tissue-specific rna-seq data Search Results


cell rna seq data  (Broad Clinical Labs)
96
Broad Clinical Labs cell rna seq data
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Cell Rna Seq Data, supplied by Broad Clinical Labs, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cell rna seq data/product/Broad Clinical Labs
Average 96 stars, based on 1 article reviews
cell rna seq data - by Bioz Stars, 2026-06
96/100 stars
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rna seq data  (Human Protein Atlas)
86
Human Protein Atlas rna seq data
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Rna Seq Data, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rna seq data/product/Human Protein Atlas
Average 86 stars, based on 1 article reviews
rna seq data - by Bioz Stars, 2026-06
86/100 stars
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rna-seq data  (Epigenomics ag)
90
Epigenomics ag rna-seq data
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Rna Seq Data, supplied by Epigenomics ag, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/rna-seq data/product/Epigenomics ag
Average 90 stars, based on 1 article reviews
rna-seq data - by Bioz Stars, 2026-06
90/100 stars
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scrna-seq porter database  (Broad Institute Inc)
90
Broad Institute Inc scrna-seq porter database
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Scrna Seq Porter Database, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/scrna-seq porter database/product/Broad Institute Inc
Average 90 stars, based on 1 article reviews
scrna-seq porter database - by Bioz Stars, 2026-06
90/100 stars
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single cell rna-seq (scrna-seq) porter database  (Broad Institute Inc)
90
Broad Institute Inc single cell rna-seq (scrna-seq) porter database
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Single Cell Rna Seq (Scrna Seq) Porter Database, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/single cell rna-seq (scrna-seq) porter database/product/Broad Institute Inc
Average 90 stars, based on 1 article reviews
single cell rna-seq (scrna-seq) porter database - by Bioz Stars, 2026-06
90/100 stars
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porter database  (Broad Institute Inc)
90
Broad Institute Inc porter database
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Porter Database, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/porter database/product/Broad Institute Inc
Average 90 stars, based on 1 article reviews
porter database - by Bioz Stars, 2026-06
90/100 stars
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graphpad prism tool  (GraphPad Software Inc)
90
GraphPad Software Inc graphpad prism tool
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Graphpad Prism Tool, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/graphpad prism tool/product/GraphPad Software Inc
Average 90 stars, based on 1 article reviews
graphpad prism tool - by Bioz Stars, 2026-06
90/100 stars
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arabidopsis rna-seq database  (SusTech GmbH)
90
SusTech GmbH arabidopsis rna-seq database
FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: <t>Bulk</t> <t>RNA-Seq</t> analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.
Arabidopsis Rna Seq Database, supplied by SusTech GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/arabidopsis rna-seq database/product/SusTech GmbH
Average 90 stars, based on 1 article reviews
arabidopsis rna-seq database - by Bioz Stars, 2026-06
90/100 stars
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roku  (Epigenomics ag)
90
Epigenomics ag roku
The tissue specificity of human lncRNAs and protein-coding genes. The tissue specificity of 6414 lncRNAs and 17,806 protein- coding genes analyzed using RNA-seq data from the Human Protein Atlas Project (Expression Atlas ID: E-MTAB-2836). a Distributions of tissue-specificity scores calculated <t>for</t> <t>lncRNA</t> and protein- coding genes. b Fraction of specifically expressed genes determined to be outliers by <t>ROKU</t>
Roku, supplied by Epigenomics ag, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/roku/product/Epigenomics ag
Average 90 stars, based on 1 article reviews
roku - by Bioz Stars, 2026-06
90/100 stars
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chip-seq  (Epigenomics ag)
90
Epigenomics ag chip-seq
The tissue specificity of human lncRNAs and protein-coding genes. The tissue specificity of 6414 lncRNAs and 17,806 protein- coding genes analyzed using RNA-seq data from the Human Protein Atlas Project (Expression Atlas ID: E-MTAB-2836). a Distributions of tissue-specificity scores calculated <t>for</t> <t>lncRNA</t> and protein- coding genes. b Fraction of specifically expressed genes determined to be outliers by <t>ROKU</t>
Chip Seq, supplied by Epigenomics ag, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/chip-seq/product/Epigenomics ag
Average 90 stars, based on 1 article reviews
chip-seq - by Bioz Stars, 2026-06
90/100 stars
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ggplot2 package  (RStudio)
90
RStudio ggplot2 package
The tissue specificity of human lncRNAs and protein-coding genes. The tissue specificity of 6414 lncRNAs and 17,806 protein- coding genes analyzed using RNA-seq data from the Human Protein Atlas Project (Expression Atlas ID: E-MTAB-2836). a Distributions of tissue-specificity scores calculated <t>for</t> <t>lncRNA</t> and protein- coding genes. b Fraction of specifically expressed genes determined to be outliers by <t>ROKU</t>
Ggplot2 Package, supplied by RStudio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ggplot2 package/product/RStudio
Average 90 stars, based on 1 article reviews
ggplot2 package - by Bioz Stars, 2026-06
90/100 stars
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long-read rna-seq data  (Oxford Nanopore)
90
Oxford Nanopore long-read rna-seq data
The tissue specificity of human lncRNAs and protein-coding genes. The tissue specificity of 6414 lncRNAs and 17,806 protein- coding genes analyzed using RNA-seq data from the Human Protein Atlas Project (Expression Atlas ID: E-MTAB-2836). a Distributions of tissue-specificity scores calculated <t>for</t> <t>lncRNA</t> and protein- coding genes. b Fraction of specifically expressed genes determined to be outliers by <t>ROKU</t>
Long Read Rna Seq Data, supplied by Oxford Nanopore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/long-read rna-seq data/product/Oxford Nanopore
Average 90 stars, based on 1 article reviews
long-read rna-seq data - by Bioz Stars, 2026-06
90/100 stars
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FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: Bulk RNA-Seq analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.

