single-cell sequencing data Search Results


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Nference Inc single-cell rna sequencing data
Significantly upregulated genes in patients with severe COVID-19 compared with patients with mild COVID-19 and control participants in both a single-cell <t>RNA</t> <t>sequencing</t> study and the current study The pink boxes denote genes that are upregulated in the severe cohort as compared with the mild cohort in both stem-cell RNA sequencing and plasma proteomics analysis. T cell 1, T cell 2, plasma cells, macrophages, epithelial cells, and club cells represent the various clusters of cells described in the single-cell RNA sequencing study. TNF=tumour necrosis factor. PFDN2=prefoldin subunit 2. PSME2=proteasome activator complex subunit 2. BTN3A2=butyrophilin subfamily 3 member A2. CAPG=macrophage-capping protein. FLT1=vascular endothelial growth factor receptor 1. CASP1=caspase-1. DDX58=antiviral innate immune response receptor RIG-I. CCL2=C-C motif chemokine 2. IL1B=antiviral innate immune response receptor RIG-I. HMOX1=heme oxygenase 1. MMP7=matrilysin.
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Significantly upregulated genes in patients with severe COVID-19 compared with patients with mild COVID-19 and control participants in both a single-cell RNA sequencing study and the current study The pink boxes denote genes that are upregulated in the severe cohort as compared with the mild cohort in both stem-cell RNA sequencing and plasma proteomics analysis. T cell 1, T cell 2, plasma cells, macrophages, epithelial cells, and club cells represent the various clusters of cells described in the single-cell RNA sequencing study. TNF=tumour necrosis factor. PFDN2=prefoldin subunit 2. PSME2=proteasome activator complex subunit 2. BTN3A2=butyrophilin subfamily 3 member A2. CAPG=macrophage-capping protein. FLT1=vascular endothelial growth factor receptor 1. CASP1=caspase-1. DDX58=antiviral innate immune response receptor RIG-I. CCL2=C-C motif chemokine 2. IL1B=antiviral innate immune response receptor RIG-I. HMOX1=heme oxygenase 1. MMP7=matrilysin.

Journal: The Lancet. Digital Health

Article Title: Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study

doi: 10.1016/S2589-7500(22)00112-1

Figure Lengend Snippet: Significantly upregulated genes in patients with severe COVID-19 compared with patients with mild COVID-19 and control participants in both a single-cell RNA sequencing study and the current study The pink boxes denote genes that are upregulated in the severe cohort as compared with the mild cohort in both stem-cell RNA sequencing and plasma proteomics analysis. T cell 1, T cell 2, plasma cells, macrophages, epithelial cells, and club cells represent the various clusters of cells described in the single-cell RNA sequencing study. TNF=tumour necrosis factor. PFDN2=prefoldin subunit 2. PSME2=proteasome activator complex subunit 2. BTN3A2=butyrophilin subfamily 3 member A2. CAPG=macrophage-capping protein. FLT1=vascular endothelial growth factor receptor 1. CASP1=caspase-1. DDX58=antiviral innate immune response receptor RIG-I. CCL2=C-C motif chemokine 2. IL1B=antiviral innate immune response receptor RIG-I. HMOX1=heme oxygenase 1. MMP7=matrilysin.

Article Snippet: Publicly available single-cell RNA sequencing data were analysed from three COVID-19 studies using the in-house platform at nference (Cambridge, MA, USA; ).

Techniques: Control, RNA Sequencing, Clinical Proteomics