ro8191 Search Results


ro8191  (MedChemExpress)
94
MedChemExpress ro8191
Ro8191, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ro8191/product/MedChemExpress
Average 94 stars, based on 1 article reviews
ro8191 - by Bioz Stars, 2026-03
94/100 stars
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ro8191  (TargetMol)
93
TargetMol ro8191
(A) The experimental procedure of the artificial DI mouse. Ovariectomy (OVX) and subcutaneous administration of siliconized medroxyprogesterone acetate (MPA) were performed on D3. A single injection of oil or <t>RO8191</t> was performed on D7. Females were euthanized and dissected on D10. (B) Representative images of the gross uterine morphology. Blastocysts were recovered from oil-treated mice (white arrowheads). Implantation sites (yellow arrowheads on right panel) were visible in DI mice after RO8191 treatment. Scale bars: 1 cm for uterine images and 200 μm for blastocysts. (C, D) Implantation rate (C) and the number of implantation sites (D) in the oil and RO8191-treated DI mice. * indicates significantly different (p < 0.0001). (E) Representative histological image of uterine cross-sections of implantation sites on D10 after RO8191 treatment in DI mice. Right panels are higher magnification of left panels indicated by yellow line. Lower panels indicated abnormal embryo development and decidual reaction. Scale bars: 100 μm. dec: decidua; em: embryo.
Ro8191, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ro8191/product/TargetMol
Average 93 stars, based on 1 article reviews
ro8191 - by Bioz Stars, 2026-03
93/100 stars
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small molecule ro8191  (Chugai)
90
Chugai small molecule ro8191
(A) The experimental procedure of the artificial DI mouse. Ovariectomy (OVX) and subcutaneous administration of siliconized medroxyprogesterone acetate (MPA) were performed on D3. A single injection of oil or <t>RO8191</t> was performed on D7. Females were euthanized and dissected on D10. (B) Representative images of the gross uterine morphology. Blastocysts were recovered from oil-treated mice (white arrowheads). Implantation sites (yellow arrowheads on right panel) were visible in DI mice after RO8191 treatment. Scale bars: 1 cm for uterine images and 200 μm for blastocysts. (C, D) Implantation rate (C) and the number of implantation sites (D) in the oil and RO8191-treated DI mice. * indicates significantly different (p < 0.0001). (E) Representative histological image of uterine cross-sections of implantation sites on D10 after RO8191 treatment in DI mice. Right panels are higher magnification of left panels indicated by yellow line. Lower panels indicated abnormal embryo development and decidual reaction. Scale bars: 100 μm. dec: decidua; em: embryo.
Small Molecule Ro8191, supplied by Chugai, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/small molecule ro8191/product/Chugai
Average 90 stars, based on 1 article reviews
small molecule ro8191 - by Bioz Stars, 2026-03
90/100 stars
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ro8191  (Glaxo Smith)
90
Glaxo Smith ro8191
(A) The experimental procedure of the artificial DI mouse. Ovariectomy (OVX) and subcutaneous administration of siliconized medroxyprogesterone acetate (MPA) were performed on D3. A single injection of oil or <t>RO8191</t> was performed on D7. Females were euthanized and dissected on D10. (B) Representative images of the gross uterine morphology. Blastocysts were recovered from oil-treated mice (white arrowheads). Implantation sites (yellow arrowheads on right panel) were visible in DI mice after RO8191 treatment. Scale bars: 1 cm for uterine images and 200 μm for blastocysts. (C, D) Implantation rate (C) and the number of implantation sites (D) in the oil and RO8191-treated DI mice. * indicates significantly different (p < 0.0001). (E) Representative histological image of uterine cross-sections of implantation sites on D10 after RO8191 treatment in DI mice. Right panels are higher magnification of left panels indicated by yellow line. Lower panels indicated abnormal embryo development and decidual reaction. Scale bars: 100 μm. dec: decidua; em: embryo.