Journal: Frontiers in immunology

Article Title: Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.

doi: 10.3389/fimmu.2023.1113883

Figure Lengend Snippet: FIGURE 1 High-fat diet (HFD) promotes non-alcoholic fatty liver disease (NAFLD) and Caspase-11 deficiency decreases lipid droplet, steatosis score, and NAS score in HFD-induced NAFLD but does not change liver weight or gross anatomic fatty liver pathology. (A) Experimental diet timeline. 8-10 weeks old Wild-type (WT) male mice and Caspase-11 deficient (Casp11–/–) mice were fed HFD or normal chow diet (NCD) for 12 weeks. (B) Body weight (n = 15). (C) Liver weight (n = 15). (D) Plasma cholesterol levels (n = 3). (E) Representative images showed that HFD feeding changed liver color to light yellow color. (F) Representative 20X images of hematoxylin and eosin (H&E) staining showing hepatic steatosis in 12-week HFD-fed WT and Casp11–/– male mice compared to 12-week NCD. Scale bar 100 µm. (G). Description and grades of NAS scare. NAFLD activity score analysis indicated that lipids accumulation as judged by liver steatosis and ballooning is precedent to liver inflammation. In grade 1, when steatosis reaches 5-33%, and ballooning reaches mild, inflammation is minimal. Steatosis was in the graded section as: are 0, steatotic; 0% to 1, 5% greater than 5% to 33% of hepatocytes are steatotic; 2, greater than 33% to as: 66%; 0, absent; and 3, 1, greater mild (focal; than 66%. involving Ballooning fewer than 3 hepatocytes); 2, moderate (focal and involving 3 or more hepatocytes or multifocal); and 3, severe (multifocal, with more than 2 foci of 3 or more hepatocytes). (0 or 1 Inflammation focus per 20× was field); graded 2, as: mild 0, (2 absent; foci); 3, moderate (3 foci); and 4, severe (4 or more foci per 20× field). (H) Total NAS score for WT-NCD (n = 5), WT-HFD (n = 8), Casp11–/–NCD (n = 5) and Casp11–/–HFD (n = 8). (I) Hepatic steatosis score. (J) Hepatocyte ballooning. (K) Lobular inflammation. (L) Principal component analysis (PCA) demonstrating that WT-NCD, WT-HFD, Casp11–/–NCD, and Casp11–/–HFD mice are transcriptionally distinct (n = 3). (M) Volcano plot analysis showed the 3895 differentially expressed genes (DEGs) in the WT liver of 12-week HFD compared to12-week NCD control. Among 3895 DEGs, 2918 genes were significantly upregulated (red), and 977 genes downregulated (blue). (FC) > 1.5 and p < 0.05. Statistical Analysis: Bulk RNA-Seq analysis was performed using Qlucore Omics Explorer. PCA plot generated using significantly differentially regulated genes). Volcano plot generated using GraphPad Prism with significantly differentially regulated genes. Statistical Analysis: One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. ns, Non-significant.

Article Snippet: Furthermore, we analyzed the expression of caspase-4 in 45 immune cell types from single-cell RNA-seq data collected from the MIT Broad Institute Single Cell RNA-seq (scRNA-seq) Porter database (https://singlecell.broadinstitute.org/single_cell/study/SCP1845/ cross-tissue-immune-cell-analysis-reveals-tissue-specific-features-inhumans?genes=casp4&tab=distribution#study-visualize) (104).

