Journal: Human Brain Mapping

Article Title: Altered processing of communication signals in the subcortical auditory sensory pathway in autism

doi: 10.1002/hbm.25766

Figure Lengend Snippet: Overview of medial geniculate body (MGB) and inferior colliculus (IC) masks used as ROIs. Masks are plotted on a group mean structural image (experiment 1/2; n = 32) (a). (b,c) For the voice identity recognition and the vocal sound experiment, we used masks from the MGB (b, cyan) and IC (c, yellow) provided in an independent atlas on the human subcortical auditory system (Sitek et al., ). (d) For the speech‐in‐noise recognition experiment, participant functionally defined MGB and IC masks were available. These were based on data from the voice identity recognition experiment (green) from individuals ( n = 17) who participated in both experiments (i.e., the speech‐in‐noise recognition and the voice identity recognition experiment). P, posterior; S, superior; A, anterior; I, inferior; L, left; R, right; x , y , z , coordinates in MNI space; MGB, medial geniculate body; IC, inferior colliculus

Article Snippet: The analyses with the ROIs provided in an independent atlas on the human subcortical auditory system (Sitek et al., ) confirmed the higher BOLD responses in the right IC in the control group ( p = .011 FWE corrected, Bonferroni corrected for the four ROIs), but not for the left IC ( p = .177 FWE corrected).

Techniques:

Journal: Human Brain Mapping

Article Title: Altered processing of communication signals in the subcortical auditory sensory pathway in autism

doi: 10.1002/hbm.25766

Figure Lengend Snippet: Functional magnetic resonance imaging (fMRI) results for the right inferior colliculus (IC) in the voice identity recognition experiment (a) and the vocal sound experiment (b). The control group showed enhanced blood oxygenation level‐dependent (BOLD) responses in the right IC when performing the speaker identity task as compared to when performing the speech recognition task (a, controls ) and when listening to vocal sounds as compared to when listening to non‐vocal sounds (b, controls ). There was no such enhanced response for the right IC within the ASD group (a and b, ASD ) and this difference between the groups was significant (a and b, controls > ASD ). Results are presented for the right IC and overlaid onto a group specific average image of normalised T1‐weighted structural images. For ROI analyses in both experiments, we used independent masks provided in an atlas of the human subcortical auditory system (Sitek et al., ). The results are significant at p < .0125 family wise error (FWE) corrected, and Bonferroni corrected for four ROIs (i.e., left and right IC and left and right medial geniculate body [MGB]). For display purposes only, the threshold of p = .05 uncorrected was used. Colour bars represent t ‐values. P, posterior; S, superior; A, anterior; I, inferior; L, left; R, right; x , y , z , coordinates in Montreal Neurological Institute (MNI) space

Article Snippet: The analyses with the ROIs provided in an independent atlas on the human subcortical auditory system (Sitek et al., ) confirmed the higher BOLD responses in the right IC in the control group ( p = .011 FWE corrected, Bonferroni corrected for the four ROIs), but not for the left IC ( p = .177 FWE corrected).

Techniques: Functional Assay, Magnetic Resonance Imaging, Control