Ro8191, supplied by Glaxo Smith, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ro8191/product/Glaxo Smith
Average 90 stars, based on 1 article reviews
ro8191 - by Bioz Stars, 2026-03
90/100 stars
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ro8191  (ApexBio)
90
ApexBio ro8191
The IFN‐I receptor agonist <t>RO8191</t> attenuates the anti‐inflammatory and cardiac reparative effects of hEPs. A) Cardiac performance measured by echocardiography. All mice received intragastric administration of 10 mg kg −1 RO8191 or vehicle control (corn oil) 30 min before MI surgery. n = 6, 8, 6, and 8 in the MI, MI + hEPs, MI + RO8191, and MI + hEPs + RO8191 groups. ** p < 0.01, *** p < 0.001, and n.s.(no significant difference) versus the MI group. # p < 0.05, ## p < 0.01, and n.s. as indicated. B) Representative images and quantitative analysis of scar sizes stained with Masson's trichrome at day 28 post‐MI. n = 6 to 7. Scale bar: 1 mm. C,D) Representative images and quantitative data of immunofluorescent staining for CD31 + endothelial cells (C, n = 5 to 6) and LYVE1 + lymphatic vessels (D, n = 4 to 7) in the border zones at day 28 post‐MI. Scale bar: 50 µm. E) Representative images and quantitative data of immunofluorescent staining for TUNEL + CMs in the border zones at day 3 post‐MI. n = 4 to 5. Scale bar: 20 µm. F) Representative images and quantitative data of immunofluorescent staining for CD68 + cells and CD68 + CD206 + macrophages in the border zones at day 3 post‐MI. n = 5 to 6. Scale bar: 50 µm. Data are means ± S.E.M. Two‐way ANOVA followed by Bonferroni's multiple analysis in A to F. * p < 0.05, ** p < 0.01, and *** p < 0.001. n.s.: no significant difference.
Ro8191, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ro8191/product/ApexBio
Average 90 stars, based on 1 article reviews
ro8191 - by Bioz Stars, 2026-03
90/100 stars
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ro8191  (Cayman Chemical)
90
Cayman Chemical ro8191
The IFN‐I receptor agonist <t>RO8191</t> attenuates the anti‐inflammatory and cardiac reparative effects of hEPs. A) Cardiac performance measured by echocardiography. All mice received intragastric administration of 10 mg kg −1 RO8191 or vehicle control (corn oil) 30 min before MI surgery. n = 6, 8, 6, and 8 in the MI, MI + hEPs, MI + RO8191, and MI + hEPs + RO8191 groups. ** p < 0.01, *** p < 0.001, and n.s.(no significant difference) versus the MI group. # p < 0.05, ## p < 0.01, and n.s. as indicated. B) Representative images and quantitative analysis of scar sizes stained with Masson's trichrome at day 28 post‐MI. n = 6 to 7. Scale bar: 1 mm. C,D) Representative images and quantitative data of immunofluorescent staining for CD31 + endothelial cells (C, n = 5 to 6) and LYVE1 + lymphatic vessels (D, n = 4 to 7) in the border zones at day 28 post‐MI. Scale bar: 50 µm. E) Representative images and quantitative data of immunofluorescent staining for TUNEL + CMs in the border zones at day 3 post‐MI. n = 4 to 5. Scale bar: 20 µm. F) Representative images and quantitative data of immunofluorescent staining for CD68 + cells and CD68 + CD206 + macrophages in the border zones at day 3 post‐MI. n = 5 to 6. Scale bar: 50 µm. Data are means ± S.E.M. Two‐way ANOVA followed by Bonferroni's multiple analysis in A to F. * p < 0.05, ** p < 0.01, and *** p < 0.001. n.s.: no significant difference.
Ro8191, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ro8191/product/Cayman Chemical
Average 90 stars, based on 1 article reviews
ro8191 - by Bioz Stars, 2026-03
90/100 stars
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Image Search Results


