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li cor odyssey fc imager  (LI-COR)
99
LI-COR li cor odyssey fc imager
Li Cor Odyssey Fc Imager, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/li cor odyssey fc imager/product/LI-COR
Average 99 stars, based on 1 article reviews
li cor odyssey fc imager - by Bioz Stars, 2026-06
99/100 stars
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functional ultrasound device  (ICONEUS)
95
ICONEUS functional ultrasound device
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
Functional Ultrasound Device, supplied by ICONEUS, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/functional ultrasound device/product/ICONEUS
Average 95 stars, based on 1 article reviews
functional ultrasound device - by Bioz Stars, 2026-06
95/100 stars
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olympus slideview vs200 scanner  (Olympus)
99
Olympus olympus slideview vs200 scanner
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
Olympus Slideview Vs200 Scanner, supplied by Olympus, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/olympus slideview vs200 scanner/product/Olympus
Average 99 stars, based on 1 article reviews
olympus slideview vs200 scanner - by Bioz Stars, 2026-06
99/100 stars
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odyssey infrared imaging system  (LI-COR)
99
LI-COR odyssey infrared imaging system
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
Odyssey Infrared Imaging System, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/odyssey infrared imaging system/product/LI-COR
Average 99 stars, based on 1 article reviews
odyssey infrared imaging system - by Bioz Stars, 2026-06
99/100 stars
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c digit scanner  (LI-COR)
99
LI-COR c digit scanner
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
C Digit Scanner, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/c digit scanner/product/LI-COR
Average 99 stars, based on 1 article reviews
c digit scanner - by Bioz Stars, 2026-06
99/100 stars
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odyssey dlx system  (LI-COR)
99
LI-COR odyssey dlx system
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
Odyssey Dlx System, supplied by LI-COR, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/odyssey dlx system/product/LI-COR
Average 99 stars, based on 1 article reviews
odyssey dlx system - by Bioz Stars, 2026-06
99/100 stars
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primehisto xe histology slide scanner  (Carolina Biological)
92
Carolina Biological primehisto xe histology slide scanner
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
Primehisto Xe Histology Slide Scanner, supplied by Carolina Biological, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/primehisto xe histology slide scanner/product/Carolina Biological
Average 92 stars, based on 1 article reviews
primehisto xe histology slide scanner - by Bioz Stars, 2026-06
92/100 stars
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highlight fl4000csm arm  (Coherent Corp)
93
Coherent Corp highlight fl4000csm arm
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
Highlight Fl4000csm Arm, supplied by Coherent Corp, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/highlight fl4000csm arm/product/Coherent Corp
Average 93 stars, based on 1 article reviews
highlight fl4000csm arm - by Bioz Stars, 2026-06
93/100 stars
  Buy from Supplier
500 bp  (MACHEREY NAGEL)
93
MACHEREY NAGEL 500 bp
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
500 Bp, supplied by MACHEREY NAGEL, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/500 bp/product/MACHEREY NAGEL
Average 93 stars, based on 1 article reviews
500 bp - by Bioz Stars, 2026-06
93/100 stars
  Buy from Supplier
256 slice somatom definition flash  (Siemens Healthineers)
86
Siemens Healthineers 256 slice somatom definition flash
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
256 Slice Somatom Definition Flash, supplied by Siemens Healthineers, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/256 slice somatom definition flash/product/Siemens Healthineers
Average 86 stars, based on 1 article reviews
256 slice somatom definition flash - by Bioz Stars, 2026-06
86/100 stars
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64 slice spiral ct scanners  (Philips Healthcare)
86
Philips Healthcare 64 slice spiral ct scanners
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
64 Slice Spiral Ct Scanners, supplied by Philips Healthcare, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/64 slice spiral ct scanners/product/Philips Healthcare
Average 86 stars, based on 1 article reviews
64 slice spiral ct scanners - by Bioz Stars, 2026-06
86/100 stars
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philips ingenia 3t scanner  (Philips Healthcare)
86
Philips Healthcare philips ingenia 3t scanner
A) Representative images of the cerebral microvasculature recorded by functional <t>ultrasound</t> imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.
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A) Representative images of the cerebral microvasculature recorded by functional ultrasound imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.

Journal: bioRxiv

Article Title: Rejuvenation of the Aged Cerebrovascular System via Protein Corona–Guided Fusogenic Liposome Delivery

doi: 10.64898/2026.03.05.709925

Figure Lengend Snippet: A) Representative images of the cerebral microvasculature recorded by functional ultrasound imaging resulting in the presented ultrasound localization microscopy images. Vascular density has been measured in the cortical (CX) and hippocampal (HIPP) areas of the mouse brain. B–C) Quantification of the cortical and hippocampal cerebral vascular density in young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated animals. D–E) Measurement of neurovascular coupling responses in the young, aged, aged + FL-RSV and aged + ApoE-FL-RSV treated mice. Note the significant differences between aged, aged + FL-RSV and aged + ApoE-FL-RSV. Data is shown in mean±SEM. *p<0.05, **p<0.01, ***p<0.001 with ANOVA, N≥8 for all groups. F) Single-cell RNA-seq analysis reveals restoration of endothelial heterogeneity with treatment. Stacked bar plots showing the proportional abundance of vascular cell populations across experimental groups. Aging markedly reduces angiogenic and proliferating endothelial subtypes, whereas FL-RSV and particularly APOE-FL-RSV treatment partially restores endothelial diversity and the presence of regenerative cell states, suggesting improved vascular maintenance capacity. G) Gene ontology enrichment indicates reduced endothelial senescence and improved barrier maintenance after APOE-FL-RSV treatment. Heatmap of endothelial GO term enrichment scores demonstrates that aging increased pathways associated with cellular senescence, endothelial stress, and barrier dysfunction, while APOE-FL-RSV shifted expression toward gene sets linked to blood–brain barrier integrity, lipid transport, and endothelial homeostasis. H-I) Measurement of learning and memory functions of the young, aged, aged + FL-RSV, aged + ApoE-FL-RSV treated animals and aged animals that have RSV per os . Young control and aged BL6 mice were subjected to vehicle, RSV per os , FL-RSV and ApoE-FL-RSV treatments and assessed for their spatial learning and memory using the Radial Arm Water Maze (RAWM). During the learning phase (days 2 to 6) and on probe (P), retrieval (R) and relearn (L) days aged mice displayed higher combined error rates compared to young mice. Treatment with FL-RSV and ApoE-FL-RSV significantly enhanced learning performance in aged mice relative to their untreated counterparts. The combined error rate was computed by adding one error for each incorrect arm entry plus an error for every 15 seconds of inactivity. Data are presented as mean±SEM (N=10–15 per group). Statistical significance indicated by *p<0.05, **p<0.01, ***p<0.001 using Repeated Measure ANOVA, demonstrating the beneficial effects of FL-RSV and ApoE-FL-RSV treatments on enhancing cognitive functions in aged mice, particularly in spatial learning, but less so in tasks requiring cognitive flexibility.

Article Snippet: The ultrasonic probe (IcoPrime-4D MultiArray 15 MHz, ICONEUS, France) of the ICONEUS One functional ultrasound device (ICONEUS, France) was positioned directly above the cranial window and submerged in ultrasound gel (Gel de contact, Drexco Medical, France).

Techniques: Functional Assay, Imaging, Ultrasound Localization Microscopy, Single Cell, RNA Sequencing, Expressing, Control