system generator library Search Results


enamine fragment library  (Life Chemicals Inc)
93
Life Chemicals Inc enamine fragment library
Enamine Fragment Library, supplied by Life Chemicals Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/us11535597-51-41-50?v=Life+Chemicals+Inc
Average 93 stars, based on 1 article reviews
enamine fragment library - by Bioz Stars, 2026-07
93/100 stars
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dna library generation  (Active Motif)
90
Active Motif dna library generation
Dna Library Generation, supplied by Active Motif, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/pmc04347287-82-0-6?v=Active+Motif
Average 90 stars, based on 1 article reviews
dna library generation - by Bioz Stars, 2026-07
90/100 stars
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spectralgtm library generation system  (KLA Tencor)
90
KLA Tencor spectralgtm library generation system
Spectralgtm Library Generation System, supplied by KLA Tencor, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/us07656512-202-20-26?v=KLA+Tencor
Average 90 stars, based on 1 article reviews
spectralgtm library generation system - by Bioz Stars, 2026-07
90/100 stars
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fourth generation delopen library (4.2 billion compounds, 27 sub-libraries)  (WuXi AppTec)
90
WuXi AppTec fourth generation delopen library (4.2 billion compounds, 27 sub-libraries)
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Fourth Generation Delopen Library (4.2 Billion Compounds, 27 Sub Libraries), supplied by WuXi AppTec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/bio_rxiv__2025__01__15__632061-8-11-20?v=WuXi+AppTec
Average 90 stars, based on 1 article reviews
fourth generation delopen library (4.2 billion compounds, 27 sub-libraries) - by Bioz Stars, 2026-07
90/100 stars
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next-generation sequencing libraries  (Nextera AS)
90
Nextera AS next-generation sequencing libraries
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Next Generation Sequencing Libraries, supplied by Nextera AS, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/pm30059786-357-2-6?v=Nextera+AS
Average 90 stars, based on 1 article reviews
next-generation sequencing libraries - by Bioz Stars, 2026-07
90/100 stars
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second-generation dna-templated macrocycle libraries  (Broad Institute Inc)
90
Broad Institute Inc second-generation dna-templated macrocycle libraries
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Second Generation Dna Templated Macrocycle Libraries, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/pmc06014893__NIHMS947221___supplement___1-0-0-47?v=Broad+Institute+Inc
Average 90 stars, based on 1 article reviews
second-generation dna-templated macrocycle libraries - by Bioz Stars, 2026-07
90/100 stars
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mis library generation software  (Microbial ID Inc)
90
Microbial ID Inc mis library generation software
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Mis Library Generation Software, supplied by Microbial ID Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/10__1128_slash_aem__70__12__7378___7387__2004-85-67-71?v=Microbial+ID+Inc
Average 90 stars, based on 1 article reviews
mis library generation software - by Bioz Stars, 2026-07
90/100 stars
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cdna fragments generated by nextera xt library preparation  (Nextera AS)
90
Nextera AS cdna fragments generated by nextera xt library preparation
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Cdna Fragments Generated By Nextera Xt Library Preparation, supplied by Nextera AS, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/pmc06321908-214-1-5?v=Nextera+AS
Average 90 stars, based on 1 article reviews
cdna fragments generated by nextera xt library preparation - by Bioz Stars, 2026-07
90/100 stars
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the rna-seq library was generated  (MWG-Biotech ag)
90
MWG-Biotech ag the rna-seq library was generated
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
The Rna Seq Library Was Generated, supplied by MWG-Biotech ag, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/pm26918393-51-1-7?v=MWG-Biotech+ag
Average 90 stars, based on 1 article reviews
the rna-seq library was generated - by Bioz Stars, 2026-07
90/100 stars
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third-generation genomic library  (Oxford Nanopore)
90
Oxford Nanopore third-generation genomic library
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Third Generation Genomic Library, supplied by Oxford Nanopore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/pmc09144602-108-1-11?v=Oxford+Nanopore
Average 90 stars, based on 1 article reviews
third-generation genomic library - by Bioz Stars, 2026-07
90/100 stars
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second-generation “geko” grna library  (Broad Institute Inc)
90
Broad Institute Inc second-generation “geko” grna library
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Second Generation “Geko” Grna Library, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/us11459613-285-23-37?v=Broad+Institute+Inc
Average 90 stars, based on 1 article reviews
second-generation “geko” grna library - by Bioz Stars, 2026-07
90/100 stars
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single nuclei library generation  (Northport Systems Inc)
90
Northport Systems Inc single nuclei library generation
( A ) <t>DELopen</t> screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.
Single Nuclei Library Generation, supplied by Northport Systems Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/system+generator+library/pmc12276969-339-16-3?v=Northport+Systems+Inc
Average 90 stars, based on 1 article reviews
single nuclei library generation - by Bioz Stars, 2026-07
90/100 stars
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Image Search Results


( A ) DELopen screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.

Journal: bioRxiv

Article Title: DNA-encoded Library Screening Uncovers Potent DNMT2 Inhibitors Targeting a Cryptic Allosteric Binding Site

doi: 10.1101/2025.01.15.632061

Figure Lengend Snippet: ( A ) DELopen screening workflow. DELopen libraries consist of 4.2B compounds encoded by individual DNA barcodes. During affinity selection, small molecule-DNA-conjugates are enriched, while non-binders are washed away. The pipeline’s last step is the sequencing and decoding of new ligand structures. ( B ) Conditions used during the DELopen screening: In condition A native DNMT2 without additives was used; condition B: DNMT2 and SAH (100 µM) were mixed to block the SAH binding site; condition C: DNMT2 was incubated with tRNA Asp (10 µM). Most full-length molecules were enriched in condition ABC (unaffected by competitors), from which 5 selected compounds 1 – 5 were chosen for off-DNA synthesis and downstream characterization. ( C ) Enriched triazine-based compounds selected from ABC. ( D ) Peptidomimetic compounds enriched in ABC and chosen for further study. Building blocks BB1–BB4 are highlighted accordingly.

Article Snippet: DEL screening against human DNMT2 protein was performed with the fourth generation DELopen library (4.2 billion compounds, 27 sub-libraries) by WuXi AppTec.

Techniques: Selection, Sequencing, Blocking Assay, Binding Assay, Incubation, DNA Synthesis