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Image Search Results
Journal: Chinese medicine
Article Title: Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.
doi: 10.1186/s13020-025-01135-9
Figure Lengend Snippet: Fig. 2 Effect of DZP treatment on midbrain tissue in PD mice. A Immunofluorescence results of TH and α-syn in the substantia nigra of mouse midbrain. Scale bars: 300 μm or 100 μm. B Statistical map of TH positive expression area. C Statistical map of α-syn positive expression area. n = 10. The data are mean ± SD; #P < 0.05; ##P < 0.01; ###P < 0.001 compared to the PD group.*P < 0.05; **P < 0.01; ***P < 0.001 compared to the PD group
Article Snippet: The sections were then incubated sequentially with primary antibodies against Tyrosine Hydroxylase (TH) (Proteintech, Wuhan, China), GFAP(Proteintech, Wuhan, China), TNF-α (Proteintech, Wuhan, China), NeuN (Proteintech, Wuhan, China), GPX4 (Proteintech, Wuhan, China) and
Techniques: Immunofluorescence, Expressing
Journal: Molecular Neurodegeneration
Article Title: LRP1 is a neuronal receptor for α-synuclein uptake and spread
doi: 10.1186/s13024-022-00560-w
Figure Lengend Snippet: LRP1 regulates α-Syn uptake in iPSNs. a and b , α-Syn uptake in WT and LRP1 -KO iPSNs measured by flow cytometry (100 nM, 3 h of treatment). c Representative images of WT or LRP1 -KO iPSNs after α-Syn uptake. Scale bars, 20 μm. d and e , Transferrin (Tfn) uptake in WT and LRP1 -KO iPSNs measured by flow cytometry (300 nM, 3 h of treatment). f Uptake of α-Syn and Tfn in the presence of increasing concentrations of RAP. g EM images showing the structure of α-Syn oligomers and preformed fibrils (PFFs) used in panel h. Scale bars, 200 nm. h Uptake of α-Syn oligomers and PFFs in WT and LRP1 -KO iPSNs (100 nM monomer equivalent, 3 h of treatment). All experiments in ( a , b , d , e , f and h ) were performed in technical duplicates or triplicates over three independent experiments. All data are expressed as mean ± s.d. with individual data points shown. Data were analyzed by One-way ANOVA with Tukey’s multiple comparisons test. NS, not significant; * P < 0.05, ** P < 0.01, *** P < 0.001
Article Snippet: The morphology of α-Syn species was confirmed by negative stain transmission electron microscopy. α-Syn oligomers (StressMarq, cat# SPR-484) and
Techniques: Flow Cytometry