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ATCC
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ATCC
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Santa Cruz Biotechnology
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CEM Corporation
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Broad Institute Inc
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ONTOP PHARMACEUTICALS LIMITED
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Image Search Results
Journal: PLOS One
Article Title: Ivermectin inhibits ER, HER2, and TGF-β pathways in ER-positive and endocrine-resistant breast cancer cells
doi: 10.1371/journal.pone.0348260
Figure Lengend Snippet: MTT assay measured cell viability of ER-positive breast cancer cells: (A) MCF-7 and (B) T-47D, were treated with (+E 2 ) or without (−E 2 ) 17β-estradiol at physiologic level (10 nM E 2 ) in the presence of nontoxic concentrations of IVM (1, 3, 5 μM) or 4-OHT (5, 10 μM) as a positive control for 5 days. (C–E) The inhibitory effect of IVM on ERα and HER2 protein levels of ER-positive breast cancer was performed after the treatments with various concentrations of IVM with (+E 2 ) or without (−E 2 ) 17β-estradiol (10 nM E 2 ) for 24 h in MCF-7. (F) mRNA expression of the ESR1 gene (ERα) was determined by qPCR analysis in MCF-7 cells. The graphs showed the mean ± SEM. The blue and red asterisks highlight the significant differences in comparison to non-treatment without (−E 2 ) and with (+E 2 ), respectively. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 versus the non-treatment control (n = 3).
Article Snippet: The ER-positive breast cancer cell lines: MCF-7 and T-47D, along with the
Techniques: MTT Assay, Positive Control, Expressing, Comparison, Control