(A) The experimental procedure of the artificial DI mouse. Ovariectomy (OVX) and subcutaneous administration of siliconized medroxyprogesterone acetate (MPA) were performed on D3. A single injection of oil or RO8191 was performed on D7. Females were euthanized and dissected on D10. (B) Representative images of the gross uterine morphology. Blastocysts were recovered from oil-treated mice (white arrowheads). Implantation sites (yellow arrowheads on right panel) were visible in DI mice after RO8191 treatment. Scale bars: 1 cm for uterine images and 200 μm for blastocysts. (C, D) Implantation rate (C) and the number of implantation sites (D) in the oil and RO8191-treated DI mice. * indicates significantly different (p < 0.0001). (E) Representative histological image of uterine cross-sections of implantation sites on D10 after RO8191 treatment in DI mice. Right panels are higher magnification of left panels indicated by yellow line. Lower panels indicated abnormal embryo development and decidual reaction. Scale bars: 100 μm. dec: decidua; em: embryo.

Journal: bioRxiv

Article Title: RO8191, a new compound for initiating embryo implantation in mice

doi: 10.1101/2024.09.30.615945

Figure Lengend Snippet: (A) The experimental procedure of the artificial DI mouse. Ovariectomy (OVX) and subcutaneous administration of siliconized medroxyprogesterone acetate (MPA) were performed on D3. A single injection of oil or RO8191 was performed on D7. Females were euthanized and dissected on D10. (B) Representative images of the gross uterine morphology. Blastocysts were recovered from oil-treated mice (white arrowheads). Implantation sites (yellow arrowheads on right panel) were visible in DI mice after RO8191 treatment. Scale bars: 1 cm for uterine images and 200 μm for blastocysts. (C, D) Implantation rate (C) and the number of implantation sites (D) in the oil and RO8191-treated DI mice. * indicates significantly different (p < 0.0001). (E) Representative histological image of uterine cross-sections of implantation sites on D10 after RO8191 treatment in DI mice. Right panels are higher magnification of left panels indicated by yellow line. Lower panels indicated abnormal embryo development and decidual reaction. Scale bars: 100 μm. dec: decidua; em: embryo.

Article Snippet: The RO8191 (T22142, TargetMol) was dissolved in sesame oil (196-15385, FujiFilm Wako Pure Chemicals), and a single intraperitoneal (i.p.) injection of RO8191 (400 μg/head; dissolved in sesame oil) or sesame oil was performed at 1300 h on D7.

Techniques: Injection

(A) The experimental procedure of the genetically modified mice. For control, a single oil injection was performed on D4. For cKOs, a single injection of oil or RO8191 was performed on D4. Females were euthanized and dissected on D7. (B-D) Uterine morphology of cKOs mice after the injection of oil or RO8191. The white arrowheads indicate the presumptive implantation site. Scale bars: 1 cm. (E) The implantation rate in cKOs mice after oil or RO8191 administration. (F) The number of implantation sites in cKOs mice after the injection of oil or RO8191. (G) The size of implantation sites in cKOs mice after oil or RO8191 administration. * indicates significantly different (p < 0.05).

Journal: bioRxiv

Article Title: RO8191, a new compound for initiating embryo implantation in mice

doi: 10.1101/2024.09.30.615945

Figure Lengend Snippet: (A) The experimental procedure of the genetically modified mice. For control, a single oil injection was performed on D4. For cKOs, a single injection of oil or RO8191 was performed on D4. Females were euthanized and dissected on D7. (B-D) Uterine morphology of cKOs mice after the injection of oil or RO8191. The white arrowheads indicate the presumptive implantation site. Scale bars: 1 cm. (E) The implantation rate in cKOs mice after oil or RO8191 administration. (F) The number of implantation sites in cKOs mice after the injection of oil or RO8191. (G) The size of implantation sites in cKOs mice after oil or RO8191 administration. * indicates significantly different (p < 0.05).

Article Snippet: The RO8191 (T22142, TargetMol) was dissolved in sesame oil (196-15385, FujiFilm Wako Pure Chemicals), and a single intraperitoneal (i.p.) injection of RO8191 (400 μg/head; dissolved in sesame oil) or sesame oil was performed at 1300 h on D7.

Techniques: Genetically Modified, Control, Injection

(A, B) Control ( Lifr f/f ) uterus after sesame oil treatment. (C, D) Stat3 cKO, (E, F) Gp130 cKO, and (G, H) Lifr cKO uterus after RO8191 treatment. Higher magnification in yellow frames inserted in D and F. Scale bar, 100 µm. dec: decidua; em: embryo; bv: blood vessels; le: luminal epithelium; li: leukocyte infiltration.