Techniques: Clinical Proteomics, Staining, Activity Assay, Control, RNA Sequencing, Generated

FIGURE 2 HFD upregulates the expressions of proinflammatory, NASH-related hepatic macrophage markers, GBPs, caspase-11, and increases N-terminal GSDMD cleavage. (A, B) The structure of hepatic acinus suggests that the liver is the first organ exposed to endotoxins-rich and Gram bacteria-rich blood in the body. Liver parenchymal and nonparenchymal cells are organized into structures called “acinus”. Hepatic acini form hexagonal structures with a central vein and portal triad at the vertices. The hepatic acinus can be histologically divided into three zones. Zone 1 represents the portal triad which includes a hepatic artery, a portal vein, and a bile duct. Zone 2 represents the parenchymal area, structurally consisting primarily of hepatocytes with a central vasculature composed of liver sinusoidal endothelial cells (LSECs). Mature immune cells including B cells, T cells, innate-like lymphoid cells (ILCs), natural killer cells (NK cells), and tissue-resident macrophages (Kupffer cells) reside in hepatic acinus zone 1 and 2. Zone 3 represents the central vein, the innermost hepatocytes, and infiltrating immune cells. The portal vein contains nutrient-rich, endotoxins-rich, and gram bacteria-rich blood. (C) Noncanonical pyroptosis is caspase-4 (human), caspase-11 (mouse) dependent. Guanylate binding proteins (GBPs) promote the outer membrane vesicles from gram-bacteria to activate caspase-11. Intracellular sources of inflammation (including LPS and oxidized phospholipids) directly bind to caspase-4/-11. Caspase-4/-11 cleaves gasdermin-D to initiate noncanonical pyroptosis. (D) The expressions of caspase-11 in the liver were in an upregulation trend in high-fat diet-fed wild-type mice. The microarray data were achieved from the NIH-NCBI-Geo-Profiles database (GDS4811). (E) Caspase-4 expression in 27 human tissues. The expression of caspase-4 in the liver is at a medium level among all 27 human tissues. Caspase-4 RNA- Seq data were analyzed from the NIH-NCBI-Gene database (https://www.ncbi.nlm.nih.gov/gene/837). (F) Caspase-4 expression in 45 hepatic cell types. Caspase-4 is expressed in all 40 immune cell types, the single-cell RNA-Seq data were analyzed from the MIT Broad Institute Single Cell RNA-Seq (scRNA-Seq) Porter database (https://singlecell.broadinstitute.org/single_cell/study/SCP1845/cross-tissue-immune-cell-analysis-reveals-tissue-specific- features-in-humans?genes=casp4&tab=distribution#study-visualize). Among 45 immune cell types identified in scRNA-Seq, 19 immune cell types are significantly enriched in the human liver including dendritic cell 1 (DC1), DC2, classical monocytes, non-classical monocytes, erythrophagocytic macrophages, mononuclear phagocytes (MNP)/B doublets, age-associated B cells (ABCs), plasma cells, Plasmablasts, MNP/B doublets, T/B doublets, mucosal-associated invariant T (MAIT), T_CD4/CD8, T effector memory (Tem)/effector memory re-expressing CD45RA (emra)_CD8, T resident memory cell/effector memory cell (Trm/em)_CD8, gamma-delta T cell (Tgd)_CRTAM+, Cycling T cell & natural killer cell (NK), NK_CD16+, and NK- CD56bright_CD16-. (G) 12-week HFD promotes expression of HMF activation mediators in the WT liver. 8-10 weeks old male WT mice were fed with HFD for 12 weeks. Heatmap of significant, differentially regulated macrophage (HMF) genes. (H) Bulk RNA-seq expression (mean transcripts per kilobase million, TPM) of macrophage mediators. (I) Schematic representing caspase-4/11 pathway genes. (J) Bulk RNA-seq expression (mean TPM) of noncanonical pyroptosis-associated mediators. (K) Western blot analysis showed that HFD feeding increased caspase-11 and N-terminal GSDMD cleavage. Statistical Analysis: Bulk RNAseq analysis was performed using Qlucore Omics Explorer. Heatmap was generated using significantly differentially regulated genes (p.adj < 0.01). Differential gene expression presented as Z-score calculated from log2 transformed TPM. *P < 0.05, **p < 0.01.

