sinr4a1 Search Results


sinr4a1  (Kaneka Corp)
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Kaneka Corp sinr4a1
(a) Gel retardation assay showing complete complexation of siRN4A1 with RΔFRGD NPs at 1:40 <t>(siNR4A1/RΔFRGD,</t> w/w). (b) ζ-Potential of the RΔFRGD-siNR4A1 nanocomplex, 1.95 ± 0.18 mV ( n = 3). (c) Transmission electron microscopy image of the RΔFRGD-siNR4A1 nanocomplex ( n = 3).
Sinr4a1, supplied by Kaneka Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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(a) Gel retardation assay showing complete complexation of siRN4A1 with RΔFRGD NPs at 1:40 (siNR4A1/RΔFRGD, w/w). (b) ζ-Potential of the RΔFRGD-siNR4A1 nanocomplex, 1.95 ± 0.18 mV ( n = 3). (c) Transmission electron microscopy image of the RΔFRGD-siNR4A1 nanocomplex ( n = 3).

Journal: ACS Omega

Article Title: Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis

doi: 10.1021/acsomega.2c05292

Figure Lengend Snippet: (a) Gel retardation assay showing complete complexation of siRN4A1 with RΔFRGD NPs at 1:40 (siNR4A1/RΔFRGD, w/w). (b) ζ-Potential of the RΔFRGD-siNR4A1 nanocomplex, 1.95 ± 0.18 mV ( n = 3). (c) Transmission electron microscopy image of the RΔFRGD-siNR4A1 nanocomplex ( n = 3).

Article Snippet: siNR4A1 was provided by Eurogentec (Seraing, Belgium).

Techniques: Electrophoretic Mobility Shift Assay, Transmission Assay, Electron Microscopy

Cytotoxicity of RΔFRGD NPs and the RΔFRGD-siNR4A1 nanocomplex treated with four cell lines and monitored by the MTT assay. Percentage cell viability against WRL 68, Hep G2, Huh7, and HEK 293T cells treated with different concentrations of (a) RΔFRGD NPs and (c) RΔFRGD-siNR4A1 nanocomplex. (b, d) Percentage hemolysis for RΔFRGD NPs and the RΔFRGD-siNR4A1 nanocomplex. (e) IFN-γ response for RΔFRGD at different concentrations and two well-known peptide-based antigens as the positive control, NYESO-1 and MAGE-3, in vitro coculture of T cells with DCs. The data has been presented as mean ± standard deviation.

Journal: ACS Omega

Article Title: Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis

doi: 10.1021/acsomega.2c05292

Figure Lengend Snippet: Cytotoxicity of RΔFRGD NPs and the RΔFRGD-siNR4A1 nanocomplex treated with four cell lines and monitored by the MTT assay. Percentage cell viability against WRL 68, Hep G2, Huh7, and HEK 293T cells treated with different concentrations of (a) RΔFRGD NPs and (c) RΔFRGD-siNR4A1 nanocomplex. (b, d) Percentage hemolysis for RΔFRGD NPs and the RΔFRGD-siNR4A1 nanocomplex. (e) IFN-γ response for RΔFRGD at different concentrations and two well-known peptide-based antigens as the positive control, NYESO-1 and MAGE-3, in vitro coculture of T cells with DCs. The data has been presented as mean ± standard deviation.

Article Snippet: siNR4A1 was provided by Eurogentec (Seraing, Belgium).

