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Image Search Results
Journal: Cell Death and Differentiation
Article Title: Powering stem cell decisions with ubiquitin
doi: 10.1038/cdd.2017.142
Figure Lengend Snippet: Upper panel: in stem cells, the E3 ubiquitin ligase SCFFBXO15 recognizes acetylated KBP, thereby inducing its ubiquitylation and proteasomal degradation. This limits mitochondrial biogenesis. Lower panel: in differentiating cells, acetylation of KBP and expression of FBXO15 are reduced, resulting in KBP stabilization and enhanced mitochondrial biogenesis
Article Snippet: MR is cofounder and consultant to
Techniques: Ubiquitin Proteomics, Expressing