Journal: bioRxiv

Article Title: RO8191, a new compound for initiating embryo implantation in mice

doi: 10.1101/2024.09.30.615945

Figure Lengend Snippet: (A, B) Control ( Lifr f/f ) uterus after sesame oil treatment. (C, D) Stat3 cKO, (E, F) Gp130 cKO, and (G, H) Lifr cKO uterus after RO8191 treatment. Higher magnification in yellow frames inserted in D and F. Scale bar, 100 µm. dec: decidua; em: embryo; bv: blood vessels; le: luminal epithelium; li: leukocyte infiltration.

Article Snippet: The RO8191 (T22142, TargetMol) was dissolved in sesame oil (196-15385, FujiFilm Wako Pure Chemicals), and a single intraperitoneal (i.p.) injection of RO8191 (400 μg/head; dissolved in sesame oil) or sesame oil was performed at 1300 h on D7.

Techniques: Control

The IFN‐I receptor agonist RO8191 attenuates the anti‐inflammatory and cardiac reparative effects of hEPs. A) Cardiac performance measured by echocardiography. All mice received intragastric administration of 10 mg kg −1 RO8191 or vehicle control (corn oil) 30 min before MI surgery. n = 6, 8, 6, and 8 in the MI, MI + hEPs, MI + RO8191, and MI + hEPs + RO8191 groups. ** p < 0.01, *** p < 0.001, and n.s.(no significant difference) versus the MI group. # p < 0.05, ## p < 0.01, and n.s. as indicated. B) Representative images and quantitative analysis of scar sizes stained with Masson's trichrome at day 28 post‐MI. n = 6 to 7. Scale bar: 1 mm. C,D) Representative images and quantitative data of immunofluorescent staining for CD31 + endothelial cells (C, n = 5 to 6) and LYVE1 + lymphatic vessels (D, n = 4 to 7) in the border zones at day 28 post‐MI. Scale bar: 50 µm. E) Representative images and quantitative data of immunofluorescent staining for TUNEL + CMs in the border zones at day 3 post‐MI. n = 4 to 5. Scale bar: 20 µm. F) Representative images and quantitative data of immunofluorescent staining for CD68 + cells and CD68 + CD206 + macrophages in the border zones at day 3 post‐MI. n = 5 to 6. Scale bar: 50 µm. Data are means ± S.E.M. Two‐way ANOVA followed by Bonferroni's multiple analysis in A to F. * p < 0.05, ** p < 0.01, and *** p < 0.001. n.s.: no significant difference.

Journal: Advanced Science

Article Title: hESC‐Derived Epicardial Cells Promote Repair of Infarcted Hearts in Mouse and Swine

doi: 10.1002/advs.202300470

Figure Lengend Snippet: The IFN‐I receptor agonist RO8191 attenuates the anti‐inflammatory and cardiac reparative effects of hEPs. A) Cardiac performance measured by echocardiography. All mice received intragastric administration of 10 mg kg −1 RO8191 or vehicle control (corn oil) 30 min before MI surgery. n = 6, 8, 6, and 8 in the MI, MI + hEPs, MI + RO8191, and MI + hEPs + RO8191 groups. ** p < 0.01, *** p < 0.001, and n.s.(no significant difference) versus the MI group. # p < 0.05, ## p < 0.01, and n.s. as indicated. B) Representative images and quantitative analysis of scar sizes stained with Masson's trichrome at day 28 post‐MI. n = 6 to 7. Scale bar: 1 mm. C,D) Representative images and quantitative data of immunofluorescent staining for CD31 + endothelial cells (C, n = 5 to 6) and LYVE1 + lymphatic vessels (D, n = 4 to 7) in the border zones at day 28 post‐MI. Scale bar: 50 µm. E) Representative images and quantitative data of immunofluorescent staining for TUNEL + CMs in the border zones at day 3 post‐MI. n = 4 to 5. Scale bar: 20 µm. F) Representative images and quantitative data of immunofluorescent staining for CD68 + cells and CD68 + CD206 + macrophages in the border zones at day 3 post‐MI. n = 5 to 6. Scale bar: 50 µm. Data are means ± S.E.M. Two‐way ANOVA followed by Bonferroni's multiple analysis in A to F. * p < 0.05, ** p < 0.01, and *** p < 0.001. n.s.: no significant difference.

Article Snippet: RO8191 (APExBIO) was diluted with corn oil and intragastrically administrated at 10 mg kg −1 within 30 min before MI injury.

Techniques: Control, Staining, TUNEL Assay