Techniques: MTT Assay, Positive Control, In Vitro, Standard Deviation

(a) Confocal microscopy images of healthy and cirrhotic rats intravenously administered with labeled RΔFRGD NPs, showing significant accumulation of the NPs in the liver of cirrhotic rats ( n = 3). (b) NR4A1 mRNA expression in healthy and experimental liver cirrhotic rats ( n = 6). (c) Quantitative real-time PCR ( n = 6) and (d) relative protein expression of NR4A1 in cirrhotic liver treated with the RΔFRGD-siNR4A1 nanocomplex, determined by western blotting. Histopathological images for cirrhotic liver sections stained with (e) hematoxylin and eosin stain (H&E) indicating the presence of enhanced inflammatory cell infiltration in the group treated with the RΔFRGD-siNR4A1 nanocomplex (periceptal nuclei in blue) as compared to the vehicle group. (f) Masson’s trichrome (MT) showing significant aggravation in hepatic fibrosis in the RΔFRGD-siNR4A1-treated group as the red stain has been pulled out by collagen in this group. *BV, blood vessels.

Journal: ACS Omega

Article Title: Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis

doi: 10.1021/acsomega.2c05292

Figure Lengend Snippet: (a) Confocal microscopy images of healthy and cirrhotic rats intravenously administered with labeled RΔFRGD NPs, showing significant accumulation of the NPs in the liver of cirrhotic rats ( n = 3). (b) NR4A1 mRNA expression in healthy and experimental liver cirrhotic rats ( n = 6). (c) Quantitative real-time PCR ( n = 6) and (d) relative protein expression of NR4A1 in cirrhotic liver treated with the RΔFRGD-siNR4A1 nanocomplex, determined by western blotting. Histopathological images for cirrhotic liver sections stained with (e) hematoxylin and eosin stain (H&E) indicating the presence of enhanced inflammatory cell infiltration in the group treated with the RΔFRGD-siNR4A1 nanocomplex (periceptal nuclei in blue) as compared to the vehicle group. (f) Masson’s trichrome (MT) showing significant aggravation in hepatic fibrosis in the RΔFRGD-siNR4A1-treated group as the red stain has been pulled out by collagen in this group. *BV, blood vessels.

Article Snippet: siNR4A1 was provided by Eurogentec (Seraing, Belgium).

Techniques: Confocal Microscopy, Labeling, Expressing, Real-time Polymerase Chain Reaction, Western Blot, Staining, H&E Stain

Relative mRNA expression analysis of inflammatory markers for (a) IL-6, (b) TNF-α, and (c) α-SMA for RΔFRGD-Veh and RΔFRGD-siNR4A1 nanocomplexes.

Journal: ACS Omega

Article Title: Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis

doi: 10.1021/acsomega.2c05292

Figure Lengend Snippet: Relative mRNA expression analysis of inflammatory markers for (a) IL-6, (b) TNF-α, and (c) α-SMA for RΔFRGD-Veh and RΔFRGD-siNR4A1 nanocomplexes.

Article Snippet: siNR4A1 was provided by Eurogentec (Seraing, Belgium).

Techniques: Expressing

Effects of RΔFRGD-veh/siNR4A1 on Hepatic and Systemic Hemodynamic in CCl 4 Experimental Cirrhotic Rats <xref ref-type= a " width="100%" height="100%">

Journal: ACS Omega

Article Title: Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis

doi: 10.1021/acsomega.2c05292

Figure Lengend Snippet: Effects of RΔFRGD-veh/siNR4A1 on Hepatic and Systemic Hemodynamic in CCl 4 Experimental Cirrhotic Rats a

Article Snippet: siNR4A1 was provided by Eurogentec (Seraing, Belgium).

Techniques:

Effects of RΔFRGD-veh/siNR4A1 on Biochemical Parameters in CCl 4 Experimental Cirrhotic Rats <xref ref-type= a " width="100%" height="100%">

Journal: ACS Omega

Article Title: Conformationally Restricted Dipeptide-Based Nanoparticles for Delivery of siRNA in Experimental Liver Cirrhosis

doi: 10.1021/acsomega.2c05292

Figure Lengend Snippet: Effects of RΔFRGD-veh/siNR4A1 on Biochemical Parameters in CCl 4 Experimental Cirrhotic Rats a

Article Snippet: siNR4A1 was provided by Eurogentec (Seraing, Belgium).

Techniques: