rhil-21 Search Results


rhil-21  (ImmunoTools)
90
ImmunoTools rhil-21
Rhil 21, supplied by ImmunoTools, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/rhil+21/pmc04060544-94-9-10
Average 90 stars, based on 1 article reviews
rhil-21 - by Bioz Stars, 2026-11
90/100 stars
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rhil21  (Pfizer Inc)
90
Pfizer Inc rhil21
Whole human blood response to ex vivo stimulation with 10 ng/mL <t>rhIL21</t> for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).
Rhil21, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/rhil21/pmc02892437-130-6-16
Average 90 stars, based on 1 article reviews
rhil21 - by Bioz Stars, 2026-11
90/100 stars
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rhil-21  (Becton Dickinson)
90
Becton Dickinson rhil-21
Whole human blood response to ex vivo stimulation with 10 ng/mL <t>rhIL21</t> for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).
Rhil 21, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/rhil+21/pmc03836837-76-13-14
Average 90 stars, based on 1 article reviews
rhil-21 - by Bioz Stars, 2026-11
90/100 stars
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rhil-21 denenicokin  (Novo Nordisk)
90
Novo Nordisk rhil-21 denenicokin
Whole human blood response to ex vivo stimulation with 10 ng/mL <t>rhIL21</t> for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).
Rhil 21 Denenicokin, supplied by Novo Nordisk, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/rhil+21+denenicokin/pmc03733464-243-13-15
Average 90 stars, based on 1 article reviews
rhil-21 denenicokin - by Bioz Stars, 2026-11
90/100 stars
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rhil-21  (Biomol GmbH)
90
Biomol GmbH rhil-21
Whole human blood response to ex vivo stimulation with 10 ng/mL <t>rhIL21</t> for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).
Rhil 21, supplied by Biomol GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/rhil+21/pm26376181-41-31-32
Average 90 stars, based on 1 article reviews
rhil-21 - by Bioz Stars, 2026-11
90/100 stars
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il21, human  (Gold Biotechnology Inc)
94
Gold Biotechnology Inc il21, human
Whole human blood response to ex vivo stimulation with 10 ng/mL <t>rhIL21</t> for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).
Il21, Human, supplied by Gold Biotechnology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/IL21%2C+Human/custom%401110-21%4010%2E1101%2F2021%2E11%2E04%2E467302
Average 94 stars, based on 1 article reviews
il21, human - by Bioz Stars, 2026-11
94/100 stars
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rhil-21  (Shenandoah Biotechnology)
90
Shenandoah Biotechnology rhil-21
Whole human blood response to ex vivo stimulation with 10 ng/mL <t>rhIL21</t> for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).
Rhil 21, supplied by Shenandoah Biotechnology, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/rhil+21/pm23641014-34-114-115
Average 90 stars, based on 1 article reviews
rhil-21 - by Bioz Stars, 2026-11
90/100 stars
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rhil-21  (Novoprotein)
90
Novoprotein rhil-21
Whole human blood response to ex vivo stimulation with 10 ng/mL <t>rhIL21</t> for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).
Rhil 21, supplied by Novoprotein, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rhil-21/rhil+21/pm37392990-59-11-14
Average 90 stars, based on 1 article reviews
rhil-21 - by Bioz Stars, 2026-11
90/100 stars
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Image Search Results


Whole human blood response to ex vivo stimulation with 10 ng/mL rhIL21 for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).

Journal: Journal of Translational Medicine

Article Title: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

doi: 10.1186/1479-5876-8-51

Figure Lengend Snippet: Whole human blood response to ex vivo stimulation with 10 ng/mL rhIL21 for 2 hours . Data shown are for the 6 genes (of 19 tested) with the most consistent response among the 9 individual donors, and are identified as 6 preferred biomarkers of rhIL21 activity in whole human blood. These 6 genes were also identified as the best indicators of IL21 response in a series of pilot studies conducted with blood from a different group of donors (data not shown).

Article Snippet: All treatments were run in duplicate. rhIL21 (produced from Chinese hamster ovary cells at Wyeth, now Pfizer) was added in volumes ranging from 3 μL to 10 μL to achieve the indicated concentration.

