT2 marker gene expression and WNT-dependent transcription. (A) IC261, CX-4945, and DMAT treatments (48 h) lead to downregulation of AT2 cell markers. TTP22 and Emodin (also CK2 inhibitors) do not lead to the same phenotype, possibly due to differences in potency/target affinity. Expression levels relative to DMSO control. Three biological replicates (consisting of 2 technical replicates each) were analyzed per compound. (B) Casein Kinase inhibition by IC261, CX-4945, and DMAT (6 h) leads to reduced Axin2 relative expression. Treatment with TTP22 or Emodin does not significantly affect Axin2 levels. More than three biological replicates were analyzed. (C) CK inhibition reduced WNT/β-catenin-dependent transcription in HEK293T epithelial cells (SuperTOPFlash-based luciferase assay). (B) Mean values are displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test. (C) Mean values displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test; displayed p-values refer to comparisons with WNT3A- treated condition.

Journal: eLife

Article Title: Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures

doi: 10.7554/elife.65811

Figure Lengend Snippet: Figure 4. Compounds promoting AT1 cell differentiation lead to concomitant loss of AT2 marker gene expression and WNT-dependent transcription. (A) IC261, CX-4945, and DMAT treatments (48 h) lead to downregulation of AT2 cell markers. TTP22 and Emodin (also CK2 inhibitors) do not lead to the same phenotype, possibly due to differences in potency/target affinity. Expression levels relative to DMSO control. Three biological replicates (consisting of 2 technical replicates each) were analyzed per compound. (B) Casein Kinase inhibition by IC261, CX-4945, and DMAT (6 h) leads to reduced Axin2 relative expression. Treatment with TTP22 or Emodin does not significantly affect Axin2 levels. More than three biological replicates were analyzed. (C) CK inhibition reduced WNT/β-catenin-dependent transcription in HEK293T epithelial cells (SuperTOPFlash-based luciferase assay). (B) Mean values are displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test. (C) Mean values displayed; error bars represent S.D.; p-values from one-way ANOVA, Tukey’s multiple comparisons test; displayed p-values refer to comparisons with WNT3A- treated condition.

Article Snippet: or resource Designation Source or reference Identifiers Additional information Chemical compound, drug Emodin Tocris Tocris:3811 (10 μM) Chemical compound, drug TTP22 Tocris Tocris:4432 (10 μM) Chemical compound, drug IC261 Sigma Sigma:I0658 (10 μM) Chemical compound, drug CX- 4945 Enzo Life Sciences Enzo Life Sciences: ENZ- CHM151 (10 μM) Chemical compound, drug DMAT Sigma Sigma:SML2044 (10 μM) Chemical compound, drug IWR- 1 Sigma Sigma:I0161 (10 μM) Commercial assay or kit Dual- Luciferase Reporter Assay System Promega Promega:E1910 Commercial assay or kit NucleoSpin RNA kit Macherey- Nagel MachereyNagel:740955.50 Commercial assay or kit Superscript III Reverse Transcriptase system Invitrogen Thermo Fisher Scientific:18080093 Commercial assay or kit DyNAmo ColorFlash SYBR green qPCR kit Thermo Scientific Thermo Fisher Scientific:F416XL Sequencebased reagent qPCR This paper Supplementary file 1 Software, algorithm Fiji/ImageJ 1.53 c Schindelin et al., 2012; doi:10.1038/nmeth.2019 RRID:SCR_002285 Software, algorithm GraphPad Prism 8 GraphPad RRID:SCR_002798 Continued

Techniques: Cell Differentiation, Marker, Gene Expression, Expressing, Control, Inhibition, Luciferase