Journal: Frontiers in immunology

Article Title: Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.

doi: 10.3389/fimmu.2023.1113883

Figure Lengend Snippet: FIGURE 2 HFD upregulates the expressions of proinflammatory, NASH-related hepatic macrophage markers, GBPs, caspase-11, and increases N-terminal GSDMD cleavage. (A, B) The structure of hepatic acinus suggests that the liver is the first organ exposed to endotoxins-rich and Gram bacteria-rich blood in the body. Liver parenchymal and nonparenchymal cells are organized into structures called “acinus”. Hepatic acini form hexagonal structures with a central vein and portal triad at the vertices. The hepatic acinus can be histologically divided into three zones. Zone 1 represents the portal triad which includes a hepatic artery, a portal vein, and a bile duct. Zone 2 represents the parenchymal area, structurally consisting primarily of hepatocytes with a central vasculature composed of liver sinusoidal endothelial cells (LSECs). Mature immune cells including B cells, T cells, innate-like lymphoid cells (ILCs), natural killer cells (NK cells), and tissue-resident macrophages (Kupffer cells) reside in hepatic acinus zone 1 and 2. Zone 3 represents the central vein, the innermost hepatocytes, and infiltrating immune cells. The portal vein contains nutrient-rich, endotoxins-rich, and gram bacteria-rich blood. (C) Noncanonical pyroptosis is caspase-4 (human), caspase-11 (mouse) dependent. Guanylate binding proteins (GBPs) promote the outer membrane vesicles from gram-bacteria to activate caspase-11. Intracellular sources of inflammation (including LPS and oxidized phospholipids) directly bind to caspase-4/-11. Caspase-4/-11 cleaves gasdermin-D to initiate noncanonical pyroptosis. (D) The expressions of caspase-11 in the liver were in an upregulation trend in high-fat diet-fed wild-type mice. The microarray data were achieved from the NIH-NCBI-Geo-Profiles database (GDS4811). (E) Caspase-4 expression in 27 human tissues. The expression of caspase-4 in the liver is at a medium level among all 27 human tissues. Caspase-4 RNA- Seq data were analyzed from the NIH-NCBI-Gene database (https://www.ncbi.nlm.nih.gov/gene/837). (F) Caspase-4 expression in 45 hepatic cell types. Caspase-4 is expressed in all 40 immune cell types, the single-cell RNA-Seq data were analyzed from the MIT Broad Institute Single Cell RNA-Seq (scRNA-Seq) Porter database (https://singlecell.broadinstitute.org/single_cell/study/SCP1845/cross-tissue-immune-cell-analysis-reveals-tissue-specific- features-in-humans?genes=casp4&tab=distribution#study-visualize). Among 45 immune cell types identified in scRNA-Seq, 19 immune cell types are significantly enriched in the human liver including dendritic cell 1 (DC1), DC2, classical monocytes, non-classical monocytes, erythrophagocytic macrophages, mononuclear phagocytes (MNP)/B doublets, age-associated B cells (ABCs), plasma cells, Plasmablasts, MNP/B doublets, T/B doublets, mucosal-associated invariant T (MAIT), T_CD4/CD8, T effector memory (Tem)/effector memory re-expressing CD45RA (emra)_CD8, T resident memory cell/effector memory cell (Trm/em)_CD8, gamma-delta T cell (Tgd)_CRTAM+, Cycling T cell & natural killer cell (NK), NK_CD16+, and NK- CD56bright_CD16-. (G) 12-week HFD promotes expression of HMF activation mediators in the WT liver. 8-10 weeks old male WT mice were fed with HFD for 12 weeks. Heatmap of significant, differentially regulated macrophage (HMF) genes. (H) Bulk RNA-seq expression (mean transcripts per kilobase million, TPM) of macrophage mediators. (I) Schematic representing caspase-4/11 pathway genes. (J) Bulk RNA-seq expression (mean TPM) of noncanonical pyroptosis-associated mediators. (K) Western blot analysis showed that HFD feeding increased caspase-11 and N-terminal GSDMD cleavage. Statistical Analysis: Bulk RNAseq analysis was performed using Qlucore Omics Explorer. Heatmap was generated using significantly differentially regulated genes (p.adj < 0.01). Differential gene expression presented as Z-score calculated from log2 transformed TPM. *P < 0.05, **p < 0.01.

Article Snippet: Furthermore, we analyzed the expression of caspase-4 in 45 immune cell types from single-cell RNA-seq data collected from the MIT Broad Institute Single Cell RNA-seq (scRNA-seq) Porter database (https://singlecell.broadinstitute.org/single_cell/study/SCP1845/ cross-tissue-immune-cell-analysis-reveals-tissue-specific-features-inhumans?genes=casp4&tab=distribution#study-visualize) (104).