Techniques: Ex Vivo, Activity Assay

Determination of optimal time point for rhIL21-response for the 6 genes identified as preferred biomarkers . This time point experiment was done using 5 of the donors shown in Figure 2. Earlier pilot studies had suggested that stimulation for 30 minutes was significantly sub-optimal. There was no significant difference in response between all doses tested (30, 10, and 3 ng/mL). The lowest dose of rhIL21 that elicits a response has therefore not been determined.

Journal: Journal of Translational Medicine

Article Title: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

doi: 10.1186/1479-5876-8-51

Figure Lengend Snippet: Determination of optimal time point for rhIL21-response for the 6 genes identified as preferred biomarkers . This time point experiment was done using 5 of the donors shown in Figure 2. Earlier pilot studies had suggested that stimulation for 30 minutes was significantly sub-optimal. There was no significant difference in response between all doses tested (30, 10, and 3 ng/mL). The lowest dose of rhIL21 that elicits a response has therefore not been determined.

Article Snippet: All treatments were run in duplicate. rhIL21 (produced from Chinese hamster ovary cells at Wyeth, now Pfizer) was added in volumes ranging from 3 μL to 10 μL to achieve the indicated concentration.

Techniques:

Average percent inhibition of the expression level of 6 IL21-responsive genes . Percent inhibition values were calculated based on RQ (relative quantification) values of untreated control and rhIL21-treated samples for each of the 4 donors, and subsequently the mean and standard deviation were determined for each gene shown. A: Percent inhibition in presence of Ab-01. B: Percent inhibition in presence of control IgG 1 TM. Data for the 0.1 μg/mL , 0.3 μg/mL and 1 μg/mL concentrations were generated using 4 donors. Data for the higher and the lower concentrations were generated using 2 donors.

Journal: Journal of Translational Medicine

Article Title: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

doi: 10.1186/1479-5876-8-51

Figure Lengend Snippet: Average percent inhibition of the expression level of 6 IL21-responsive genes . Percent inhibition values were calculated based on RQ (relative quantification) values of untreated control and rhIL21-treated samples for each of the 4 donors, and subsequently the mean and standard deviation were determined for each gene shown. A: Percent inhibition in presence of Ab-01. B: Percent inhibition in presence of control IgG 1 TM. Data for the 0.1 μg/mL , 0.3 μg/mL and 1 μg/mL concentrations were generated using 4 donors. Data for the higher and the lower concentrations were generated using 2 donors.

Article Snippet: All treatments were run in duplicate. rhIL21 (produced from Chinese hamster ovary cells at Wyeth, now Pfizer) was added in volumes ranging from 3 μL to 10 μL to achieve the indicated concentration.

Techniques: Inhibition, Expressing, Quantitative Proteomics, Control, Standard Deviation, Generated

rhIL21-responsive genes in whole cynomolgus monkey blood

Journal: Journal of Translational Medicine

Article Title: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

doi: 10.1186/1479-5876-8-51

Figure Lengend Snippet: rhIL21-responsive genes in whole cynomolgus monkey blood

Article Snippet: All treatments were run in duplicate. rhIL21 (produced from Chinese hamster ovary cells at Wyeth, now Pfizer) was added in volumes ranging from 3 μL to 10 μL to achieve the indicated concentration.

Techniques:

Inhibition by Ab-01 of ex vivo rhIL21-dependent IL2RA expression

Journal: Journal of Translational Medicine

Article Title: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

doi: 10.1186/1479-5876-8-51

Figure Lengend Snippet: Inhibition by Ab-01 of ex vivo rhIL21-dependent IL2RA expression

Article Snippet: All treatments were run in duplicate. rhIL21 (produced from Chinese hamster ovary cells at Wyeth, now Pfizer) was added in volumes ranging from 3 μL to 10 μL to achieve the indicated concentration.

Techniques: Inhibition, Ex Vivo, Control

rhIL21 induced IL2RA expression in whole blood from cynomolgus monkeys dosed with Ab-01

Journal: Journal of Translational Medicine

Article Title: Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood

doi: 10.1186/1479-5876-8-51

Figure Lengend Snippet: rhIL21 induced IL2RA expression in whole blood from cynomolgus monkeys dosed with Ab-01

Article Snippet: All treatments were run in duplicate. rhIL21 (produced from Chinese hamster ovary cells at Wyeth, now Pfizer) was added in volumes ranging from 3 μL to 10 μL to achieve the indicated concentration.

Techniques: Expressing, Control