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Image Search Results
Journal:
Article Title: Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line
doi: 10.1113/jphysiol.2004.075069
Figure Lengend Snippet: In each case, a representative experiment is shown in the left panel. Summary graphs on the right confirm the significant reduction of current amplitudes by amiloride and Psalmopoeus venom. A, 30 mm amiloride inhibits ASIC responses by 84.4 ± 1.2%; they recover to 93.3 ± 3.4% of control upon wash-out. B, in response to Psalmopeus venom (1 : 1000), currents are reduced by 90.8 ± 3.0% and return to 80.9 ± 1.4% after wash-out. By contrast, APETx2 had no significant effect on acid-evoked responses. C, at a concentration of 1 μm, the toxin reduced currents to 95.0 ± 3.8% of control (91.4 ± 5.4% of control on wash-out response).
Article Snippet: Amiloride and lactic acid were obtained from Sigma;
Techniques: Control, Concentration Assay