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Image Search Results
Journal: bioRxiv
Article Title: Orbitofrontal noradrenaline mediates volatility-dependent adjustment of learning rate
doi: 10.64898/2025.12.11.693701
Figure Lengend Snippet: (A) Schematic representation of viral expression across subjects, showing the extent of AAV8-CaMKII-hM4D(Gi)-mCherry expression within the orbitofrontal cortex (OFC; VO and LO subregions). Each animal is represented as a separate layer (n = 12). (B) Representative fluorescence image illustrating AAV8-CaMKII-hM4D(Gi)-mCherry expression within the OFC (+4.2 mm from Bregma). (C) Mean number of reversals completed per 100 trials under vehicle (VEH) and deschloroclozapine (DCZ, 0.1 mg/kg, i.p.) treatments. (D) Post-reversal adaptation showing the trial-by-trial probability of selecting the high-probability lever following contingency reversals under VEH and DCZ conditions. (E) Proportions of high-reward probability lever-presses during the post-reversal period (left) and during stable phases (right) under VEH and DCZ treatments (***p < 0.001; n.s., not significant). (F) Average number of consecutive (perseverative) errors following reversals under VEH and DCZ conditions (***p < 0.001). (G) Probability of switching levers following different outcome types: rewarded (win), unrewarded (lose), high-probability (high), or low-probability (low) lever presses in the post-reversal phase (*p < 0.05). (H) Conditional probability of switching based on recent action–outcome sequences across the last two trials under VEH and DCZ treatments (*p < 0.05). (I) Learning rates (α) estimated from a standard reinforcement-learning model fitted to behavioral data under VEH and DCZ conditions (**p < 0.01). Data are presented as mean ± SEM.
Article Snippet: The
Techniques: Expressing, Fluorescence
Journal: bioRxiv
Article Title: Orbitofrontal noradrenaline mediates volatility-dependent adjustment of learning rate
doi: 10.64898/2025.12.11.693701
Figure Lengend Snippet: (A) Representative images showing the viral injection site in the orbitofrontal cortex (OFC; left) and retrogradely labeled mCherry-positive neurons in the locus coeruleus (LC; right). (B) Mean number of reversals per 100 trials under vehicle (VEH) and deschloroclozapine (DCZ; 0.1 mg/kg, i.p.) treatment, showing no effect of LC→OFC inhibition on the frequency of contingency reversals (n.s.). (C) Probability of switching levers following rewarded (win), unrewarded (lose), high-probability (high), or low-probability (low) lever presses in the post-reversal phase (p < 0.01). (D) Conditional switching probability following unrewarded outcomes, shown as a function of the total number of rewards obtained on the same lever across the preceding three trials (p < 0.01). Data are presented as mean ± SEM.
Article Snippet: The
Techniques: Injection, Labeling, Inhibition