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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: Extracellular Vesicle Proteins and MicroRNAs Are Linked to Chronic Post-Traumatic Stress Disorder Symptoms in Service Members and Veterans With Mild Traumatic Brain Injury
doi: 10.3389/fphar.2021.745348
Figure Lengend Snippet: EV levels of protein biomarkers. Participants were classified into three groups based on TBI history and severity of PTSD symptoms as measured by the PTSD Checklist for DSM-5 (PCL-5): 1) Control (i.e., -TBI and -PTSD); 2) +mTBI/-PTSD; 3) +mTBI/+PTSD. Group comparisons were performed by using Kruskal-Wallis test followed by Dunn’s test, and Bonferroni method to correct for multiple comparisons. p values refer to pairwise comparisons (A) or to overall group comparisons (B–H) . Biomarker concentrations were represented as median ± IQR. Concentrations were log transformed to improve data visualization in the graphs. Abbreviations: Neurofilament light (NfL), Amyloid beta 42 (AB42), Amyloid beta 40 (AB40), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor -alpha (TNFα), and endothelial growth factor (VEGF).
Article Snippet: EV and plasma levels of NfL (NF-light Simoa Assay, item 103,186, Quanterix, Lexington, MA, United States), Tau, Aβ42, Aβ40 (Neurology 3-Plex A, item 101,995, Quanterix), IL-10, IL-6, TNFα (Cytokine 3-Plex A, item 101,160, Quanterix), and VEGF (
Techniques: Control, Biomarker Discovery, Transformation Assay