Techniques: Bacteria, Binding Assay, Membrane, Microarray, Expressing, RNA Sequencing, Cell Analysis, Clinical Proteomics, Activation Assay, Western Blot, Generated, Gene Expression, Transformation Assay

FIGURE 3 High-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) drives the increase of NASH-related F4/80+ hepatic macrophages (HMFs) in WT mice, which are caspase-11 activation-independent. 8-10 weeks old male WT and Casp11–/– mice were fed HFD for 12 weeks. (A) Bulk RNA-seq expression (TPM) of NASH-associated activated HMF genes. (B) Representative flow cytometry gating of HMF. Gated on CD45+ > CD11b+ Ly6G- > Ly6Clow MHCIIhigh. (C) F4/80+ mean fluorescence intensity (MFI) for HMF populations. Statistical Analysis: Bulk RNAseq analysis was performed using Qlucore Omics Explorer. PCA generated using significantly differentially regulated genes (p.adj < 0.01). Included genes were significant (p < 0.05) in multi-variant analysis (Two-Way ANOVA). Marked significance (*) determined by One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. Flow cytometry data was analyzed with FlowJo, and statistical analysis was performed using Prism. One-Way ANOVA.

Journal: Frontiers in immunology

Article Title: Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.

doi: 10.3389/fimmu.2023.1113883

Figure Lengend Snippet: FIGURE 3 High-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) drives the increase of NASH-related F4/80+ hepatic macrophages (HMFs) in WT mice, which are caspase-11 activation-independent. 8-10 weeks old male WT and Casp11–/– mice were fed HFD for 12 weeks. (A) Bulk RNA-seq expression (TPM) of NASH-associated activated HMF genes. (B) Representative flow cytometry gating of HMF. Gated on CD45+ > CD11b+ Ly6G- > Ly6Clow MHCIIhigh. (C) F4/80+ mean fluorescence intensity (MFI) for HMF populations. Statistical Analysis: Bulk RNAseq analysis was performed using Qlucore Omics Explorer. PCA generated using significantly differentially regulated genes (p.adj < 0.01). Included genes were significant (p < 0.05) in multi-variant analysis (Two-Way ANOVA). Marked significance (*) determined by One-Way ANOVA. *p < 0.05, **p < 0.001, ***p < 0.0001 ****p < 0.0001. Flow cytometry data was analyzed with FlowJo, and statistical analysis was performed using Prism. One-Way ANOVA.

Article Snippet: Furthermore, we analyzed the expression of caspase-4 in 45 immune cell types from single-cell RNA-seq data collected from the MIT Broad Institute Single Cell RNA-seq (scRNA-seq) Porter database (https://singlecell.broadinstitute.org/single_cell/study/SCP1845/ cross-tissue-immune-cell-analysis-reveals-tissue-specific-features-inhumans?genes=casp4&tab=distribution#study-visualize) (104).

Techniques: Activation Assay, RNA Sequencing, Expressing, Cytometry, Generated, Variant Assay, Flow Cytometry

The tissue specificity of human lncRNAs and protein-coding genes. The tissue specificity of 6414 lncRNAs and 17,806 protein- coding genes analyzed using RNA-seq data from the Human Protein Atlas Project (Expression Atlas ID: E-MTAB-2836). a Distributions of tissue-specificity scores calculated for lncRNA and protein- coding genes. b Fraction of specifically expressed genes determined to be outliers by ROKU

Journal: Biology Direct

Article Title: Computational prediction of lncRNA-mRNA interactionsby integrating tissue specificity in human transcriptome

doi: 10.1186/s13062-017-0183-4

Figure Lengend Snippet: The tissue specificity of human lncRNAs and protein-coding genes. The tissue specificity of 6414 lncRNAs and 17,806 protein- coding genes analyzed using RNA-seq data from the Human Protein Atlas Project (Expression Atlas ID: E-MTAB-2836). a Distributions of tissue-specificity scores calculated for lncRNA and protein- coding genes. b Fraction of specifically expressed genes determined to be outliers by ROKU

Article Snippet: The values in parenthesses indicate the ratio of tissue-specific genes to total. (PDF 13 kb) Additional file 5 Number of tissue-specific lncRNA and mRNAs detected as outlier expression by applying ROKU [ ] to RNA-seq data derived from NIH Epigenomics Roadmap project [ ].

Techniques: RNA Sequencing, Expressing