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Image Search Results
Journal: Aging (Albany NY)
Article Title: Myoblasts rely on TAp63 to control basal mitochondria respiration
doi: 10.18632/aging.101668
Figure Lengend Snippet: TAp63 knock-down affects the expression of genes involved in proliferation and metabolism. ( A ) RT-qPCR of p63 mRNA (Trp63) and ( B ) p21 (Cdkn1a) performed in proliferating Scr, sh1-p63 and sh2-p63 clones. Results are shown as average of three experiments ± s.d. *p<0.05. ( C ) Volcano plot showing -log 10 (FDR) in function of the log 2 (FC) for coding genes in Scr and sh1-p63. Green points indicate significantly expressed genes ( D ) GO terms of microarray performed on significantly modulated genes in C2C7 myoblasts ( C ). Panther was used for biological process ( http://pantherdb.org /). ( E ) Heatmap expression level of genes from “ positive regulation of cell proliferation ” and “ regulation of cellular metabolism ” categories. ( F ) RT-qPCR analysis of mRNA level of modulated genes. Results are shown as average of three experiments ± s.d. *p<0.05, **p<0.01.
Article Snippet:
Techniques: Knockdown, Expressing, Quantitative RT-PCR, Clone Assay, Microarray