Journal: bioRxiv

Article Title: Integrating Artificial Intelligence and Bioinformatics Methods to Identify Disruptive STAT1 Variants Impacting Protein Stability and Function

doi: 10.1101/2024.10.04.616446

Figure Lengend Snippet: Selection of nsSNPs of STAT1 gene.

Article Snippet: Identification of nsSNPs in STAT1 protein domains The FASTA sequence of the STAT1 protein was submitted to the InterPro server ( https://www.ebi.ac.uk/interpro ).

Techniques: Selection

Journal: Endocrine-related cancer

Article Title: Signal transducer and activator of transcription 5A/B in prostate and breast cancers

doi: 10.1677/ERC-08-0013

Figure Lengend Snippet: Chromosomal mapping and sequence identity between human and mouse signal transducer and activator of transcriptions (STATs)

Article Snippet: In the mouse, Stat1 and Stat4 are located on chromosome 1 (band 1 C1.1) ( Schindler et al . 1992 , Yamamoto et al . 1994 ); Stat2 and Stat6 are on chromosome 10 (band 10 D3) ( Fu et al . 1992 , Quelle et al . 1995 ); and Stat3 , Stat5a , and Stat5b map to chromosome 11 (band 11 D) ( Zhong et al . 1994 a , Copeland et al . 1995 , Shi et al . 1996 , Levy et al . 1998 ; ). table ft1 table-wrap mode="anchored" t5 caption a7 STAT Human Mouse % Identity References Amino acid Chromosome Amino acid Chromosome STAT1 750 2 749 1 93 Schindler et al . (1992) and Haddad et al . (1998) STAT2 846 12 915 10 64 Fu et al . (1992) and Goureau et al . (2001) STAT3 769 17 769 11 99 Zhong et al . (1994 a ) and Choi et al . (1996) STAT4 748 2 748 1 94 Yamamoto et al . (1994 , 1997) STAT5A 794 17 793 11 96 Mui et al . (1995) and Lin et al . (1996) STAT5B 787 17 786 11 96 Mui et al . (1995) and Lin et al . (1996) STAT6 847 12 837 10 85 Quelle et al . (1995) and Leek et al . (1997) Open in a separate window Chromosomal mapping and sequence identity between human and mouse signal transducer and activator of transcriptions (STATs) STATs are proteins of 750–900 amino acids (90–115 kDa) with five structurally and functionally conserved domains that allow the transduction of ligand-specific signals ( Schindler & Darnell 1995 ).

Techniques: Sequencing